A recent entry from the West Hunters blog (written by Gregory Cochran and Henry Harpending with whom most LWers are probably already familiar with) caught my eye:
People who grow up in a small town, or an old and stable neighborhood, often know their neighbors. More than than that, they know pretty much everything that’s happened for the past couple of generations, whether they want to or not. For many Americans, probably most, this isn’t the case. Mobility breeds anonymity. Suburban kids haven’t necessarily been hanging out with the same peers since kindergarten, and even if they have, they probably don’t much about their friends’ sibs and parents.
If you do have that thick local knowledge, significant trait heritability is fairly obvious. You notice that the valedictorians cluster in a few families, and you also know that those families don’t need to put their kids under high pressure to get those results. They’re just smart. Some are smart but too rebellious to play the game – and that runs in families too. For that matter, you know that those family similarities, although real and noticeable, are far from absolute. You see a lot of variation within a family.
If you don’t have it, it’s easier to believe that cognitive or personality traits are generated by environmental influences – how your family toilet trained you, whether they sent you to a prep school, etc. Easier to believe, but false.
So it isn’t all that difficult to teach quantitative genetics to someone with that background. They already know it, more or less. Possession of this kind of knowledge must have been the norm in the human past. I’m sure that Bushmen have it.
The loss of this knowledge must have significant consequences, not just susceptibility to nurturist dogma. In the typical ancestral situation, you knew a lot about the relatives of all potential mates. Today, you might meet someone in college and know nothing about her family history. In particular, you might not be aware that schizophrenia runs in her family. You can’t weigh what you don’t know. In modern circumstances, I suspect that the reproductive success of people with a fair-sized dose of alleles that predispose to schiz has gone up – with the net consequence that selection is less effective at eliminating such alleles. The modern welfare state has probably had more impact, though. In the days of old, kids were likely to die if a parent flaked out. Today that does not happen.
Seems quite coherent. It meshes well with findings that the more children parents have the less they subscribe to nurture, since they finally, possibly for the first time ever, get some hands on experience with the nurture (nurture as in stuff like upbringing not nurture as in lead paint) versus. nature issue. Note that today urban, educated, highly intelligent people are less likley to have children than possibly ever, how is this likley to effect intellectual fashions?
Perhaps somewhat related to this is also the transition in the past 150 years (the time frame depending on where exactly you live) from agricultural communities, that often raised livestock to urban living. What exactly "variation" and "heredity" might mean in a intuitive way thus comes another source short with no clear replacement.
Yes, hemophilia is an example like Huntington's where there's a family of alleles. And of course, in that case, the allele is extremely lethal, killing a large fraction of males, and killing any female that is homozygous. So the allele has to stay really rare.
In general though for most proteins it is surprisingly difficult to break them. Most mutations will actually be neutral. They will be neutral either because the mutated codon actually codes for the same allele, or codes for a chemically similar allele, or because it is a section of the protein which provides something like structural support, if it mighta ctually have a phenotypical effect that just doesn't matter much either way . Many other mutations might have a negative effect but it won't be the same negative effect or it will be a negligible negative effect.. Moreover, some of the negative effects from mutated proteins aren't because the protein itself is now broken at what it normally does but because the protein now in addition to what it is supposed to do gums something else up or isn't as easily broken down or something like that. Those sorts of things also require specific mutations to occur. So in general, it is very rare for a mutation to get repeated.