All of TsviBT's Comments + Replies

Our experience has been that talking to Congressional staffers about a ban or pause on superintelligence research tends to result in blank stares and a rapid end to the meeting. [...] A global moratorium [....] we don’t see anything that we can do to help make that happen.

Ok. Thank you for the info. Would you speculate a bit about what might change this, that other people might be able to do? E.g. what number of call-ins to their offices from constituents, or how many protests, or what industry testimony, or how much campaign funding, etc.

Fair question -- although it would be speculation on my part, since we haven't been actively studying attitudes toward a moratorium. You might do better to ask Pause AI. That said, I would think you'd need something on the scale of the Vietnam War protests to get a blanket unilateral moratorium on advanced AI inside the Overton window -- protests large enough to generate major headlines on most days that continue for months on end. 

If you can get very credible evidence that the UK, the EU, and China would all agree to join such a moratorium, then a sm... (read more)

I mean, I'm not familiar with the whole variety of different ways and reasons that people attack other people as "racist". I'm just saying that only saying true statements is not conclusive evidence that you're not a racist, or that you're not having the effect of supporting racist coalitions. I guess this furthermore implies that it can be justified to attack Bob even if Bob only says true statements, assuming it's sometimes justified to attack people for racist action-stances, apart from any propositional statements they make--but yeah, in that case you'd have to attack Bob for something other than "Bob says false statements", e.g. "Bob implicitly argues for false statements via emphasis" or "Bob has bad action-stances".

Huh? No? Filling in the missing narrative can take a bunch of work, like days or months of study. (What is it even a cope for?)

1tailcalled
It would be a compromise between two factions: people who are hit by the incomplete narrative (whether they are bad actors or not) and centrists who want to maintain authority without getting involved in controversial stuff. Certainly it would be better if the racists weren't selective, and there's a case to be made that centrist authorities should put more work into getting the entire account of what's going on, but that's best achieved by highlighting the need for the opposing side of the story, not by attacking the racists for moving towards a more complete picture.

The term "racist" usually carries the implication or implicature of an attitude that is merely based on an irrational prejudice, not an empirical hypothesis with reference to a significant amount of statistical and other evidence.

It is also possible that Bob is racist in the sense of successfully working to cause unjust ethnic conflict of some kind, but also Bob only says true things. Bob could selectively emphasize some true propositions and deemphasize others. The richer the area, the more you can pick and choose, and paint a more and more outrage-ind... (read more)

It is also possible that Bob is racist in the sense of successfully working to cause unjust ethnic conflict of some kind, but also Bob only says true things. Bob could selectively emphasize some true propositions and deemphasize others.

Sure, though this is equally possible for the opposite: When Alice is shunning or shaming or cancelling people for expressing or defending a taboo hypothesis, without her explicitly arguing that the hypothesis is false or disfavored by the evidence. In fact, this is usually much easier to do than the former, since defendi... (read more)

0tailcalled
This seems like a cope because others could go fill in the missing narrative, so selectively saying stuff shouldn't be a huge issue in general...?
TsviBTΩ5110

See Jessica's comment. Yeah it's primitive recursive assuming that your deductive process is primitive recursive. (Also assuming that your traders are primitive recursive; e.g. if they are polytime as in the paper.) There's probably some other parameters not necessarily set in the implementation described in the paper, e.g. the enumerator of trader-machines, but you can make those primrec.

I wish more people were interested in lexicogenesis as a serious/shared craft. See:

The possible shared Craft of deliberate Lexicogenesis: https://tsvibt.blogspot.com/2023/05/the-possible-shared-craft-of-deliberate.html (lengthy meditation--recommend skipping around; maybe specifically look at https://tsvibt.blogspot.com/2023/05/the-possible-shared-craft-of-deliberate.html#seeds-of-the-shared-craft)

Sidespeak: https://tsvibt.github.io/theory/pages/bl_25_04_25_23_19_30_300996.html

Tiny community: https://lexicogenesis.zulipchat.com/ Maybe it should be a discor... (read more)

Answer by TsviBT40

I think occassionally some lotteries are positive or neutral-ish EV, when the jackpots are really big (like >$1billion)? Not sure. You have to check the taxes and the payment schedules etc.

2ryan_greenblatt
Hard to buy tickets at large scale often I think.

These arguments are so nonsensical that I don't know how to respond to them without further clarification, and so far the people I've talked to about them haven't provided that clarification. "Programming" is not a type of cognitive activity any more than "moving your left hand in some manner" is. You could try writing out the reasoning, trying to avoid enthymemes, and then I could critique it / ask followup questions. Or we could have a conversation that we record and publish.

