There is a theory of "the path of least resistance" that implies the one should go with the flow. With that in mind, how do you continue to nurture the growth resulting from challenges? Does the rationale of the path of least resistance conflict with the challenges of life that are required for change?
Oh. That's a different metaphor, for advice on an unrelated topic. "path of least resistance" is about making choices and behaviors that are easy, rather than those which lead to the best longer-term outcomes (or are virtuous, if you're more deontologist than consequentialist). "life route" (I think) is just about noticing that they ARE choices, and observing/enjoying the ride, wherever it leads.
Or maybe they're the same metaphor, and "the path" is the recommendation to avoid the easy path and take the virtuous one. I don't hang out with people who use the term enough to really understand the meaning without much more context.