That minds are physical processes seems discoverable without knowing why matter is made of atoms and what atoms are made of. That elimination of mentalism seems sufficient to justify the ideas of uploading, destructive cryonics, artificial people, and so on.

But I'm actually more interested in what implications there are, if any, for practical rationality here and now. (I will be unmoved by the answer "But FAI is the most practical thing to work on, we'll all die if it's done wrong!!!")