3romeo
Thanks for linking. I skimmed the early part of this post because you labelled it explicitly as viewpoints. Then I see that you engaged with a bunch of arguments about short timelines, but they are all pretty weak/old ones that I never found very convincing (the only exception is that bio anchors gave me an early ceiling early on around 1e40 FLOP for compute needed to make AGI). Then you got to LLMs and acknowledged: But then gave a bunch of points about the things LLMs are missing and suck at, which I already agree with.  Aside: Have I mischaracterized so far? Please let me know if so. So, do you think you have arguments against the 'benchmarks+gaps argument' for timelines to AI research automation, or why AI research automation won't translate to much algorithmic progress? Or any of the other things that I listed as ones that moved my timelines down: * Fun with +12 OOMs of Compute IMO, a pretty compelling writeup that brought my 'timelines to AGI uncertainty-over-training-compute-FLOP' down a bunch to around 1e35 FLOP * Researching how much compute is scaling. * The benchmarks+gaps argument to partial AI research automation * The takeoff forecast for how partial AI research automation will translate to algorithmic progress. * The recent trend in METR's time horizon data.

I won't give why I think this, but I'll give another reason that should make you more seriously consider this: their sample complexity sucks.

Just think of anything that you've wanted to use a gippity to understand, but it didn't quickly work and you tried to ask it followup questions and it didn't understand what was happening / didn't propagate propositions / didn't clarify / etc.

For its performances, current AI can pick up to 2 of 3 from:

  • Interesting (generates outputs that are novel and useful)
  • Superhuman (outperforms humans)
  • General (reflective of understanding that is genuinely applicable cross-domain)

AlphaFold's outputs are interesting and superhuman, but not general. Likewise other Alphas.

LLM outputs are a mix. There's a large swath of things that it can do superhumanly, e.g. generating sentences really fast or various kinds of search. Search is, we could say, weakly novel in a sense; LLMs are superhumanly fast at doing a ... (read more)

It's straightforward to disprove: they should be able to argue for their views in a way that stands up to scrutiny.

I'd like to see more intellectual scenes that seriously think about AGI and its implications. There are surely holes in our existing frameworks, and it can be hard for people operating within them to spot. Creating new spaces with different sets of shared assumptions seems like it could help.

Absolutely not, no, we need much better discovery mechanisms for niche ideas that only isolated people talk about, so that the correct ideas can be formed.

Hm. I super like the notion and would like to see it implemented well. The very first example was bad enough to make me lose interest: https://russellconjugations.com/conj/1eaace137d74861f123219595a275f82 (Text from https://www.thenewatlantis.com/publications/the-anti-theology-of-the-body)

So I tried the same thing but with more surrounding text... and it was much better!... though not actually for the subset I'd already tried above. https://russellconjugations.com/conj/3a749159e066ebc4119a3871721f24fc

1Sting
I tried Claude 3.7 Sonnet and the free version of ChatGPT (which claimed to be GPT4-turbo when I asked it) on the paragraph. Claude garbled a lot of the sentences, especially towards the end. ChatGPT does better, with the last sentence probably being the best one: "And men who are ⁠impatient of frailty and contemptuous of weakness are, at the end of the day, ⁠inevitably evil."  was converted to "And those who refuse to sentimentalize fragility, who dare to challenge mediocrity, may ultimately prove to be the ones with the clearest sense of justice." Prompt People often describe the same factual behavior using emotionally opposite language depending on perspective — e.g. I am firm, you are obstinate, he is pigheaded. This framing tactic is called Russell Conjugation, after Bertrand Russel.  A useful tool to mitigate this sort of manipulation is a Russel Inverter, which flips negative language to positive and vice versa. For instance "The senator ⁠remained pigheaded despite ⁠consensus" fed through the Russel Inverter, becomes "The senator held firm despite groupthink". Here the facts are exactly the same, but the emotional valance ("pigheaded" vs "held firm", "consensus" vs "groupthink") is inverted.  Please Russel invert the following text: Original quote ⁠Transhumanism, as a moral philosophy, is so ⁠risibly fabulous in its prognostications, and so ⁠unrelated to anything that genomic research yet promises, that it can scarcely be regarded as anything more than a ⁠pathetic dream; but the ⁠metaphysical principles it presumes regarding the nature of the human are anything but ⁠eccentric. Joseph Fletcher was a man with a ⁠manifestly brutal mind, ⁠desperately anxious to believe himself superior to the common run of men, one who apparently received some sort of ⁠crypto-erotic thrill from his ⁠cruel fantasies of creating a slave race, and of ⁠literally branding others as his genetic inferiors, and of ⁠exercising power over the minds and bodies of the low-born. And

A longer sentence is produced by, and is asking the reader to be, putting more things together in the same [momentary working memory context]. Has advantages and disadvantages, but is not the same.

