All of BDay's Comments + Replies

BDay20

Not sure why you're getting downvoted. It's ugly but honest. We emotionally associate to countries as if they're people. But they're not. They're made of people. 

BDay20

Not an explanation, but type 2 diabetes is an example of a system failing(/adapting) in one direction and then not being reversible. 

BDay50

Some additional information on this: 

  • PUFA as a proportion of body fat rose from ~10% in 1950 to ~20% in 2010. At least one hunter gatherer population has PUFA levels of 4%. We introduced high PUFA oils into our diets in the early 1900's. 
  • Human body temperature has dropped 0.6C/1.0F over the last 150-200 years. It is not believed to be measurement error. Measurement of a hunter-gatherer tribe showed decreasing body temperatures over time as they became more connected with civilization. It has been theorized the increased intake/body proportion of
... (read more)
BDay10

I should have just stated explicitly I don't think you can achieve hyperpalatability with those as inputs, which is what I'm assuming. 

I agree exaggerated blandness would be a better test, but then doesn't generalise to something you could actually follow for the rest of your life. 

1tailcalled
I would be wary about making too big assumptions about what cannot be achieved when optimization pressure is applied. But maybe. I wouldn't predict past blandness to be something that one could actually follow for the rest of one's life. Though I am not familiar enough with the quality of the foods back then, so I don't know.
BDay10

Very interesting anecdote. This is exactly the sort of change I would expect to have some immediate and noticable effect. Oil might be the culprit but probably not. One reason to do it for 100% of food is just to get rid of the confounders. 

BDay10

I worry that overtly bland is too hard to follow and French is so generous you can still make extremely palatable food.

BDay20

If you hate the diet it's not for the long term, just 3 months. And quitting's fine. It's also not meant to be necessarily bland, just not hyperpalatable 'cafeteria' food. It's meant to be as close to an approximation of what a hunter gatherer tribe would be eating, except in this case you have much more variety with respect to what's available to you in each category. Have you tried fried cinammon pineapple?

Yours is the dream situation and I agree best for happiness. But I think a tighter approach for research is justifiable to get a clearer understanding... (read more)

1Nicole Dieker
I eat honey every day, probably a tablespoon's worth on my morning oatmeal. We don't avoid sugar but we don't go out of our way to add it. None of the food we ate today had sugar in it, for example.  Breakfast: steel-cut oats, fruit, nuts, honey, butter, egg, milk, coffee Lunch: Rice, homemade mango slaw, homemade guacamole, smoked sausage (we didn't make that, but it has no sugar, no HFCS, no nitrates/nitrites, no MSG), grapes, cheese Dinner: Rice, homemade naan, homemade dal, vegetables cooked in butter and various Indian-influenced spices, red wine Dessert: 100% dark chocolate square (Ghirardelli), segmented orange
BDay20

Well the point isn't meant to be that the food is inherently unsatisfying. The point is meant to be that the food is stuff that is within the normal range of palatability we are adapted for. 

There's reasonable justification for adding rice and traditional bread too given their long history of consumption before obesity was common. 

If you can make nice tasting food from that, that's a good thing. If you can achieve genuine 'cafeteria food' hyperpalatability I'll be seriously impressed. It seems like it would be very hard to do without a fat like butter/oil or a sweetener like table sugar/honey. 

