ACXLW Longevity (special guest speaker) 9/2/23

https://docs.google.com/document/d/1wu69N0x-dvEN3NImEDCEZfd0MOeCQe6cS4AolAdiCuc/edit?usp=sharing

Hello Folks!

We are excited to announce the 41st Orange County ACX/LW meetup, happening this Saturday and most Saturdays thereafter.

Host: Michael Michalchik

Email: michaelmichalchik@gmail.com (For questions or requests)

Location: 1970 Port Laurent Place 

(949) 375-2045

Date: Saturday, Sept 2, 2023

Time: 2 PM

This Saturday we are fortunate to have a special guest speaker, Professor Michael Rose, one of the leading researchers in the world on the evolution of aging and scientific strategies for health and life extension. His experiments and analysis point towards a heterodox approach to human life extension that has immediate implications on lifestyle and that provides a new scientific paradigm to develop advanced life extension technologies. 

Please read the following outline of his research and approach to healthy long life, and bring your questions, comments, and criticisms for the presentation and lively discussion that will follow.

This link is the summary:

https://55theses.org/the-55-theses/

The full text starts on this web page and continues on linked pages in the sidebar:

 

https://55theses.org/2011/03/18/thesis-1/

Or, if you want the 55 theses on evolutionary strategies for aging and commentary, a full-length PDF is here:

https://michaelroses55.files.wordpress.com/2011/05/55-theses-explained-final.pdf

A 20 minute audio is available here:

https://youtu.be/vd6Dm978dbg?si=_X6noVVrCKw9T-tD

Embracing the power of evolution to stop aging | Dr. Michael Rose

• Walk & Talk: We usually have an hour-long walk and talk after the meeting starts. Two mini-malls with hot takeout food are easily accessible nearby. Search for Gelson's or Pavilions in the zip code 92660.
• Share a Surprise: Tell the group about something unexpected that changed your perspective on the universe.
• Future Direction Ideas: Contribute ideas for the group's future direction, including topics, meeting types, activities, etc.

Here is a summary from Claude 2:

Aging as a Decline in Adaptation

• Aging reflects a progressive decline in adaptation due to weakening natural selection after the onset of reproduction, not inherent biochemical deterioration. Some organisms exhibit no senescence, demonstrating that aging is not inevitable.

Experimental Evolution of Aging

• Shifting onset of reproduction in fruit flies quickly changes lifespan and aging rates, demonstrating the malleability of aging by altering natural selection.

Role of Natural Selection in Patterns of Aging

• Comparative biology reveals correlations between ecological mortality factors and aging rates, evidencing the role of natural selection in shaping aging.

Human Aging in Evolutionary Context

• Humans likely evolved slow aging due to reduced extrinsic mortality from tools, hunting, and sociality attenuating the age-dependent decline in the forces of natural selection.

Impact of Agriculture on Human Aging

• Agriculture initially decreased health but populations adapted genetically to cereal and milk diets, primarily during high selection pressure juvenile phases. Older adults retain poor adaptation to agriculture.

Cessation of Aging

• There is a late-life cessation of aging where mortality/fertility plateaus due to negligible natural selection. Some populations may exhibit early cessation, investigable with hunter-gatherer lifestyles and medicine. Experiments shifting cessation of reproduction alter timing of aging cessation in flies, demonstrating it is evolvable.

Antagonistic Pleiotropy

• Trade-offs between early reproduction and late survival due to antagonistic pleiotropy of genetic variants accelerate senescence. Natural selection favors sacrificing later health for early fertility due to asymmetric forces of natural selection declining with age.

Evolutionary Basis for Life Extension

• Evolutionary experimental research provides the strongest framework for understanding the plasticity of aging rates and cessation. Mainstream molecular damage theories inadequately explain aging. Aging should be understood as an evolvable decline in adaptation amenable to genetic and environmental manipulation.