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gwern comments on Case study: Melatonin - Less Wrong

21 Post author: gwern 07 January 2010 06:24PM

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Comment author: gwern 12 April 2010 03:12:27PM *  6 points [-]

Since I wrote this post, the following comments have come in. If I missed any, please PM or reply with links. The following entries are compiled from LessWrong, #lesswrong, gwern.net, Reddit, or Google+, generally in relation to this melatonin essay; I classify as using/positive anyone who is using melatonin or will likely use melatonin in the future for any reason (eg. daily use counts, but so does using it for jetlag), and as negative/null anyone who is no longer using it for any reason (eg. found a better way to induce vivid dreams, or found it made them sleep better but this interfered with their diabetes-related medical devices).

Using/positive:

Not using/mixed/negative:

Unknown:

  • AdeleneDawner
  • CasioTheSane
  • Curiouskid
  • Cyan
  • Ralith
  • SoullessAutomaton
  • handoflixue
  • kevin
  • nazgulnarsil
  • shokwave
  • philh
Comment author: Eliezer_Yudkowsky 12 June 2012 01:02:12AM 7 points [-]

I am microdosing, 300mcg plain + 300mcg time-release, both from LEF. Currently trying doubling the time-release dosage to see if that works better. More than 400mcg up-front did not work well. In general, people trying melatonin are advised to try microdoses.

Comment author: gwern 12 June 2012 01:21:26AM 4 points [-]

In general, people trying melatonin are advised to try microdoses.

That's definitely something I noticed in the anecdotes: people with positive experiences seem to mention switching to <1mg doses, while people with negative experiences tend to mention >1mg doses and not experimenting.

I'm going to strengthen the language in my melatonin essay dealing with dosage, and add some reminders to myself to do more blind experiments with differing doses when I run out of my current melatonin pill mixes.

Comment author: John_Maxwell_IV 28 July 2013 10:34:49PM 1 point [-]

I'm going to strengthen the language in my melatonin essay dealing with dosage, and add some reminders to myself to do more blind experiments with differing doses when I run out of my current melatonin pill mixes.

Any updates on this?

Comment author: gwern 29 July 2013 08:28:26PM 1 point [-]

Not yet. My five-fold sleep experiment was originally supposed to be long done by now, but I put the lithium part on hold to run another long experiment, and so it hasn't finished yet. Hopefully I'll be able to start by 2014.