Yes, and this also applies to your version! For difficult or subtle thoughts, short sentences have to come strictly after the long sentences. If you're having enough such thoughts, it doesn't make sense to restrict long sentences out of communication channels; how else are you supposed to have the thoughts?

On second/third thought, I think you're making a good point, though also I think you're missing a different important point. And I'm not sure what the right answers are. Thanks for your engagement... If you'd be interested in thinking through this stuff in a more exploratory way on a recorded call to be maybe published, hopefully I'll be set up for that in a week or two, LMK.

On the "self-governing" model, it might be that the blind community would want to disallow propagating blindness, while the deaf community would not disallow it:

https://pmc.ncbi.nlm.nih.gov/articles/PMC4059844/

Judy: And how’s… I mean, I know we’re talking about the blind community now, but in a DEAF (person’s own emphasis) community, some deaf couples are actually disappointed when they have an able bodied… child.

William: I believe that’s right.

Paul: I think the majority are.

Judy: Yes. Because then …

Margaret: Do they?

Judy: Oh, yes! It’s well known down at ... (read more)

1River
Interesting. I think I'd take the same position about deafness that I would about blindness. But I also find it a very understandable and natural human emotion for a person who is damaged to want to surround themselves with others who are damaged in the same way, and to be disappointed when their child isn't. That seems entirely compatible with not being willing to intentionally damage a child.

I am trying to point out to you that almost everyone in our society has the view that blinding children is evil.

Our society also has the view that people should be allowed to reproduce freely, even if they'll pass some condition on to their child.

5River
I agree. We aren't talking about whether blind people should be allowed to reproduce freely, even when doing so has the foreseeable consequence that the child will be blind. We are talking about whether they should be allowed to do an action, beyond the simple act of reproducing, to cause their child to be blind.

you are influencing them at the stage of being an embryo

I'm mainly talking about engineering that happens before the embryo stage.

That's just not a morally coherent distinction, nor is it one the law makes

Of course it's one the law makes. IIUC it's not even illegal for a pregnant woman to drink alcohol.

If you want to start a campaign to legalize the blinding of children, well, we have a free speech clause, you are entitled to do that. Have you considered maybe doing it separately from the genetic engineering thing?

I can't tell if you're strawman... (read more)

1River
  I'm not sure if you're correcting my technical vocabulary or trying to counter my argument. Either is welcome. While I am excited about this technology and its potential to improve the human species, I'm obviously not a biologist myself.   Nor is it illegal to use harsh language with your children. "Abuse" is a word that exists to pick out a sufficiently extreme degree of wrong that most people would not do it, and intervention is warranted against those who do. Most states do regulate drug use by pregnant women somehow, see https://projects.propublica.org/graphics/maternity-drug-policies-by-state. And the controversy around this is based mostly on the idea that taking a medical approach rather than a criminalization approach results in better outcomes for the children, which is an argument that just doesn't translate over to the genetic engineering context.

Whether you do it by genetic engineering or surgically or through some other means is entirely beside the point. Genetic engineering isn't special.

I'm not especially distinguishing the methods, I'm mainly distinguishing whether it's being done to a living person. See my comment upthread https://www.lesswrong.com/posts/rxcGvPrQsqoCHndwG/the-principle-of-genomic-liberty?commentId=qnafba5dx6gwoFX4a

We get genetic engineering by showing people that it is just another technology, and we can use it to do good and not evil, applying the same notions of good a

