All of rdb's Comments + Replies

rdb20

Just want to say that a lot of the conversations here are revolving around using our current model of molecular biology to treat cancer. That model has had a ton of success, and is the best workhorse we have for reliably turning money into life-years probably. I think it's a big reason why a lot of people throw that idea around that cancer is gonna be cured by just developing a super-cornucopia of drugs. 

But I think the heart of this post is in asking "well, are there models that get OUT of that framework? ones that are seismic shifts, like the germ t... (read more)

rdb92

This is what I wanted to get at about your post. There are some people/some environments where I feel totally attached to (what I imagine) are people's models of me. I've worried about my mom's judgement for basically all my life. But she can't know me entirely because as you rightly point out, she isn't me — I've felt a lot of comfort in realizing that her model of me (and my model of her modeling me) is necessarily incomplete, and therefore can't be eternally true. My worthiness isn't dependent on her model. If it's any consolation, having this feeling f... (read more)

One thing worth noting is that I have an entanglement between [my defense of my self] and [my defense on behalf of all the Nevilles Longbottom out there].

Like, I have T O N S of evidence that my own "hey, HEY, you don't speak for everybody, bucko!" has been deeply nourishing for lots and lots and lots of people in lots and lots of contexts; even if I were to solve this one completely such that I had no need for self-defense along this axis I would likely still want to push back against the roundings-off on behalf of all the other people who had not yet sol... (read more)

rdb40

In the past post, I would describe my ADHD as "I am in a hurry, in a hurry for what I don't really know".

This is such a great description of what it feels like whenever I'm having trouble focusing. I start to feel this overwhelming feeling of nervous energy, and this thought process like "why am I reading this when there are so many other things I could be reading/doing" and start to crave attention-suckers like social media, etc. Especially as I've been trying to read or learn more challenging things.

rdb10

It doesn't seem to me that obviousness is proof enough that an intuition is good, but something appearing "obvious" in your brain might be a marker/enrich for beliefs that have been selected for in social environments.

There are certainly times when it's good to break universal maxims. Yet I don't think it's very easy to be a person who is capable of doing that -- the divergent individual you're talking about. Let's take lying, for example. It is generally good to be honest. There are times when it is really net good and useful to lie. But if you're someone... (read more)

rdb50

A few for cell biology:

  • How do we measure what proteins, and other biomolecules, are actually doing in a native context? For tracking where proteins are in the cell: sure, we can pop GFP onto anything we'd like, but now we have a protein that's lugging around a ~20 kilodalton tube on its back. That's got to be skewing that protein's behavior somewhat.
  • Cell signalling as needing a true name. Biologists talk about cell signalling all the time, but the physical mechanisms by which information is propagated in a cell seem incredibly variable. In a lot of mechani
... (read more)