PA has a big advantage over object-level ethics: it never suggested things like "every tenth or so number should be considered impure and treated as zero in calculations", while object-level ethics did. The closes thing I can think of in mathematics, where everyone believed X, and then it turned out not X at all, was the idea that it's impossible to take every elementary integral algorithmically or prove that it's non-elementary. But even that was a within-system statement, not meta-statement, and it has an objective truth value. Systems as whole...
I agree with the first paragraph of the summary, but as for the second - my point is against turning applause lights for utilitarianism on the grounds of such occurrences, or on any grounds whatsoever. And I also observe that ethics haven't gone as far from Bentham as physics have gone from Newton, which I regard as meta-evidence that the existing models are probably insufficient at best.
Is this a bit Silicon Valley Culture? Because those guys do the same - they have a software idea and work on it individually or with 1-2 co-founders. Why? Why not start an open source project and invite contributors from Step 1? Why not throw half-made ideas out in the wild and encourage others to work on them to finish them?
For one thing, because open source community isn't terribly likely to embark on a random poster's new project, and you'll end up developing it mostly by yourself anyway. Furthermore, ...
That's actually surprising: I thought yeast survives freezing reasonably well, and http://www.ncbi.nlm.nih.gov/pmc/articles/PMC182733/?page=2 seems to confirm that. What was different in your setup so that even the control group had a very low survival rate?
Most of my childhood notes and cryo-memrobilia were lost when my house burned down in September, of last year. So, regrettably, I can't consult my notes from those experiments. However, as best I recall, the mortality rate in yeast frozen in distilled water was ~90%. No special treatment was required beyond removing them from the incubating medium and resuspending them in distilled water prior to freezing. Viability was determined indirectly by adding the frozen-thawed yeast in water to culture medium in an Erlenmeyer flask connected to a water displaceme...
Thanks so much for the detailed review and lots of useful reading!
My pleasure!
I have a few (hopefully helpful) comments to add. I am a huge advocate of trying things yourself on a do-able scale. For instance, many years ago I had pretty much the same idea you did and I decided to it out, directly. I lived across the street from a mechanical engineer from Eli Lilly, Inc., named Bud Riever. I asked Bud to figure how much prsssure would be developed if I simply cooled a closed steel container which was completely filled with water to well below the frrezing point? The answer was about 2,000 atmospheres, or about 24,000 psi...
Sure, I can easily imagine that by mentally substituting steel with jello - at some point you're tear it apart no matter how thick the walls are. However, that substitute also gives me the impression that most shapes we would normally consider for a vessel don't reach the maximum strength possible for the material.
Is that done to convert shear force to tension?
I wonder, how much can be achieved by merely increasing the thickness of the walls (even to such extremes as a small hole in a cubic meter of steel)?
Ah, that's true. I guess going back to normal vitals and motion is good enough for preliminary experiments, but of course once that step is over, it's crucial to start examining the effects of preservation on cognitive features of mammals.
Tardigrada and some insects are in fact known to survive ridiculously harsh conditions, freezing (combined with nearly complete dehydration) included. Thus, it makes sense to take a simple organism that isn't known to survive freezing, and make it survive. I suspect though that if you can prevent tardigrades from dehydrating before freezing, the control group won't survive, which means that some experiments can possibly be done on them too.
I'm sure I'm following why mammals should be less susceptible to this problem, can you elaborate?
Doing this with mammals has a lot of challenges though, which it'd make sense to bypass in initial experiments. The deepest dive (aside from humans in DSVs) is only 3km, which accounts for 30 MPa. I guess it's safe to say that no mammal can withstand 350 MPa with air or any gas in its lungs, so total liquid ventilation is required, which is just as challenging to do with sea mammals as with land mammals. Also, mammals are warm-blooded, and usually experience as...
Hmm, I wonder what the exact biochemistry that prevents life forms (including, apparently, vertebrate fish) in Challenger Deep at 111 MPa from experiencing these problems is, and whether it can be replicated in mammals.
They also mentioned that blebbing first appears at 90-120 seconds, but that's way too short even for the fastest protocols possible. Theoretically, it's not unthinkable to cool the body to just above 0C, and then go straight to 632 MPa and above, to make it instantly freeze, before blebbing occurs. And then, if total liquid ventilation allow...