4Vaniver
IMO you either want to go the 'French women' approach as described in another comment, or you want to select a food that is 'bland'. The specific property I mean is a psychological reaction, and so it's going to fire for different foods for different people, but basically: when you're starting a meal you want to eat the food, and then when you've eaten enough of the food, you look at more on your plate and go "I'm not finishing that." [This is different from the "I'm too full" reaction; there have been many times that I have put MealSquares back in the fridge when I would have eaten more bread.] One thing that I've tried, but not for long enough to get shareable data, is having the 'second half' of my day's calories be bland food. (That is, cook / order 1000 calories of tasty food, and then eat as many MealSquares as I want afterwards.) This is less convenient than a "cheat day" style of diet, but my guess is it's more psychologically easy.
2tailcalled
I mean it's fair enough that the restrictions needn't be too high. But still, the restriction should be on palatability itself, not on the inputs to the food that may sometimes contribute to palatability (unless you have a highly precise set of restrictions to the inputs that are sufficient to match the tradition). Extra fats and sweeteners do help a lot with palatability. But to some extent, fat could be extracted from other means; to some extent, palatability could be improved by changing proportions; etc.. Even things like careful optimization through large-scale experimentation will help with palatability, and so should probably be avoided. Let's say people didn't used to be obese in the 50's. Ok, what did people eat back then? How palatable was it, on average? That seems like what one should aim for. Maybe one can contact a food historian or something to figure out more? ---------------------------------------- I should also add: assuming some sort of monotonicity, it may be helpful for the statistics to exaggerate the unpalatability compared to the past, because it increases the expected effect if palatability matters, and so makes it easier to detect. But obviously it comes with the downside that it's not as clear whether it really matches what you'd eat on a medium-palatability diet.
Viliam100

As a Christmas present I got a rice cooker, with the recommendation to use for things other than rice.

For those unfamiliar with this kind of device, it basically heats the water until it evaporates, and then it automatically turns itself off, so the food is actually cooked in the vapor rather than in hot water. (With the rice it provides instructions on how much water for how much rice to get it right. With other food, you are on your own, but in my experience 1 dl water was enough for everything.)

Turns out, vegetables cooked this way are super delicious. ... (read more)

BDay60

In defense of bread, butter and milk: 

A traditional bread like sourdough has a glycemic index of 54 and 12g protein per 100g. While I love the taste, I wouldn't classify it as hyperpalatable. It only has 4 ingredients: flour, salt, water and bacteria. I would classify it in the middle between hyperpalatable and bland. 

I don't think plain butter or milk are hyperpalatble either. Only when used in certain ways in recipes do they result in hyperpalatable foods. Personally, I don't like plain milk and couldn't eat butter on its own. 

Nutritionally, I would also dispute that these are unhealthy if this is being implied. To my knowlege, saturated fats are no longer thought to be bad for health.

BDay40

This might just be nitpicking. I disagree with or perhaps don't understand the "set point" usage that is common here. I see it more as a balance of inputs to the brain from the mouth and stomach/other satiety sensors. 

Plain boiled potatoes have a taste pleasure score of 3, and thus a satiation score of 3 from the stomach is required to stop you eating more of them. 

Chocolate cake has a taste pleasure score of 8, and so a satiation score of 8 from the stomach is required to stop you eating more. 

As you require a stronger satiation score to ov... (read more)

BDay10

Thanks for your comments.

  1. Good points.
  2. I disagree, but I think your view is more supported by others than mine. I think experts learn, but very few voters do. 
  3. I think this is also perverse and causal. Universities have very one-sided incentives with regard to who it makes sense for them to support politically. 
  4. Rent control prevents the market from working and building more stock, which harms everyone else. 
  5. I agree. Our right wing politics is mostly a grift. 
  6. Agree. Incentives are very different for rich and poor, and poor might be motivated by dependency whereas rich are not. 
BDay10

The right can definitely exploit jingoism for support to some degree. But I don't think the economic case is symmetrical. What is an actual lever, as powerful as welfare, which the Right could pull (even in other eras) to increase its support? 

Re Trump, what matters is the overall incentive. If it's a 55/45 trend, lots of people are going to buck the trend but it still exists. Trump couldn't run on a platform of welfare and government spending cutbacks, to the policies are also winning independent of the politicians. 

BDay10

Do you mean progress in the good sense or the progressive political sense? I am arguing this is so in the political sense, but not neccessarily the good sense. So of course trade liberalisation would continue, because it is politically progressive, but not actual progress for many people in Western countries. 

