See also: Boring Advice Repository, Solved Problems Repository, Grad Student Advice Repository
I often find that my understanding of the world is strongly informed by a few key concepts. For example, I've repeatedly found the concept of opportunity cost to be a useful frame. My previous post on privileging the question is in some sense about the opportunity cost of paying attention to certain kinds of questions (namely that you don't get to use that attention on other kinds of questions). Efficient charity can also be thought of in terms of the opportunity cost of donating inefficiently to charity. I've also found the concept of incentive structure very useful for thinking about the behavior of groups of people in aggregate (see perverse incentive).
I'd like people to use this thread to post examples of concepts they've found particularly useful for understanding the world. I'm personally more interested in concepts that don't come from the Sequences, but comments describing a concept from the Sequences and explaining why you've found it useful may help people new to the Sequences. ("Useful" should be interpreted broadly: a concept specific to a particular field might be useful more generally as a metaphor.)
I'm personally a fan of tabu search, which prevents cycling and getting stuck in local optima by remembering features of previously seen solutions, and not visiting any solution with those features for some set length of time. "Best" depends on the particular problem, though; there are situations when the easy implementation of simulated annealing makes it a superior solution to a cleverer but longer implementation of something else.