Presumably you can use google and wikipedia to fill in the gaps just like the rest of us.
Long-term memory, unlike short-term memory, is dependent upon the construction of new proteins.[30] This occurs within the cellular body, and concerns in particular transmitters, receptors, and new synapse pathways that reinforce the communicative strength between neurons. The production of new proteins devoted to synapse reinforcement is triggered after the release of certain signaling substances (such as calcium within hippocampal neurons) in the cell. In the case of hippocampal cells, this release is dependent upon the expulsion of magnesium (a binding molecule) that is expelled after significant and repetitive synaptic signaling. The temporary expulsion of magnesium frees NMDA receptors to release calcium in the cell, a signal that leads to gene transcription and the construction of reinforcing proteins.[31] For more information, see long-term potentiation (LTP).
One of the newly synthesized proteins in LTP is also critical for maintaining long-term memory. This protein is an autonomously active form of the enzyme protein kinase C (PKC), known as PKMζ. PKMζ maintains the activity-dependent enhancement of synaptic strength and inhibiting PKMζ erases established long-term memories, without affecting short-term memory or, once the inhibitor is eliminated, the ability to encode and store new long-term memories is restored.
Also, BDNF is important for the persistence of long-term memories.[32]
What I worry about being confused on when reading the literature is the distinction between forming memories in the first place, and actually encoding for memory.
Another critical distinction is that, proteins that are needed to prevent degradation of memories over time (which get lots of research and emphasis in the literature due to their role in preventing degenerative diseases) aren't necessarily the ones directly encoding for the memories.
So in subjects I know a lot about, I have dealt with many people who pick up strange notions by filling in the gaps from google and wikipedia with a weak foundation. The work required to effectively figure out what specific damage to the specific proteins you mentioned could be done by desiccation of a cell is beyond my knowledge base, so I leave it to someone more knowledgeable than myself(perhaps you?) to step in.
What open/closed states does PKMζ have? What regulates those open/closed states? Are the open/closed states important to its roll (it looks like yes given the notion of the inhibitor?)?
If you've recently joined the Less Wrong community, please leave a comment here and introduce yourself. We'd love to know who you are, what you're doing, what you value, how you came to identify as a rationalist or how you found us. You can skip right to that if you like; the rest of this post consists of a few things you might find helpful. More can be found at the FAQ.
A few notes about the site mechanics
A few notes about the community
If English is not your first language, don't let that make you afraid to post or comment. You can get English help on Discussion- or Main-level posts by sending a PM to one of the following users (use the "send message" link on the upper right of their user page). Either put the text of the post in the PM, or just say that you'd like English help and you'll get a response with an email address.
* Normal_Anomaly
* Randaly
* shokwave
* Barry Cotter
A note for theists: you will find the Less Wrong community to be predominantly atheist, though not completely so, and most of us are genuinely respectful of religious people who keep the usual community norms. It's worth saying that we might think religion is off-topic in some places where you think it's on-topic, so be thoughtful about where and how you start explicitly talking about it; some of us are happy to talk about religion, some of us aren't interested. Bear in mind that many of us really, truly have given full consideration to theistic claims and found them to be false, so starting with the most common arguments is pretty likely just to annoy people. Anyhow, it's absolutely OK to mention that you're religious in your welcome post and to invite a discussion there.
A list of some posts that are pretty awesome
I recommend the major sequences to everybody, but I realize how daunting they look at first. So for purposes of immediate gratification, the following posts are particularly interesting/illuminating/provocative and don't require any previous reading:
More suggestions are welcome! Or just check out the top-rated posts from the history of Less Wrong. Most posts at +50 or more are well worth your time.
Welcome to Less Wrong, and we look forward to hearing from you throughout the site.