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twanvl comments on A survey of anti-cryonics writing - Less Wrong
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The difference between cryonics and, for example, global warming denialism is that the former makes a claim like "it is probably a good thing to do X", while the latter makes a claim like "X is/is not true". These are completely different things!
Perhaps it is better to compare it to the anti vaccine movement. They do make a claim of the form "X is good/bad for you". Now the difference becomes about evidence. For cryonics there is little evidence either way: it has never worked, and it has never not-worked. In such a case there is little we can do beyond trying to use reason alone (always a dangerous thing) and waiting for more experiments.
On the other hand, there is a lot of evidence that vaccines work just fine. Denying that evidence is wrong.
Your definition of evidence is too narrow.
Why is it a sin to deny a lot of evidence, but not a little evidence?
Because the less evidence there is, the better the chance that we're mistaken about it, all else equal. But this seems obvious enough that I guess I'm missing your point.
Sure, the weaker the evidence, the less you'll be misled on average by ignoring it. But there doesn't come a point where ignoring evidence is not misleading at all compared to updating on it. It's never going to be a good idea to start saying to yourself "that's only a little bit of evidence, so I'll just pretend it wasn't there".
If updating were costless, I'd agree.