CBorys
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Probably the question of Multiverse- versus Collapse-Interpretation in Quantum Physics could suffice. It fits your needs as a factual and, somewhat, important question, while there is no overall aggreement in the respective fields of experts (although the trend to MI seems becoming clear...). Furthermore I guess there aren't any status- or mindkilling-issues concerning this question, but, and that might rule out this question at least in some cases, a religious person might feel otherwise and reject the idea of "multiple creations" at first sight. Regarding "High uncertainty" the MI/CI-conflict might not fit your scheme, as(you already know if you read the Quantum-Physics-Sequence) there is a strong Bayesian argument to decide for Multiverse-Interpretation, but... (read more)
I thought it to be a nice illustration: Dawkins vs. Tyson This is a 2-minute-excerpt of "Beyond Belief", where Tyson accuses Dawkins of "the first type of winning an argument". (But his answer is no more than "You're right. But some people are worse".)