I've never heard of cyclic peptides. But I suppose it is possible. 

Actually the HPLC study we cite talks about a similar possibility - they say the observed effects may be due to "cryptic peptides", perhaps created by the lysing of larger proteins and peptides. It just seems very unlikely to me. To me, based on my metascience research, it's a it easier to believe that the published literature is just plain wrong. Check out the HPLC paper - it's he only we found doing that sort of analysis but it's very detailed (https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/dta.1817). 

In the case of Bryan Johnson he injected it in his glute. Others inject in the thigh (there's a how-to video about this on YouTube). Apparently some biohackers online think that by injecting in the shoulder more will reach the brain, because the shoulder is closer to the head, according to a podcast I listened to LOL (the podcaster agreed this made a lot of sense). 

Uh this is kinda embarrassing but I just didn't really read it at all honestly.. 

Q: when was prion disease discovered

A: "Prion disease was first recognized as a distinct category of neurodegenerative disorders in the 1980s, though the groundwork for its discovery was laid earlier.

Key milestones in the discovery of prion diseases include:

1. 1920s: Creutzfeldt-Jakob Disease (CJD) was first described by Hans Gerhard Creutzfeldt and Alfons Maria Jakob.
2. 1950s: Carleton Gajdusek began studying kuru, a disease affecting the Fore people of Papua New Guinea.
3. 1960s: Gajdusek demonstrated that kuru could be transmitted to chimpanzees, suggesting an infectious etiology.
4. 1982: Stanley Prusiner coined the term "prion" (for proteinaceous infectious particle) and proposed the protein-only hypothesis for these infectious agents.
5. 1997: Prusiner was awarded the Nobel Prize in Physiology or Medicine for his work on prions.

The concept of prions as the causative agents of these diseases was revolutionary because it challenged the central dogma of biology, suggesting that proteins alone, without nucleic acids, could be infectious.

Would you like me to elaborate on any specific aspect of prion disease discovery?"
 

You have an eagle eye Carl!... I actually asked Claude (the AI) about this when I was writing it, but I was very sloppy and didn't read Claude's answer carefully. Just fixed it. I should be more careful..

Great, I look forward to meeting you there!

hah... actually not a bad idea... too late now. BTW the recording will be available eventually if you're interested.

Hi, organizer here. I just saw your message now right after the event. There were a couple people from Microsoft there but I'm not sure if they were interested in alignment research. This was mostly a general audience at this event, mostly coming through the website AIcamp.ai. We also had some people from the local ACX meetup and transhumanist meetup. PS: I sent you an invitation to connect on LinkedIN, let's stay in touch (I'm https://www.linkedin.com/in/danielelton/). 

Unfortunately they have a policy that they check ID at the door and only allow those over 21 in. I'm going to update the post now to make this clear. Even when the outdoor patio is open it's still only 21+. 

The way I would describe it now is there's a large bar in the main room, and then there's a side room (which is also quite large) with a place that serves Venezeualian Food (very good), and Somerville Chocolate (they make and sell chocolate there).  

The age restriction has never been a problem in the past although I do vaguely recall someone mentioning it once.  I'm going to try to have future meetups I run at a public library (probably Cambridge Public Library), its just tricky getting the room reservations sometimes. We have been thinking of trying out the food court in Cambrideside mall, also, although the tables there are rather small and I don't think they can be moved and joined together (from what I remember). 

Sorry for the late reply. In the future we will try to have a Zoom option for big events like this. 

We did manage to record it, but the audio isn't great (and we didn't cover the Q&A)
 

This is pretty interesting.. any outcome you can share? (I'll bug you about this next time I see you in person so you can just tell me then rather than responding, if you'd like)

Good idea to just use the time you fall asleep rather than the sleep stage tracking, which isn't very accurate. I think the most interesting metric is just boring old total sleep time (unfortunately sleep trackers in my experience are really bad at actually capturing sleep quality.. but I suppose if there's a sleep quality score you have found useful that might be interesting to look at also). Something else I've noticed is that by looking at the heart rate you can often get a more accurate idea of when you feel asleep and woke up.