In my case, to name one contingency: if the NEMALOAD Project finds that analysis of relatively large cellular structures doesn't suffice to predict neuronal activity, and concludes that the activity of individual molecules is essential to the process, then I'd become significantly more worried about EHeller's objection and redo the cost-benefit calculation I did before signing up for cryonics. (It came out in favor, using my best-guess probability of success between 1 and 5 percent; but it wouldn't have trumped the cost at, say, 0.1%.)

To name another: if the BPF shows that cryopreservation makes a hash of synaptic connections, I'd explicitly re-do the cost-benefit calculation as well.