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Vaniver comments on Open thread, Feb. 9 - Feb. 15, 2015 - Less Wrong Discussion
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I recall Eliezer discussing the MetaMed report for him suggesting taking it 5 hours before he wanted to go to sleep, but that was in large part because of his delayed sleep phase disorder. This Reddit thread suggests that 2 hours and 20-30 minutes are both commonly suggested, so agreed that experimentation is likely a good idea.