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zacharyalain comments on Seeking examples of people smarter than me who got hung up - Less Wrong
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Look up the "Nobel Syndrome," e.g. here: http://scienceblogs.com/insolence/2010/11/23/luc-montagnier-the-nobel-disease-strikes/"
And yeah, Linus Pauling.
On a more sinister level, there are people like Peter Duesberg: http://en.wikipedia.org/wiki/Peter_Duesberg