That's an interesting observation! When I was looking into this, I found several suppliers[1][2][3][4] that claim to produce pressure vessels, tubing, and pumps all the way up to 150'000 psi (1GPa). If 300MPa are already pushing the boundaries of steel, do you know what they could use to achieve such pressures?
Yep, fixed that, thanks.
It seems like the approach of cooling the organism to -30C at 350MPa, and then raising pressure further to ~600Mps to freeze it could actually solve that. As far as I understand, the speed of diffusion in water it far slower that the speed of sound (speed of sound at 25C is 1497 m/s, while diffusion coefficient for protons at 25C is 9.31e-5 cm^2/s, which corresponds to 1.4e-4 m/s - 8 orders of magnitude less), which is the speed of pressure gradient propagation. So if we use raising pressure as a way to initiate phase transition, it will occur nearly simul...
That's a very sound (pun partially intended) insight, and I don't immediately see a significant reason for why that shouldn't be the case.
However, humans aren't perfectly uniform spheres of water (to borrow from a common physics joke), so some concerns do still exist. Namely: Pressure might propagate through them less predictably/quickly than just water, and different areas of the body might begin freezing at different pressures/in different orders (which can, however, be countered by raising pressures quickly).
I have updated significantly in the direction of "This idea might actually be very valuable to cryonics proponents," for sure.
If you only observe by absorbing particles, but not emitting them, you can be far enough away so that the light cone of your observation only intersects with the Earth later than the original departure point. That would only change the past of presumably uninhabited areas of space-time.
So where exactly do I go for that? Googling "freeze your cells" gives me the information about technical details of that, rather than a company that provides such service, or completely irrelevant weight loss surgery information.
What is the probability of having afterlife in a non-magical universe?
Aside from the simulation hypothesis (which is essentially another form of a magical universe), there is at leas one possibility for afterlife to exist: human ancestors travel back in time (or discover a way to get information from the past without passing anything back) to mind-upload everyone right before they die. There would be astrong incentive for them to not manifest themselves, as well as tolerate all the preventable suffering around the world: if changing the past leads to killi...
If the effect of RF doesn't go beyond thermal, then you probably shouldn't be concerned about sitting next to an antenna dish any more than about sitting next to light bulb of the equal power. At the same time, even if the effect is purely thermal, it may be different from the light bulb since RF penetrates deeper in tissues, and the organism may or may not react differently to the heat that comes from inside rather than from outside. Or it may not matter - I don't know.
And apparently, there is a noticeable body of research, in which I can poke some holes,...
The general implication is that the so-called truth-seekers are worse off even though the opposite should be true.
The opposite should be true for a rational agent, but humans aren't rational agents, and may or may not benefit from false beliefs. There is some evidence that religion could be beneficial for humans while being completely and utterly false:
http://www.tandfonline.com/doi/abs/10.1080/2153599X.2011.647849
http://www.colorado.edu/philosophy/vstenger/Folly/NewSciGod/De%20Botton.pdf
Should we be concerned about the exposure to RF radiation? I always assumed that no, since it doesn't affect humans beyond heating, but then I found this:
http://www.emfhealthy.com/wp-content/uploads/2014/12/2012SummaryforthePublic.pdf
http://www.sciencedirect.com/science/article/pii/S0160412014001354
The only mechanism they suggest for non-thermal effects is:
changes to protein conformations and binding properties, and an increase in the production of reactive oxygen species (ROS) that may lead to DNA damage (Challis, 2005 and La Vignera et al., 2012)
One ...
OK, I'll have to read deeper into TDT to understand why that happens, currently that seems counterintuitive as heck.
Hypocrisy isn't actually fundamentally wrong, even is deliberate. The idea that it's bad is a final yet arbitrary value that has to be taught to humans. Many religions contain the Golden Rule, which boils down to "don't be a hypocrite", and this is exactly an indicator that is was highly non-obvious before it permeated our culture.
I, for instance, do not think it's okay to kill a copy of me even if I know I will live on
Not OK in what sense - as in morally wrong to kill sapient beings or as terrifying as getting killed? I tend to care more about people who are closer to me, so by induction I will probably care about my copy more than any other human, but I still alieve the experience of getting killed to be fundamentally different and fundamentally more terrifying than the experience of my copy getting killed.
