See here.

Caloric restriction clearly can benefit the average American. The verdict is out on whether this is only because the average American has such an awful diet that decreasing consumption necessarily decreases consumption of an awful diet; however, the additional evidence from other species combines to be pretty compelling in my mind.

I don't partake in chronic caloric restriction, but I fast occasionally, ideally as much as I can while maintaining the amount of muscle that I like to keep, and without dropping my productivity levels. The evidence in favor of the health benefits of intermittent fasting seems slightly better than CR, although I believe it is only beginning to get more attention in research.