Reification seems at work in the studies of the placebo effect for antidepressants. It's found that except for severe depressions, antidepressants may have "little or no greater benefit than placebo." The conclusion drawn is either that antidepressants aren't effective or placebos are effective, when the truth is that most depressions have a short-term course, and the placebo group's effects include the spontaneous remissions.