From the linked post:
...The counterargument is also simple, though: Makin
Disclaimer: the identity theory that I actually alieve is the most common intuitionist one, and it's philosophically inconsistent: I regard as death teleportation but not sleeping. This comment, however, is written from System 2 perspective, that can operate even with concepts that I don't alieve
The basic idea behind timeless identity is that "I" can only be meaningfully defined inductively as "an entity that has experience continuity with my current self". Thus, we can safely replace "I value my life" with "I value the e...
We decided that keeping the whole video including personal stories public all the time wouldn't be a very good idea. All the songs, however, are publicly available here: https://www.youtube.com/playlist?list=PLhH76Ztpl1UIHsSvxSsHhoPLc95n_s_6N
My primary concern is that the model is very simplified. Although even on this level it may be interesting to invent a metric for the accuracy of encoding the organism's behavior - from completely random to a complete copy.
When you think about it, the brain is really nothing more than a collection of electrical signals.
Statements like this make me want to bang my head against a wall. No, it is not. Brain is a collection of neural and glial cells, the role of which we only partially understand. Most of the neurons are connected through various types of chemical synapses, and ignoring their chemical nature would fail to explain the effects of most psychoactive drugs and even hormones. Some of the neurons are linked directly. Some of them are myelinated, while others are no...
Agreed this is not brain uploading. Actually this research is not that much different from what has previously been done in computer simulations. The advance is having embedded it in a physical substrate vs a computer.
However, are you implying that C. elegans uploading wouldn't count as uploading because it's so much simpler that a human brain? If so, I disagree with you there. A lot of people think that it would be basically impossible to encode preferences from a C elegans organism (eg learned patterns) into a computer. It certainly hasn't been done yet...
Is there a significant difference between the mathematical universe hypothesis and Hegelian absolute idealism. Both seem to claim the primacy of ideas over matter (mind in case of Hegel, and math in case of MUH), and conclude that matter should follow the law of ideas. MUH just makes one step forward, and says that if there are different kind of maths, there should be different kinds of universes, while Hegel haven't claimed the same about different minds.
Surely I do. The hypothesis that after a certain period of hypoxia under the normal body temperature the brain sustains enough damage so that it cannot be recovered even if you manage to get the heart and other internal organs working is rather arbitrary, but it's backed up by a lot of data. The hypothesis that with the machinery for direct manipulation of molecules, which doesn't contradict our current understanding of physics, we could fix a lot beyond the self-recovery capabilities of the brain is perfectly sensible, but it's just a hypothesis without t...
We may be using different definitions of "care". Mine is exactly how much I'm motivated to change something after I became aware that it exists. I don't find myself extremely motivated to eliminate the suffering of humans, and much less for animals. Therefore, I conclude that my priorities are probably different. Also, at least to some extent I'm either hardwired or conditioned to empathize and help humans in my immediate proximity (although definitely to a smaller extent than people who claim to have sleepless nights after observing the footage ...
How about putting numbers on it? Without doing so, your argument is quite vague.
I would estimate the cumulative probability as the ballpark of 0.1%
Have you actually looked at the relevant LW census numbers for what "we are hoping"?
I was actually referring to the apparent consensus what I see among researchers, but it's indeed vague. I should look up the numbers if they exist.
I would say it's probably no higher than 0.1%.
But by no means I'm arguing against cryonics. I'm arguing for spending more resources on improving it. All sorts of biologists are working on longevity, but very few seem to work on improving vitrification. And I have a strong suspicion that it's not because nothing can be done about it - most of the time I talked to biologists about it, we were able to pinpoint non-trivial research questions in this field.
Secondly, because the people who are in a position to do such research are less likely than the general population to believe in an afterlife.
On this particular point, I would say that people who are in a position to allocate funds for research programs are probably about as likely as the general population to believe in the belief in afterlife.
Generally, I agree - it's definitely not the only problem. The USSR, where people were at least supposed to not believe in afterlife, didn't have longevity research as its top priority. But it's definitely one of the cognitive stop signs, that prevents people from thinking about death hard enough.
Good futurology is different from storytelling in that it tries to make as few assumptions as possible. How many assumptions do we need to allow cryonics to work? Well, a lot.
