Background
@jkaufman wrote a nice post on the progress of C elegans modeling effort in 2011, with a followup post in 2014. Here we are, almost a decade later, and I still have the same question that I would have asked even in 2011 if I had dived into the project.
Question
Considering that we do not know the signs of the connectome weights, what do you think about the strength of explanations that try to explain biological phenomenon (E.g. locomotion) in terms of neural dynamics (e.g. from this model, we propose that there's push-pull circuitry because we see that our model shows these fluctuating membrane potentials)?
My preliminary take: Weak and highly uncertain.
Cook et al., 2019... (read more)
Hi David, thanks much for the post. Can you comment on the rationales behind moving away (because of funding?) from C elegans? In particular, I'm interested in your thoughts on these points:
I'm asking this out of pure curiosity, as a software engineer who just started diving into C elegans simulations.