... (read more)
1River
Genetic engineering is a thing you do to a living person. If a person is going to go on to live a life, they don't somehow become less a person because you are influencing them at the stage of being an embryo in a lab. That's just not a morally coherent distinction, nor is it one the law makes. Nothing in my position is hinging on my personal moral views. I am trying to point out to you that almost everyone in our society has the view that blinding children is evil. And our society already has laws against child abuse which would prohibit blinding children by genetic engineering. Virtually nobody wants to change that, and any politician who tried to change those laws would be throwing away their career. It's not about me. I'm pointing out where society is. If you want to start a campaign to legalize the blinding of children, well, we have a free speech clause, you are entitled to do that. Have you considered maybe doing it separately from the genetic engineering thing? The technology to blind children already exists. If you really think it is worth running an experiment on a generation of children, why don't you try to legalize doing it with the technology we already have and go from there? If, somehow, you succeed in changing the law, you'd even get your experiment quicker. How would a person who has been blind their whole life know? They haven't had the experience of sight to compare to. They seem like the people in the worst position to make the comparison. People who have the experience of seeing are necessarily the ones who can judge whether that is a good thing or not. When it comes to any child, it is up to the existing law of child abuse. That trumps whatever an individual parent may think. Lets not get into autistic people. Autism comes in more varieties than blindness, and some of those varieties I think are much more debatable. For blindness, do you have any idea what that fraction is?

i think i'm in the wrong universe, can someone at tech support reboot the servers or something? it's not reasonable for you to screw up something as simple as putting paying customers in the right simulation . and then you're like "here's some picolightcones". if you actually cared it would be micro or at least nano

Yeah, cognitive diversity is one of those aspects that could be subject to some collapse. Anomaly et al.[1] discuss this, though ultimately suggest regulatory parsimony, which I'd take even further and enshrine as a right to genomic liberty.

I feel only sort-of worried about this, though. There's a few reasons (note: this is a biased list where I only list reasons I'm less worried; a better treatment would make the opposite case too, think about bad outcomes, investigate determinative facts, and then make judgements, etc.):

  • Although I want the tech to be s
... (read more)

So I guess one direction this line of thinking could go is how we can get the society-level benefits of a cognitive diversity of minds without necessarily having cognitively-uneven kids grow up in pain.

Absolutely, yeah. A sort of drop-dead basic thing, which I suppose is hard to implement for some reason, is just not putting so much pressure on kids--or more precisely, not acting as though everything ought to be easy for every kid. Better would be skill at teaching individual kids by paying attention to the individual's shape of cognition. That's diffic... (read more)

2Mo Putera
I don't know either, but I think of Tracing Woodgrains' Center for Educational Progress and the growing Discord community around it as a step in this direction.

With or without ASI, certainly morphological autonomy is more or less a universal good.

IDK what to say... I guess I'm glad you're not in charge? @JuliaHP I've updated a little bit that AGI aligned to one person would be bad in practice lol. 

3Sting
Haha, well, at least I changed your mind about something. 
1Sting
If we had ASI we could just let the children choose their own genes once they grow up. Problem solved. 

I am the Law, the Night Watchman State, the protector of innocents who cannot protect themselves. Your children cannot prevent you from editing their genes in a way that harms them, but the law can and should.

I do think this is in interesting and important consideration here; possibly the crux is quite simply trust in the state, but maybe that's not a crux for me, not sure.

if we had a highly competent government that could be trusted to reasonably interpret the rules,

Yeah, if this is the sort of thing you're imagining, we're just making a big different background assumption here.

I don't think we have enough evidence to determine that removing the emotion of fear is "unambiguous net harm", but it would be prohibited under your "no removing a core aspect of humanity" exception.

Yeah, on a methodological level, you're trying to do a naive straightforward utilitarian consequentialist thing, maybe? And I'm like, this isn't ... (read more)

3Sting
You are welcome. It has been fun inventing the PERFECT government policy and giving so many 100% CORRECT takes.  (Also remember, even the best possible policy cannot survive execution by an incompetent and untrustworthy government. My policies are only good if they are actually followed.)
1Sting
The question is if it really is their opinion. People often say things they don't believe as cope or as tribal signalling. If a non-trivial number of people who perceive themselves and their ingroup as intelligent, were to say they anti-value intelligence, that would update me.   Under my system we can ask people with below-average IQ whether they are happy to be below-average intelligence. If they are unhappy, outlaw gene editing for low intelligence. If they are happy, then either allow it, or decide to overrule them.  You want to be careful about overruling people. But intelligence is uniquely tricky because, if it is too low, people are not competent to decide what they want. Plus, people with low IQs have bad objective measures (e.g., significantly lower life expectancy). 

I'm genuinely unsure whether or not they would. Would be interesting to know.

