I'm a little late to the game here, but I have a small issue with the above.
I don't think it is accurate to estimate the size of changes in such a manner, as there is an enormous complex of transcription factors that create interplay between small changes, ones of which we may never see any actual trace or are located outside the genome that affect the genome. SNPs are important (such as those in FOXp2) but not the be all end all factor for those expressions as well - epigenetic factors can drive selection just as effectively as chance mutation creates adv
I'm a little late to the game here, but I have a small issue with the above.
I don't think it is accurate to estimate the size of changes in such a manner, as there is an enormous complex of transcription factors that create interplay between small changes, ones of which we may never see any actual trace or are located outside the genome that affect the genome. SNPs are important (such as those in FOXp2) but not the be all end all factor for those expressions as well - epigenetic factors can drive selection just as effectively as chance mutation creates adv
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