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It would be the most helpful if done prior to puberty.
I'd worry about cardiovascular side-effects, fat accumulation/redistribution, mental side-effects (something something spatial rotation)... basically, I've studied this on and off since puberty (and not before, because life would be boring if I could do anything right the first time), and concluded that, given my current state of health, castration would probably make more things worse than it improves. Actually, I concluded that circa 2008, and I'm pretty sure I was ever-so-slightly healthier then.
Interesting, might have to look into this some more.
Yeah, the fat distribution thing motivated me not to transition MTF when I was in high school. That and plenty of trannies regret it, most don't pass, and transitioning is more fad than evidence based treatment to gender dysphoria. Plus I reckon in retrospect it was just a bit of transvestic fetishism which isn't good to 'treat' with transitioning.
But yeah, different reasons now.