I've run in to the argument that cryonics beats VillageReach on a simple "shut up and multiply" level, by assuming an infinity vs finite tradeoff. Having read the Fun Theory sequences, it struck me that this wasn't a reasonable assumption, so I sat down, re-read a few relevant posts, shut up, and multiplied.
In Continuous Improvement, Eliezer ballparks a good fun-theory life as having a maximum length of around 28,000 years. In Robin Hanson's Cryonics Probability Breakdown, he assigns cryonics a conjoint probability of about 6%. 28,000 * 0.06 gives us a net return of 1,680 expected years.
Full body suspension from the Cryonics Institute currently costs $28,000.
VillageReach, according to GiveWell, can save an infant's life for less than $1,000.
For the price of Cryonics, we thus save 28 lives. 1680 expected years, divided by 28, puts the break-even point at an average lifespan of 60 years for those infants saved. A quick peak at Wikipedia suggests that the average African life is under 60 years for the majority of the continent, although there are some important nuances to really get a full picture.
Obviously, these are rough numbers, and I doubt many people base their decisions solely on "years lived". I do find it rather interesting that cryonics is currently about on par with one of the most effective charities in the world on that metric, however :)
Also, donating to VillageReach saves people's lives, and those people will have agency and abilities and may very well contribute to existential risk reduction.
But they may also contribute to existential risk increase. What sort of calculation have you made that makes you think these people are more likely to contribute to existential risk increase?
I don't think I've seen any reasonable argument that can be made that simply having more random people around will help deal with existential risk. Most likely existential risks (UFAI, grey goo, bioterrorism, whatever) will be caused by people afterall.