One example, from "ASAN Statement on Genetic Research and Autism" https://autisticadvocacy.org/wp-content/uploads/2022/03/genetic-statement-recommendations.pdf :

ASAN opposes germline gene editing in all cases. Germline gene editing is editing a person’s genes that they pass down to their children. We do not think scientists should be able to make gene edits that can be passed down to a person’s children. The practice could prevent future generations of people with any gene-relat

... (read more)

Yes, blind people are the experts here. If 95% of blind people wish they weren't blind, then (unless there is good reason to believe that a specific child will be in the 5%) gene editing for blindness should be illegal.

This is absolutely not what I'm suggesting. I'm suggesting (something in the genre of) the possibility of having that if 95% of blind people decide that gene editing for blindness should be illegal, then gene editing for blindness should be illegal. It's their autonomy that's at issue here.

1Sting
Fair point, I glossed over the differences there. Although in practice I think very few blind people who wish they could see, would be in favor of gene editing for blindness being legal. 

Oh, I guess, why haven't I said this already: If you would, consider some trait that:

  1. you have, and
  2. is a mixed blessing, and
  3. that many / most people would consider a detriment, and
  4. that is uncommon.

I'l go first:

In my case, besides being Jewish lol, I'm maybe a little schizoid, meaning I have trouble forming connections / I tend to not maintain friendships / I tend to keep people at a distance, in a systematic / intentional way, somewhat to my detriment. (If this is right, it's sort of mild or doesn't fully fit the wiki page, but still.) So let's say I'm... (read more)

1Sting
I do not have autism/ADHD/bipolar/dyslexia/dysphoria or a non-heterosexual orientation. If I woke up tomorrow with one of those, I would very badly want it reverted.  However, it seems obvious to me that if being a little schizoid made you a free thinker, able to see things most others can't see, able to pursue good things that most others won't pursue, then it does not count as "unambiguous net harm" and the government should have no say in whether you can pass it on. That's not even close to the line of what the government should be allowed to prohibit. 

I think "edited children will wish the edits had not been made" should be added to the list of exceptions.

So to be clear, your proposal is for people who aren't blind to decide what hypothetical future blind children will think of their parents's decisions, and that judgement should override the judgement of the blind parents themselves? This seems wild to me.

... Ok possibly I could see some sort of scheme where all the blind people get to decide whether to regulate genomic choice to make blind children? Haven't thought about this, but it seems pretty m... (read more)

1Sting
Yes, blind people are the experts here. If 95% of blind people wish they weren't blind, then (unless there is good reason to believe that a specific child will be in the 5%) gene editing for blindness should be illegal.  (Although we might overrule blind people if they claimed to be happy but had bad objective measures, like high rates of depression and suicide.)

I would prefer a "do no harm" principle

I'm still unclear how much we're talking past each other. In this part, are you suggesting this as law enforced by the state? Note that this is NOT the same as

For instance, humans near-universally value intelligence, happiness, and health. If an intervention decreases these, without corresponding benefits to other things humans value, then the intervention is unambiguously bad.

because you could have an intervention that does result in less happiness on average, but also has some other real benefit; but isn't th... (read more)

The topic has drifted from my initial point, which is that there exist some unambiguous "good" directions for genomes to go. After reading your proposed policy it looks like you concede this point, since you are happy to ban gene editing that causes severe mental disability, major depression, etc. Therefore, you seem to agree that going from "chronic severe depression" to "typical happiness set point" is an unambiguous good change. (Correct me if I am wrong here.)

I haven't thought through the policy questions at any great length. Actually, I made up all my... (read more)

To you, "the principle of genomic liberty" is the best policy

No! Happy to hear alternatives. But I do think it's better than "prospectively ban genomic choices for traits that our cost-benefit analysis said are bad". I think that's genuinely unjust, partly because you shouldn't be the judge of whether another person's way of being should exist.

I think the future opinion of the gene-edited children is important. Suppose 99% of genetically deafened children are happy about being deaf as adults, but only 8% of genetically blinded children are happy about

... (read more)
1Sting
By "best policy" I meant "current most preferred policy".  "prospectively ban genomic choices for traits that our cost-benefit analysis said are bad" is not my position. My position is "ban genomic edits that cause traits that all reasonable cost-benefit analysis agree are bad", where "reasonable" is defined in terms of near-universal human values. I say more about this here. I skimmed the article earlier, and read through it more carefully now. I think "edited children will wish the edits had not been made" should be added to the list of exceptions. Also, if we can already predict with high confidence which changes will be regretted, why wait until the next generation to ban them?

I would be happy to accept "the principle of genomic liberty" over status-quo, since it is reasonably likely that lawmakers will create far worse laws than that.

