5hout

That's a very good question. Unfortunately the answer is nearly undefined/very high variance depending on the person undergoing the weight loss. There's a huge range of expected outcomes depending on history and weight loss plan.

Ideal case might be Neutral LBM: Fairly obese youngish person. No training history (say someone that was super active, but not athletic, in HS). Goes to college, walks a ton stays pretty skinny. Gets first desk job around 25-26 and gains a ton of weight. Holds onto the weight, without much activity for 2-3 years. Diets in the most careful sense (.5% of bodyweight per week for 3-5 weeks then a maintenance week, macros on point, heavy resistance... (read 430 more words →)

Replying toSemaglutide and Muscle

No disagreement from me :)

Replying toSemaglutide and Muscle

If you are interested in this drug to lose weight go very carefully. You might lose weight, but be plausibly more likely to get type 2 beetus at the end.

Replying toSemaglutide and Muscle

Not to my knowledge. There's a handful of studies that are pretty superficial (i.e. people come in for some DEXA (body composition) scans and that's it. I think it's going to take some time, because anyone involved in seeking approval of the drug has a huge negative incentive to look in this box, given the at least plausibly neutral results from the first supportive studies.

I think the place to look for citizen science on this is going to be in the longevity community and similar areas where you have people semi-openly experimenting with what is sometimes colloquially called "sports TRT" (i.e. running a testosterone only steroid cycle with modest amounts compared to... (read more)

Replying toSemaglutide and Muscle

Breaking my thoughts to your comment into 4 parts.

1: "Were you to follow your advice of "days of eating right, sleeping right and training for every single day of over eating" - which people who are obese have tried for decades and achieving normal BMI is rare - how is this mechanically different? Eating right means smaller meals and eating less kcals than daily metabolic needs"

All these using Freedom Units:

I've cut from >230 (I think peak around 245/250) to under 190 2 times with a 3rd 30 pound cut snuck in there. Going off Friday afternoon memory:
2013: >230 (Graduated law school, moved back to home state)
2014:<190 (insane caloric restriction combined with dumb... (read 675 more words →)

5hout

tl;dr Semaglutide seems to have muscle loss effects that may entirely wash out the benefits of Beetus (Type 2) prevention and leave you at a lower bodyweight (but possibly worse off for longevity) than you were before.

There are very few things the rationalist community likes more than a new science answer to one of life's problems. If this new answer is a drug, “research chemical” or supplement so much that better. People have been super excited about Semaglutide (Wegovy/Ozempic) since it was approved for weight loss in 2021. One problem that has been discussed, but seems to be pushed under the rug (in a rush to let a drug rewire your brain... (read 1215 more words →)

I've heard a lot of soccer leagues are taking steps to address headers, but afaik, it's a bit of a false lead b/c (and this is weak knowledge) a lot of the concussions are not header related. Happily, your kids didn't want to play it so doesn't matter much.

Boxing is such an odd sport in the modern context. I'd also add that you should be wary of some other MAs like TKD, as depending on the exact ruleset there can be an extreme focus on kicks to the head.

While I disagree, I can see why you would make that choice. Personally I stopped doing MAs when I realized I just really didn't like getting hit in the face.

Seems reasonable. I think the variance MA school to MA school is so incredibly high that it's almost impossible to layout a plan other than "visit schools within a reasonable trip and see".

Fair enough. Certainly schools have that, other schools have different cultures as well (but I'd guess the average is closer to your thought). Likely a different vibe from track/cross-country and marching band for sure. (Which isn't too say you don't have people that crossover/differences).