If rent control schemes are still taken seriously anywhere, is that not still a massive defeat? This theory would predict that a massive amount of energy could be poured into moving housing policy in the right direction, but only make a small amo... (read more)

BDay20

This is very interesting. You certainly can't argue with the availability of hyperpalatable food in these countries. To the extent they are less available in stores, that would be the result of people wanting them less. 

Perhaps the consumption is lower because of their culture (mimesis effects). People eat what those around them eat, and the traditional diet is culturally sticky enough in Japan and South Korea that, in spite of the availability of hyperpalatable foods, people still follow it for the majority of meals. However, this explanation require... (read more)

BDay110

The study I would like to see is giving obese people unlimited access to only natural foods for 3 months. They could add salt and spices, but no oil and definitely no sugar. The diet would be lean(ish) meats, fruits, vegetables and legumes (unsure if allowing nuts is a good idea as they're extremely calorie dense, but technically they should be allowed under this definition). 

I would be surprised if this didn't work. Under this model I view hyperpalatble foods as equivalent to an addictive drug for obese people. Just as if you have a poor phenotype fo... (read more)

-2deepthoughtlife
People get fat eating fruits, which are obviously 'natural', and are basically candy. A lot of natural foods fail on the actual criteria (Cashews also fail, for instance.). Does it fill you up? Does it make you not want to keep eating (physical signals)? Are you satisfied enough (psychologically) to be done? Did it give you the nutrients you need (both for your health and to prevent cravings)? Is all of this finished before you ate too many calories?
BDay260

Have you ever seen or even heard of a person who is obese who doesn't eat hyperpalatable foods? (That is, they only eat naturally tasting, unprocessed, "healthy" foods).

This seems like the occam's razor expanation to me. Some of our new flavour/texture combinations are so rewarding that they easily overcome the natural stop signals, leading to excess caloric consumption in most (to a variable degree), which leads to weight gain in some.

A study which gave its participants a 1000cal/day dietary surplus found while some participants gained 14kg of fat over th... (read more)

Have you ever seen or even heard of a person who is obese who doesn't eat hyperpalatable foods? (That is, they only eat naturally tasting, unprocessed, "healthy" foods).

Tried this for many years.  Paleo diet; eating mainly broccoli and turkey; trying to get most of my calories from giant salads.  Nothing.

BDay110

The study I would like to see is giving obese people unlimited access to only natural foods for 3 months. They could add salt and spices, but no oil and definitely no sugar. The diet would be lean(ish) meats, fruits, vegetables and legumes (unsure if allowing nuts is a good idea as they're extremely calorie dense, but technically they should be allowed under this definition). 

I would be surprised if this didn't work. Under this model I view hyperpalatble foods as equivalent to an addictive drug for obese people. Just as if you have a poor phenotype fo... (read more)

BDay50

I have found that bed surface cooling devices like the ChiliPad or Eightsleep Pod Pro are excellent. I have the ChiliPad and noticed better sleep straight away. This includes it being easier to get to sleep, less waking up during the night and waking up in the morning more refreshed. 

Mattresses are great insulators. If it's very cold and you're trying to get warm, they're fantastic. But if it's warm and your body needs to shed heat during the night, they're a problem.

I would recommend these products to anyone who lives in a hot climate and wants to im... (read more)

Answer by BDay30

A lot of commonly sited drug trial prices are risk adjusted, meaning they take into account the high probability of failure, and are thus many multiples higher than the cost of an actual single trial. 

https://pubmed.ncbi.nlm.nih.gov/26908540/#:~:text=A%20Phase%202%20study%20cost,pain%20and%20anesthesia)%20on%20average. 

"A Phase 2 study cost from US$7.0 million (cardiovascular) to US$19.6 million (hematology), whereas a Phase 3 study cost ranged from US$11.5 million (dermatology) to US$52.9 (pain and anesthesia) on average."

Thus, in reality, clini... (read more)