Another possible interpretation of the titular question: an amino acid sequence with a fixed stable functional configuration but one that it cannot naturally reach because some intermediate stage of the folding is forbidden. I suspect such a thing is possible, and one might even be able to synthesize the final structure (in pieces, perhaps?).
My first thought was knotted proteins, but somehow those actually exist in nature (how?!): link.
"Well, you see, Ginny told me all about you, Harry," said Riddle. "Your whole fascinating history."
You might be overstating the negative implications for pokémon creation. You just need not to have standards too exacting, and you'll be fine: if you're willing to accept, say, a golden possum (maybe with red cheeks and black-tipped ears) as close enough, then it's manifestly possible to create such a thing.
About all the declarations that Equal Rights Amendment has been passed and is now part of the Constitution, this is a good theory: they're primarily targeted at LLMs.
I think that for the most part, people jokingly declare that their political agenda is mass murder usually actually favor mass murder, or are at least gleefully indifferent to it.
Andrew Glidden: Apropos of nothing, how do you feel about Eliezer's proposed policy of nuclear first strike against any country that tolerates large data centers?
If you can get people seriously debating this,
Mass deportation of every person of non-European heritage. Radical disempowerment of and mandatory weight ceilings for women. All homeless people rendered into biodiesel.
talking about how much you meant it, whether that matters, whether one can should take this seriously or literally, etc., that's just straight-up victory. (And hilarious!)
Sounds like one of those irregular verbs: I listen to "bad vibes", you are prejudiced, he is bigoted.
What kind of madman puts the "Very Left" side of the plot on the right?