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nhamann comments on Open Thread: May 2010 - Less Wrong
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Does anyone know the relative merits of folding@home and rosetta@home, which I currently run? I don't understand enough of the science involved to compare them, yet I would like to contribute to the project which is likely to be more important. I found this page, which explains the differences between the projects (and has some information about other distributed computing projects), but I'm still not sure what to think about which project I should prefer to run.
Personally I run Rosetta@home because, based on my research, it could be more useful to designing new proteins and computationally predicting the function of proteins. Folding seems to be more about understanding how they proteins fold, which can help with some diseases, but isn't nearly the game changing that in silico design and shape prediction would be.
I also think that the SENS Foundation (Aubrey de Grey & co) have some ties to Rosetta, and might use it in the future to design some proteins.
I'm a member of the Lifeboat Foundation team: http://lifeboat.com/ex/rosetta.home
But we could also create a Less Wrong team if there's enough interest.