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James_Miller comments on Lifestyle interventions to increase longevity - Less Wrong

120 Post author: RomeoStevens 28 February 2014 06:28AM

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Comment author: James_Miller 27 February 2014 07:18:19PM 5 points [-]

Examine.com is much less positive about CoQ10 writing "all the noticeable effects (more vitality) could potentially be placebo. It is very much a faith buy and the costs if you take it in the wrong manner (without a fatty transport) could be quite high financially."

Comment author: RomeoStevens 27 February 2014 11:00:38PM 3 points [-]

mean decrease in systolic pressure over 8 studies of 16mm Hg kicks the crap out of a lot of interventions, including some prescription ones.

Comment author: PeterDonis 01 March 2014 04:09:55AM 0 points [-]

Are there any theories about the mechanism involved here? I've done a fair bit of Googling about this but haven't found any discussion of underlying mechanisms, only the statistics. I know that CoQ10 is critical in the metabolic cycle that produces ATP, and therefore is involved in energy production everywhere in the body; but I'm not sure how to get from that to the specific result of lowering blood pressure (rather than something more general like "feel more energetic").

Comment author: RomeoStevens 01 March 2014 08:06:28AM 0 points [-]

The fact that blood pressure is an independent predictor of mortality would imply it affects, and is most likely affected by, a lot of metabolic processes.

Comment author: CellBioGuy 28 February 2014 05:03:23AM 2 points [-]

From my own looking around I would recommend adding CoQ10 if you are on statin anti-cholesterol medications. They interfere with its recycling within your body, and while there's a reason that the active part of CoQ10 is called 'ubiquinone' (its in EVERYTHING that was once alive) its plausible that levels might drop enough to mess with higher metabolic levels if you are on these drugs. Source: anecdotal evidence and a recent study that seemed to show that statin drugs cause people to stop getting cardiovascular benefits from aerobic exercise.