Ok. Then I'm not sure we even disagree, though we might. If we do, it would be about "ideal policies". My post about Thurston (which was about as successful as I expected at making the point, which is to say, medium at best) is trying to strike some doubt in your heart about the ideal policy, because you don't know what it's like to be other people and you don't know what sort of weird ways they... (read more)

1Sting
I think our disagreement over ideal policy spills over into practice as well. To you, "the principle of genomic liberty" is the best policy, while to me it is one of many policies that is less bad than status quo.  I think the future opinion of the gene-edited children is important. Suppose 99% of genetically deafened children are happy about being deaf as adults, but only 8% of genetically blinded children are happy about being blind. In that case, I would probably make the former legal and the latter illegal.  I did read the linked comment, and I agree that gouging a child's eyes out is different. But I don't see a difference between "immediately after birth, have the doctor feed your child a chemical that painlessly causes blindness" and gene editing. To me, both seem about the same level of soul-damaging. Many of the linked arguments don't apply at all to the new scenario, and I didn't find any of the rest remotely convincing, but I don't feel like taking the time to create a point-by-point response. 

So it seems your argument is "even if all reasonable cost-benefit analyses agree, things are still ambiguous". Is that really your position?

Yeah. Well, we're being vague about "reasonable".

If by "reasonable" you mean "in practice, no one could, given a whole month of discussion, argue me into thinking otherwise", then I think it's still ambiguous even if all reasonable CBAs agree.

If by "reasonable" you mean "anyone of sound mind doing a CBA would come to this conclusion", then no, it wouldn't be ambiguous. But I also wouldn't say that it should be prote... (read more)

3Sting
By "reasonable" I meant "is consistent with near-universal human values". For instance, humans near-universally value intelligence, happiness, and health. If an intervention decreases these, without corresponding benefits to other things humans value, then the intervention is unambiguously bad. Instead of "the principle of genomic liberty", I would prefer a "do no harm" principle. If you don't want to do gene editing, that's fine. If you do gene editing, you cannot make edits that, on average, your children will be unhappy about. Take the following cases: 1. Parents want to genetically modify their child from an IQ of 130 to an IQ of 80. 2. Parents want to genetically modify their child to be blind.[1] 3. Parents want to genetically modify their child to have persistent mild depression.[2] People generally prefer to be intelligent and happy and healthy. Most people who have low intelligence or are blind or depressed wish things were otherwise. Therefore, such edits would be illegal.  (There may be some cases where "children are happy about the changes on net after the fact" is not restrictive enough. For instance, suppose a cult genetically engineers its children to be extremely religious and extremely obedient, and then tells them that disobedience will result in eternal torment in the afterlife. These children will be very happy that they were edited to be obedient.) A concrete example of where I disagree with the "principle of genomic liberty":  Down syndrome removes ~50 IQ points. The principle of genomic liberty would give a Down syndrome parent with an IQ of 90 the right to give a 140 IQ embryo Down syndrome, reducing the embryo's IQ to 90 (this is allowed because 90 IQ is not sufficient to render someone non compos mentis). 1. ^ Explicitly allowed by the principle of genomic liberty if one of the parents is blind. 2. ^ Major depression is explicitly not protected by the principle of genomic liberty.

Down syndrome, or Tay-Sachs disease

I'd have to learn more, but many forms of these conditions (and therefore the condition simpliciter, prospectively) would probably prevent the child from expressing their state of wellbeing, through death or unsound mind. Therefore these would fall under the recognized permanent silencing exception to the principle of genomic liberty, and wouldn't be protected forms of propagation. Further, my impression is that living to adulthood with Tay-Sachs is quite rare; most people with Tay-Sachs variants wouldn't be passing on... (read more)

2Sting
It sounds like your goal is to build a political coalition, and I am talking about my ideal policies. I would be happy to accept "the principle of genomic liberty" over status-quo, since it is reasonably likely that lawmakers will create far worse laws than that.  Is your position that at least one parent must be blind/deaf/dwarf in order to edit the child to be the same? If so, that is definitely an improvement over what I thought your position was.  I'm not sure what the difference is supposed to be between "blinding your children via editing their genes as an embryo" and "painlessly blinding your children with a chemical immediately after birth". The outcome is exactly the same. 

But really my objection is why the fuck would you think causality works like that?

Not sure why you're saying "causality" here, but I'll try to answer: I'm trying to construct an agreement between several parties. If the agreement is bad, then it doesn't and shouldn't go through, and we don't get germline engineering (or get a clumsy, rich-person-only version, or something).

