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mare-of-night comments on Lifestyle interventions to increase longevity - Less Wrong
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I remember seeing another LW member comment that over-the-counter drugs tend to get sold in too-high dosages because people who don't know how to dose (most customers) assume the strongest is best, and the stores stock the versions that are selling best, leading to doses that are too high for the typical user being the most commonly sold ones. I don't remember where the original comment was, unfortunately.
That makes sense but doesn't actually answer my question. The phrasing implied (to me) that either the smaller dose works better or that the larger has more side effects, without specifying which. I've tried 1mg pills and they didn't seem to work as well, but I'm not sure if that was placebo talking or not.
For many smaller doses do work better than larger doses, though I don't have the cite handy. Better to start too small and work up than the other way around IMO. When I took large doses I had negative side effects.
Does the word "cite" mean that you have seen a controlled study claiming that smaller doses are more effective than large doses, and not just anecdotes?
Yes. or at the very least there were issues with side effects and tolerance building.
This is a press release, but might be a pointer in the direction of the study.
this is the insomnia study for that press release
This makes sense. I don't know the answer, though.