Answers to these questions should be expressed numerically, where possible, but no number should be given without a justification for the specific value.
1. Suppose that you have mislaid your house keys, something most people have experienced at one time or another. You look in various places for them: where you remember having them last, places you've been recently, places they should be, places they shouldn't be, places they couldn't be, places you've looked already, and so on. Eventually, you find them and stop looking.
Every time you looked somewhere, you were testing a hypothesis about their location. You may have looked in a hundred places before finding them.
As a piece of scientific research to answer the question "where are my keys?", this procedure has massive methodological flaws. You tested a hundred hypotheses before finding one that the data supported, ignoring every failed hypothesis. You really wanted each of these hypotheses in turn to be true, and made no attempt to avoid bias. You stopped collecting data the moment a hypothesis was confirmed. When you were running out of ideas to test, you frantically thought up some more. You repeated some failed experiments in the hope of getting a different result. Multiple hypotheses, file drawer effect, motivated cognition, motivated stopping, researcher degrees of freedom, remining of old data: there is hardly a methodological sin you have not committed.
(a) Should these considerations modify your confidence or anyone else's that you have in fact found your keys? If not, why not, and if so, what correction is required?
(b) Should these considerations affect your subsequent decisions (e.g. to go out, locking the door behind you)?
2. You have a lottery ticket. (Of course, you are far too sensible to ever buy such a thing, but nevertheless suppose that you have one. Maybe it was an unexpected free gift with your groceries.) The lottery is to be drawn later that day, the results available from a web site whose brief URL is printed on the ticket. You calculate a chance of about 1 in 100 million of a prize worth getting excited about.
(a) Once the lottery results are out, do you check your ticket? Why, or why not?
(b) Suppose that you do, and it appears that you have won a very large sum of money. But you remember that the prior chance of this happening was 1 in 100 million. How confident are you at this point that you have won? What alternative hypotheses are also raised to your attention by the experience of observing the coincidence of the numbers on your ticket and the numbers on the lottery web site?
(c) Suppose that you go through the steps of contacting the lottery organisers to make a claim, having them verify the ticket, collecting the prize, seeing your own bank confirm the deposit, and using the money in whatever way you think best. At what point, if any, do you become confident that you really did win the lottery? If never, what alternative hypotheses are you still seriously entertaining, to the extent of acting differently on account of them?
I think a lot of probabilistic and behavioral reasoning starts to break down and act strangely in the presence of very large odds ratios.
For example, if I discover that I have won the lottery, how should I estimate the probability that I am hallucinating, or dreaming, or insane? In the first case, I cannot trust the evidence of my senses, but I can still reason about that evidence, so I should at least be able to work out a P(hallucination). In the second case, my memory and reasoning faculties are probably significantly impaired, BUT any actions I take will actually have no effect on the world, so I should consider this case when computing questions about truth, but IGNORE it when computing questions about action. In the third case, it's likely that I can't even reason coherently, so it's not clear how to weigh this state at all. Conditional on being in it, my reasoning is questionable; conditional on my being able to reason about probabilities, I'm very likely (how likely?) not in it; therefore when reasoning about how to behave, I should probably discount it by what seems to be a sort of anthropic reasoning.
So whatever the probabilities are that I can't trust my senses / that I can't trust my own reasoning abilities, it's going to be very hard for me to reason directly about probabilities more extreme than that in many cases.