The Open Thread posted at the beginning of the month has gotten really, really big, so I've gone ahead and made another one. Post your new discussions here!
This thread is for the discussion of Less Wrong topics that have not appeared in recent posts. If a discussion gets unwieldy, celebrate by turning it into a top-level post.
Depends on which details actually need to be simulated. I suspect that most intracellular activity can be neglected or replaced with some simple rules on when a cell divides, adds a synapse, etc.
For the record, this is something I don't have much confidence in - WBE requires a sufficiently detailed brain scan, computers of sufficient processing power to run the simulation, and enough knowledge of brains on the microscopic level to program a simulation and understand the output of the simulation. I do not know which will turn out to be the bottleneck in the process.