To produce a vaccine, you will need at least:
In biopharmaceutical production you have two kind of extremes in the facility design:
Of course, everything between those two designs is possible. Both types can be designed to produce multiple products which is referred to as a "multi-product facility". Depending on the automation grade you will need more or less staff with more or less training and experience. For the ramp-up of the facility and for ongoing troubleshooting you will need (highly) educated stuff.
The vaccine production systems can be roughly classified into these variants:
These outlined systems are quite different, and, therefore, the facilities will look different. However, a well-designed multi-product facility should be able to cover a wide range of the possible vaccine types because basic fluid handling and a lot of other steps are similar.
The most similar historical equivalent I can think of is the penicillin production, although there the circumstance where quite different.
Vaccines are one of the most cost-effective medical preventive measures but usually the margins are thin. This is why the investments in such products has not seen the levels of treatments of civilization diseases, e.g., cancer or diabetes.
Edit: Added large scale process to the points at the beginning.
There seem to be different technologies that can produce vaccines. On the one hand there's an old-fashionated way to create vaccines.
Then there are multiple different companies that make mRNA-based vaccines and as far as I understand they all use different technology to do so and are therefore not easily exchangable.
CureVac announced that they got a 80 million Euro loan from the EU that they use to build a facility that can produce ~1,000,000,000 doses of a possible vaccine if the dose is equal to what they found to be needed for their rapies vaccine candidate.
Moderna who started their human trial on March 16th made a SEC filing in which they wrote:
On March 20, 2020, Stephane Bancel, CEO of Moderna, was interviewed by representatives of Goldman Sachs regarding the Company’s work onCOVID-19. During such interview, Mr. Bancel indicated that while a commercially-available vaccine is not likely to be available for at least 12-18months, it is possible that under emergency use, a vaccine could be available to some people, possibly including healthcare professionals, in the fall of2020. In addition, Mr. Bancel confirmed that the Company is scaling up manufacturing capacity toward the production of millions of doses per month,in the potential form of individual or multi-dose vials. As has previously been disclosed, the ability of the Company to make millions of doses per month is contingent on investments in the scale up and further buildout of the Company’s existing manufacturing infrastructure.
I would predict that if Moderna starts giving out a million vaccines to health workers under emergency use any additional doses of vaccines they produce would also find willing patients whether or not the drug is offically commercially-available. Politically it wouldn't be defensible to let millions of doses of a vaccines that's good enough for health workers to lie around.
The highlited passage looks to me like Moderna needs cash to scale up their production.
According to the main investor in CureVac, there current plan is to make the vaccine generally available at the end of the year:
micpie's answer here is good! I don't have a lot to add to it.
Here are a few related reference-links* and a tiny bit of commentary.
*...some of which I heard about via other micpie comments. Go figure.
** 60 days from the nCOV DNA sequence to mRNA vaccines starting clinical trials! mRNA is a relatively flexible/easy-to-modify platform, but new and a bit untested.
From this comment on a post to which I recently linked on this site:
Also: I don't know if you saw the article, but it's not just gardening supplies that have been wiped out. America's run through all the baby chickens too.
So, as a sort of sub-question to this one:
What are the costs, benefits, and logistics of opening new facilities for the entire supply chain for vaccine facilities?
In this comment on the parent question, David Manheim makes the case for building new vaccine production facilities before we have a vaccine ready to produce, and for this to be subsidized. I find this question interesting in its own right, but it's also an opportunity to dig into the nitty-gritty of producing something, which I wish happened more on LessWrong. I don't expect this to lead directly to a vaccine facility coming into existence- presumably the people who have the power to do that already have access to the knowledge as well- but I think it's a useful exercise in how things actually get done.
To recap, David's argument as I understand it is:
There's already a great discussion of this in the replies to his thread, and I encourage you to read it before commenting here. Some questions that came up in that discussion:
Some additional questions I have are: