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My experience with giving people the data behind squatting to go to the dunny is that their awkwardness about it strongly outweighs, initially, their willingness to experiment.
Which leads to the thought that there are probably some provably life-enhancing things that people don't even consider doing because it is so far outside their social mores that the possibility doesn't occur. I have had an entertaining few minutes trying to think of some that my great-descendants will be bewildered we didn't consider.
Fecal transplants and cryonics.