Welcome! Commenting on the Sequences isn't against any rules. You stand a chance of getting responses from who watch the Recent Comments. However, in Discussion you'll see [SEQ RERUN] posts (which are bringing up old posts in the Sequences in chronological order) that encourage comments on the rerun, not the original. If you happen to be reading a post that's been recently re-run, you might get a better response in the rerun thread.