The true point of no return has to be indeed much later than we believe it to be now. (Besides does it even exist at all? Maybe a super-advanced civilization can collect enough information to backtrack every single process in the universe down to the point of one's death. Or maybe not)
Our vitrification technology is not a secure erase procedure. Pharaohs also thought that their mu
being spoken by "figures wearing black robes, and speaking in a dry, whispering voice, and they are actually withered beings who touched the Stone of Evil"
Isn't that what my inner Quirrellmort supposed to be?
Exactly. Having the official position buried in comments with long chains of references doesn't help to sound convincing compared to a well-formatted (even if misleading) article.
On meta-level, I find it somewhat ironical that LW community, as well as EY, who usually seem to disapprove of oversensitivity displayed by tumblr's social justice community, seem also deeply offended by prejudice against them and a joke that originates from this prejudice. On object-level, the joke Randall makes would have been rather benign and funny (besides, I'm willing to exercise the though that mocking Roko's Basilisk could be used as a strategy against it), if not for the possibility that many people could take it seriously, especially given the ac...
I study at a small campus, that only has grad students of technical majors, more than of whom are international students. There's basically no political or societal discourse on campus. Feels good. I actually get much more exposure to politics via LW meet-ups, and most of the political discourse I interact with comes from local EGL community and their facebook feeds. And reddit, of course. But back on topic, our campus seems to operate on implicit politeness and tolerance principles, which aren't really voiced by anyone.
Did this study consider the difference between white and non-white immigrants to mostly white Western countries?
Did this study consider the difference between white and non-white immigrants to non-white countries?
Did this study consider the difference between immigrants who (try to) assimilate to local communities, and those who prefer to stay within national communities?
I'm not if it works with physical attractiveness, but in case of intellectual adequacy, I'm just not letting any internal doubts in my competence to interfere with external confidence. Even if I suspect that I'm not as smart as people around me, I still act exactly as if I am.
That's the whole point: if we can if we can prevent water from expanding by freezing and keeping the sample under high pressure, thus making crystal formation harmless (probably), we can use less cryoprotectant. I don't know if it's possible to get rid of it completely, so I mentioned wood frogs, that already have all the mechanisms necessary to survive slightly below the freezing temperature. It's just their cryoprotectant isn't good enough to go any colder, but it's not so poisonous either. Also, they're small, so it's easier to find high pressure units ...
That would destroy cryonics companies who make money via insurance that depends on people legally dying.
Wouldn't it just shift to health insurance in this case? But generally, yes, recognizing cryonic patients as alive has a lot of legal ramifications. On the other hand, it provides a much better protection against unfreezing: just like with the patients in a persistent vegetative state, someone authorized has to actively make a decision to kill them, as opposed to no legal protection at all. I'm not sure which of these is the net positive. Besides, tha...
Unfounded self-confidence (or any unfounded belief) is very harmful.
Citation needed. Bluff (i.e. unfounded confidence) seems to be a very efficient strategy in many games. Apparently, even in chess:
UNIDENTIFIED MALE #2: Rook to D1.
CAMPBELL: And this particular move was really bad, and so it caused us to give up the game right away.
FOO: This really bad move confused Kasparov. Murray says he heard Kasparov's team stayed up that night trying to analyze the logic behind that move - what it meant. The only thing was - there was no logic.
Couple of random thoughts about cryonics:
It would actually be better to have cryonics legally recognized as a burial ritual than as a cadaver experimentation. In that way it can be performed on someone who hasn't formally signed a will, granting their body as an anatomical gift to the cryonic service provider. Sure, ideally it should be considered a medical procedure on a living person in a critical condition, but passing such legislation is next to impossible in the foreseeable future, whereas the former sounds quite feasible.
The stabilization procedu
http://philpapers.org/rec/ARGMAA-2 - this may be relevant to your question, although I haven't read the whole article yet.
This article heavily implies that every LessWronger is a preference utilitarian, and values the wellbeing, happiness, and non-suffering of ever sentient (i.e. non-p-zombie) being. Neither of that is fully true for me, and as this ad-hoc survey - https://www.facebook.com/yudkowsky/posts/10152860272949228 - seems to suggest, I may not be alone in that. Namely, I'm actually pretty much OK with animal suffering. I generally don't empathize all that much, but there a lot of even completely selfish reasons to be nice to humans, whereas it's not really the case f...
If nothing breaks, we'll be live here: https://www.youtube.com/watch?v=SpUuPr5gYxk