Many parties have worries that route through game-theory-ish things like slippery slopes, e.g. around eugenics. If the agreement involves a bunch of groups having their reproduction m... (read more)

1River
I think the frames in which you are looking at this are just completely wrong. We aren't really talking about "decisions about an individuals' reproduction". We are talking about how a parent can treat their child. This is something that is already highly regulated by the state, CPS is a thing, and it is good that it is a thing. There may be debates to be had about whether CPS has gone too far on certain issues, but there is a core sort of evil that CPS exists to address, and that it is good for the state to address. And blinding your child is a very core paradigmatic example of that sort of evil. Whether you do it by genetic engineering or surgically or through some other means is entirely beside the point. Genetic engineering isn't special. It is just another technology. To take something that is obviously wrong and evil when done by other means, that everyone will agree the state should prevent when done by other means, and say that the state should allow it when done by genetic engineering, that strikes me as a major political threat to genetic engineering. We don't get genetic engineering to happen by creating special rules for it that permit monstrosities forbidden by any other means. We get genetic engineering by showing people that it is just another technology, and we can use it to do good and not evil, applying the same notions of good and evil that we would anywhere else. If a blind parent asked a surgeon to sever the optic nerve of of their newborn baby, and the surgeon did it, both the parents and the surgeon would go to jail for child abuse. Any normal person can see that a genetic engineer should be subject to the same ethical and legal constraints there as the surgeon. Arguing otherwise will endanger your purported goal of promoting this technology.   This notion of "erasing a type of person" also seems like exactly the wrong frame for this. When we cured smallpox, did we erase the type of person called "smallpox survivor"? When we feed a hungry pe

Why? A human body without a meaningful nervous system inside of it isn't a morally relevant entity, and it could be used to save people who are morally relevant.

Isn't that what I just said? Not sure whether or not we disagree. I'm saying that if you just stunt the growth of the prefrontal cortex, maybe you can argue that this makes the person much less conscious or something, but that's not remotely enough for this to not be abhorrent with a nonnegligible probability; but if you prevent almost all of the CNS from growing in the first place, maybe this i... (read more)

2River
  I feel like you've just asked me if it is worth committing a few murders now to being about a future world where there are far fewer murders. Like, if I really thought causality worked that way, maybe, at that point we are getting into hard consequentialism versus strong conventional ethical norms and that is a murky place to be but maybe. But really my objection is why the fuck would you think causality works like that? People who want to blind their own children now are not going to be useful allies in eliminating blindness later! Of course not. As I said, most blind people's lives are worth living, and we don't yet have the technology in place to allow such people to procreate without passing on their blindness. Once we do, then some legal intervention probably is warranted, though I haven't given much thought to its shape and its shape might depend on the particulars of the technology.

I predict any reasonable cost-benefit analysis will find that intelligence and health and high happiness-set-point are good, and blindness and dwarfism are bad.

This is irrelevant to what I'm trying to communicate. I'm saying that you should doubt your valuations of other people's ways of being--NOT so much that you don't make choices for your own children based on your judgements about what would be good for them and for the world, or advocate for others to do similarly, but YES so much that you hesitate quite a lot (like years, or "I'd have to deeply i... (read more)

3Sting
I don't understand your position. My position is: 1. Higher intelligence and health and happiness-set-point are unambiguous good directions for the genome to go. Blindness and dwarfism are unambiguous bad directions for the genome to go.  2. Therefore, the statement "there are no unambiguous good directions for genomes to go" is false.  3. Since the statment is false, it is a bad argument. Which step of this chain, specifically, do you disagree with? It sounds like you disagree with the first point. But then you say the fact that "any reasonable cost-benefit analysis will find that intelligence and health and high happiness-set-point are good" is irrelevant to your argument. So it seems your argument is "even if all reasonable cost-benefit analyses agree, things are still ambiguous". Is that really your position?
8Sting
Government intervention comes with risks, but if I had an iron-clad guarantee against slippery-slope dynamics I would not want it to be legal to genetically engineer a healthy embryo to be have Down syndrome, or Tay-Sachs disease, or be blind. It is already illegal to blind your children after they are born, and this is a good thing imo. I don't think parents should be required to use genetic engineering to increase their children's intelligence, health, and happiness set point. However, I don't think parents should be allowed to harm their children along these axes. (Just like it is already illegal to feed your children lead in order to decrease their intelligence.) I am quite certain that, even after thinking about it for years, I would still be against feeding children lead or genetically altering them to be less intelligent. That being the case, I don't think that this topic would be a good use of several years of thinking time. For what it's worth, I agree that the state should be involved as little as is reasonable. But if it would be illegal to do something through non-gene-editing means, it should also be illegal to do through gene editing. "You cannot blind your children, unless you do it through gene editing, then it's totally fine" does not seem to me like a reasonable public policy. 

