Jonah Lehrer wrote about the (surprising?) power of publication bias.
http://m.newyorker.com/reporting/2010/12/13/101213fa_fact_lehrer?currentPage=all
Cosma Shalizi (I think) said something, or pointed to something, about the null model of science - what science would look like if there were no actual effects, just statistical anomalies that look good at first. I can't find the reference, though.
I wish I could vote this up several times because of, well, confirmation bias. It's seemed to me that evolutionary psych makes a lot of stew from very little meat, and it looks as though there's even less meat than I thought-- the article says that there's much less evidence of a female preference for male symmetry than was previously believed.
Meanwhile, I wonder if some of the fading of results isn't just publication bias, it's that biological details change faster than we realize. Drugs that work for schizophrenia might stop working as well because people are eating different additives or somesuch.
A simulation hypothesis is fun, of course-- we're being toyed with and/or the program is slightly unstable.
I totally predicted that one. Hmph. Is there a discussion post somewhere for people to post predictions? Ideally it'd be near the top of Top, if people voted it up enough. I like the idea of prediction markets but they seem cumbersome and many sorts of predictions need to be made super precise before you can bet on them, even if they wouldn't have to be that precise to be socially acknowledged as sticking their necks out.