So Scott Alexander's post at http://slatestarcodex.com/2016/03/01/2016-nootropics-survey-results/ shows that the most "effective" "nootropics" have still been the ones that have existed for a long time. What do these results really mean, though? Is it possible that people are just worse at noticing the subtler effects of the other drugs, or are just much worse at disciplining themselves enough to correctly use the racetams or noopept (as in, with choline)?
How much potential is there in innovation in nootropics? What is holding this innovation back, if anything? It feels like there hasn't been any real progress over the last 15 years (other than massively increased awareness), but could targeted drug discovery (along with people willing to be super-liberal with their experimentation) finally lead to some real breakthroughs?
I believe CronoDAS is referring to Algernon's Law. Gwern describes the issues pretty well here, including several classes on "loopholes" we might employ to escape the general rule.
The classifications of different types of loopholes is still pretty high level, and I'd love to see some more concrete and actionable proposals. So, don't take this as saying "this is old hat", but only as a jumping off point for further discussion.