Merkle
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Merkle has not written any posts yet.
There is a helpful web page on the probability that cryonics will work.
There are also some useful facts at the Alcor Scientists' Cryonics FAQ.
The neuroscientist might wish to pay attention to the answer to "Q: Can a brain stop working without losing information?" The referenced article by Mayford, Siegelbaum, and Kandel should be particularly helpful.
Check out Signing up your relatives.
Best of luck, and all my sympathy.
To quote a discussion of long term memory and the specific synaptic changes that take place from Molecular Repair of the Brain:
What, exactly, might these changes be? Very strong statements are possible in simple "model systems". Bailey and Chen, for example, identified several specific changes in synaptic structure that encoded learned memories from sea slugs (Aplysia californica) by direct examination of the changed synapse with an electron microscope[36].
"Using horseradish peroxidase (HRP) to label the presynaptic terminals (varicosities) of sensory neurons and serial reconstruction to analyze synaptic contacts, we compared the fine structure of identified sensory neuron synapses in control and behaviorally modified animals. Our results indicate that learning can modulate long-term synaptic effectiveness by altering the number, size, and vesical complement of synaptic active zones."
A few comments:
1) Sign up for cryonics now. Do not delay because you think "Plastination might be better someday in the future".
2) With chemical preservation, good vascular perfusion is critical. Brain tissue which is not perfused is lost.
3) With cryopreservation, good vascular perfusion results in excellent preservation by vitrification. Brain tissue which is not perfused is still preserved.
4) Most of the costs for neuropreservation are from the up-front logistical and surgical costs. If you want minimal ischemic time and good vascular perfusion for chemical preservation you're still going to have to pay most if not all of those costs.
You'll need to read Molecular Repair of the Brain. Note that it discusses a variety of repair methods, including methods which carry out repairs at sufficiently low temperatures (between 4K and 77K) that there is no risk that "molecular drift" would undo previous work. By making incredibly conservative assumptions about the speed of operations, it is possible to stretch out the time required to repair a system the size of the human brain to three years, but really this time was chosen for psychological reasons. Repairing a person "too quickly" seems to annoy people.
You might also want to read Convergent Assembly. As this is a technical paper which makes no mention of... (read more)
The Alcor FAQ has a question and answer relevant to this discussion:
Q: Why haven't more people signed up for cryonics?
A: People don't sign up for cryonics because: it's not traditional, they're skeptical of anything they haven't seen work, it costs money, they're afraid of what their friends might think, they live in denial of their own death, they don't want to think about the subject, they procrastinate, they don't like life well enough to want more of it, or they are afraid of a future in which they may be alienated from friends and family and a familiar social environment.
Typical Alcor members (if any Alcor member could be called "typical") tend to... (read more)
You might want to read Cryonics, cryptography, and maximum likelihood estimation.
Short summary: if cryptanalytic methods can recover the wiring of World War II rotor machines knowing only some input-output pairs and with only limited information about the actual wiring, then similar algorithms should be able to recover the neuronal "wiring" between different cortical areas when we already have a wealth of information about that wiring plus a good knowledge of acceptable input-output pairs.
How many bytes in human memory? is a very brief article providing estimates of just that. Evidence from human learning experiments suggests that, after using a very good data compression algorithm, human long term declarative memory holds only a few hundred megabytes.
How much of that information is common knowledge, such as knowledge of the English language, memories from media such as books or television, or knowledge of local buildings and streets, is unclear.
Additional information specific to an individual could be gained from email, internet posts, and other personal electronic information and written records, such as diaries; as well as individual genomes, which will soon be ubiquitously available.
The modest information content of human declarative memory might be relevant to some of the discussions on this thread.
General advice: if you can afford it, sign up with Alcor. If you can't, sign up with CI.
If you want more information, I'd recommend the Alcor FAQs.
I should provide some context for my comments on Alcor's previous track record on creating endowments: we had just received a $7M bequest, had placed $3.5M into the Patient Care Trust Fund, and the Board had decided to put the other $3.5M into an Endowment and withdraw only 2% per annum, or about $70,000 per year, for Alcor's operational needs. Some members were feeling quite euphoric and were proposing that we spend some significant amount of the principal on various worthy projects, including reduced dues for... (read more)
Cryonics likely has a probability of success of ~85%, as estimated at Will Cryonics Work?. Lower probability estimates are either unsupported, or supported by arguments with obvious errors. Cryonics deniers sometimes display gross breakdowns in their rational functions, as illustrated by a remarkable quote by Kenneth Storey.
Because deciding against cryonics is a form of suicide, it is selfish for the same reason that suicide is selfish: it causes pain and grief for the survivors, who loved the person who committed cryocide.
Ralph