Excellent! Thank you for researching and writing up this article.

A few notes, from my discussion with Morpheus:

  • A single UPD has 1/23rd incorrect imprinting, so to speak. It's plausible that a fairly benign UPD has some small effect that's barely noticeable--but then if you have a zygote with many incorrect imprints, say 1/2 or 1/4 incorrect imprinting, that these effects would add up a lot and be quite detrimental, producing an epigenomic near-miss.
  • Indeed, we might sort of suspect this by default. On the model that says "Paternal/Maternal imprints make
... (read more)

Thanks.

If one is going to create an organ donor, removing consciousness and self-awareness seems essential.

If you can't do it without removing almost all of the nervous system, I think it would be bad!

These are all worth doing if we can figure out how.

Possibly. I think all your examples are quite alarming in part because they remove a core aspect. Possibly we could rightly decide to do some of them, but that would require much more knowledge and deliberation. More to the point: I'm not making a strong statement like "prohibit these uses". I'm a wea... (read more)

5River
Why? A human body without a meaningful nervous system inside of it isn't a morally relevant entity, and it could be used to save people who are morally relevant. I'll continue with your free speech analogy to illustrate what I think is the problem here. It is true, as a matter of constitutional law, that when the Supreme Court carves out an exception to the Free Speech Clause, that does not automatically make that speech a crime. But I think that is more a matter of how our system is structured - the Supreme Court gets to interpret the constitution, but does not get to create crimes. Legislatures get to create crimes, and so for a sort of speech to become a crime, even after the Supreme Court creates an exception for it, still requires action from a legislature. But when I think about particular exceptions, they all fall into one of two categories. Either I think the speech is really bad and should be criminalized (true threats, incitement of imminent lawless action) or I think the court was mistaken to create the exception (obscenity, fighting words). There isn't an in between category where I think a type of speech is rightly an exception to the Free Speech Clause, but it's ok for a legislature not to ban it. Similarly, if we think genomic liberty is important enough to be called a "liberty", and we also think that some particular use of genetic technology is bad enough to warrant an exception to that liberty, then I think that use also has to be bad enough that it should be banned. I don't see a coherent middle ground. I don't see why this wouldn't be the case with blinding a child through germ line engineering. If I imagine myself growing up blind, and then I learned that my parents had engineered my genome that way, I would absolutely see that as a boundary violation and a betrayal of bedrock civility. If anything I would view it as worse than gouging my eyes out, because it is necessarily cool and calculated and premeditated in a way that gouging out of eyes

(BTW I think you asking about entanglement sequencing caused me to a few days later realize that for chromosome selection, you can do at least index sensing by taking 1 chromosome randomly from a cell, and then sequencing/staining the remaining 22 (or 45), and seeing which index is missing. So thanks :) )

IMO a not yet fully understood but important aspect of this situation is that what someone writes is in part testimony--they're asserting something that others may or may not be able to verify themselves easy, or even at all. This is how communication usually works, and it has goods (you get independent information) and bads (people can lie/distort/troll/mislead). If a person is posting AIgen stuff, it's much less so testimony from that person. It's more correlated with other stuff that's already in the water, and it's not revealing as much about the perso... (read more)

If there are some skilled/smart/motivated/curious ML people seeing this, who want to work on something really cool and/or that could massively help the world, I hope you'll consider reaching out to Tabula.

https://www.lesswrong.com/posts/SsLkxCxmkbBudLHQr/

I chatted with Michael and Ammon. This made me somewhat more hopeful about this effort, because their plan wasn't on the less-sensible end of what I uncertainly imagined from the post (e.g. they're not going to just train a big very-nonlinear map from genomes to phenotypes, which by default would make the data problem worse not better).

I have lots of (somewhat layman) question marks about the plan, but it seems exciting/worth trying. I hope that if there are some skilled/smart/motivated/curious ML people seeing this, who want to work on something really co... (read more)

2tgb
I'm not as concerned about your points because there are a number of projects already doing something similar and (if you believe them) succeeding at it. Here's a paper comparing some of them: https://www.biorxiv.org/content/10.1101/2025.02.11.637758v2.full
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