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hyporational comments on Open thread, Dec. 22 - Dec. 28, 2014 - Less Wrong
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The hippocampus is a relatively tiny structure in the human brain, and I would guess it's even proportionally smaller in the mouse brain. I doubt the corresponding decrease in cerebrospinal fluid volume would make any difference in function. There's already much more variation in cerebrospinal fluid volume in healthy humans than a 20% increase in hippocampal volume could account for.