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Andy_McKenzie comments on We Haven't Uploaded Worms - Less Wrong
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Agreed, and this is very similar to what I described in my comment on the other post about this here.
Where I disagree is the sole focus on connection strengths or weights. They are certainly important, but synapses are unlikely to be adequately described by just one parameter. Further, local effects like neuropeptides likely play a role.
You're right: connection strengths are probably not enough on their own. On the other hand, they're almost certainly necessary and no one has figured out how to read them off of synapses.