We talk about a wide variety of stuff on LW, but we don't spend much time trying to identify the very highest-utility stuff to discuss and promoting additional discussion of it. This thread is a stab at that. Since it's just comments, you can feel more comfortable bringing up ideas that might be wrong or unoriginal (but nevertheless have relatively high expected value, since existential risks are such an important topic).
Is anyone systematically working on the other side of the pancake: existential opportunities?
People are working on particular opportunities, but I haven't heard of people doing the depth first search for opportunities.
(not sure this is the right answer) Potentially FHI prize competition could be seen as an attempt to pursue that end? ( http://www.fhi.ox.ac.uk/prize , it's closed now)