As of 11:30CST, 11/11/14, this cost-benefit analysis has been revised, in order to address concerns raised in the comments. See http://lesswrong.com/r/discussion/lw/l8k/expansion_on_a_previous_costbenefit_analysis_of/ for more on how the cost-benefit analysis was carried out, and on how varying certain parameters affected the determined expected value of receiving a flu shot.

Overview

The purpose of this post is to provide readers of LessWrong with a summary of what the literature has to say about the efficacy and safety of influenza vaccinations, as well as to weigh the costs of receiving yearly flu vaccinations against the benefits which healthy adults gain from vaccination. As illustrated in the "Cost-Benefit Analyses" section of this report, the expected value of receiving flu vaccinations is positive for healthy adults. Therefore, a further motivation for authoring this post is that writing this post may encourage LessWrong readers who have not yet been vaccinated this flu season to receive immediate vaccination.

Introduction and Review of Literature

Several meta-analyses on the efficacy and safety of live-attenuated influenza vaccines, trivalent inactivated influenza vaccines, and tetravalent inactivated influenza vaccines have been published within the last two years (see Coleman et. al, Demicheli et. al, Osterholm et. al). These meta- analyses reached broadly similar conclusions regarding the efficacy of flu vaccines, which groups were most at risk for being infected with influenza, the safety of being vaccinated, and the magnitude of social harm caused yearly by influenza. However, there was disagreement between some articles regarding whether or not vaccination of healthy adults against influenza should be pursued as a public health policy. Specifically, the Demicheli paper (wrongly) found "no evidence for the utilization of vaccination against influenza in healthy adults as a routine public health measure". The issue of whether or not healthy adults should receive flu shots will be examined in the "Cost-Benefit Analyses" section of this report.

While the severity of flu seasons varies greatly year-to-year, an average of 24,000 deaths from the flu occur yearly in the US (NCIRD); approximately 90% of these deaths are in people of at least 65 years of age (NCIRD, CDC Key Facts). For all flu seasons between 1976 and 2007, an average of 2,385 adul...

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