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But maybe soon we'll have better data: https://www.sciencemag.org/news/2020/03/who-launches-global-megatrial-four-most-promising-coronavirus-treatments

I think official science should be pretty good on this one unless we find some mismatching incentives like in Inadequate Equilibria

See in context

57 March Coronavirus Open Thread

by Elizabeth

8th Mar 2020

1 min read

378

57

This thread was created on 3/8/2020, or approximately one million years ago in virus time. It’s getting pretty bloated now, and a lot of things that were high value at the time have been eclipsed by events, making karma not a very useful sorting tool. So I’m declaring this thread finished, and asking everyone to move over to the April Coronavirus Open Thread.

Interested in what happened in this thread? Here’s the timeless or not-yet-eclipsed highlights:

Scott Alexander comes up with Hammer and Dance 6 days before Tomas Pueyo
Spiracular on why SARS-Cov-2 is unlikely to be lab-created.
Two documents collating estimates of basic epidemiological parameters, in response to this thread
Discussion on whether the tuberculosis vaccine provides protection against COVID-19.
Suggestive evidence that COVID-19 removes sense of taste and smell.
Could copper tape be net harmful?

Covid-19Open Threads

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71Coronavirus as a test-run for X-risks

37Tagging (Click Gear Icon to filter Coronavirus content)

37LW Team Updates: Pandemic Edition (March 2020)

34April Coronavirus Open Thread

31LW Coronavirus Agenda Update 3/31

March Coronavirus Open Thread

7Alexander Gietelink Oldenziel

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[-]Scott Alexander5y460

China is following a strategy of shutting down everything and getting R0 as low as possible. This works well in the short term, but they either have to keep everything shut down forever, or risk the whole thing starting over again.

UK is following a strategy of shutting down only the highest-risk people, and letting the infection burn itself out. It's a permanent solution, but it's going to be really awful for a while as the hospitals overload and many people die from lack of hospital care.

What about a strategy in between these two? Shut everything down, then gradually unshut down a little bit at a time. Your goal is to "surf" the border of the number of cases your medical system can handle at any given time (maybe this would mean an R0 of 1?) Any more cases, and you tighten quarantine; any fewer cases, and you relax it. If you're really organized, you can say things like "This is the month for people with last names A - F to go out and get the coronavirus". That way you never get extra mortality from the medical system being overloaded, but you do eventually get herd immunity and the ability to return to normalcy.

This would be sacrificing a certai... (read more)

[-]AlexSchell5y170

If you first do lockdowns to get new cases to ~0 and then relax, optimistically you will get localized epidemics that you can contain with widespread testing, contact tracing, and distancing if needed. Cost of testing & tracing and having to do occasional local/regional lockdowns could end up being manageable until treatment/vaccine arrives.

My main reason for optimism is Korea's and China's success containing a large outbreak. We will be expecting the secondary epidemics and reacting quickly, so they will be small when detected, so should be much easier to contain than the first surprise outbreak.

We'll get data on this in the coming months as China loosens restrictions. There is option value in containing asap and first trying things other than deliberate infections.

1Jackson L5y

Linking the The Imperial College paper here (which a lot of people have referenced lately) that addresses these two approaches: (a) mitigation, which focuses on slowing but not necessarily stopping epidemic spread –reducing peak healthcare demand while protecting those most at risk of severe disease from infection, and (b) suppression, which aims to reverse epidemic growth, reducing case numbers to low levels and maintaining that situation indefinitely. (https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-COVID19-NPI-modelling-16-03-2020.pdf) The biggest issue with the suppression strategy is the time required for the lockdown - until R reaches low enough levels that eliminate human-to-human transmission, or until a vaccine is available. Estimated 12-18 months with a r0 of 2.4. In fact the more successful a strategy is at temporary suppression (China), the larger the later epidemic if the lockdown is lifted prematurely - due to lesser build-up of herd immunity (Figure 3, "post-September 2020"). Mitigation: "In the most effective mitigation strategy examined, which leads to a single, relatively short epidemic, the surge limits for both general ward and ICU beds would be exceeded by at least 8-fold under the more optimistic scenario for critical care requirements that we examined. In addition, even if all patients were able to be treated, we predict there would still be in the order of 250,000 deaths in GB, and 1.1-1.2 million in the US."

1AlexSchell5y

Their paper is not relevant as they do not analyze testing & contact tracing AT ALL, only mentioning it briefly in the Discussion section. I think everyone who thinks the strategy I describe might be feasible (which now seems to be most informed participants in the discussion on here & rationalist Twitter) more or less agrees with the Ferguson analysis if you assume you can't do testing & tracing & isolation or they won't work.

5Jackson L5y

Yes you are correct, succinctly addressed here " They ignore standard Contact Tracing [2] allowing isolation of infected prior to symptoms. They also ignore door-to-door monitoring to identify cases with symptoms [3]. Their conclusions that there will be resurgent outbreaks are wrong. After a few weeks of lockdown almost all infectious people are identified and their contacts are isolated prior to symptoms and cannot infect others [4]. " https://necsi.edu/review-of-ferguson-et-al-impact-of-non-pharmaceutical-interventions

[-]gwillen5y140

I've spent some time thinking about endgames here. (Not that I feel like I've come to any conclusions. I wish I knew what e.g. the WHO thought the endgame was.) The biggest problem I see with this idea is the lag between input and output -- when you change your quarantine measures, you can't observe the result for at least the 5-7 days it takes the newly infected to get symptoms, and longer if you want to get a lot of confidence in your measurement, over the noise inherent in the system.

Control systems with high lag like this are incredibly difficult to work with. Especially in the presence of exponential growth like this system has -- if you accidentally let R get a bit too high, it will be a week or two before you notice, and in that time you will have seeded a ton of cases that you will have to track down and deal with.

I think the most hopeful endgame here, near-mid-term, is that we find a combination of antivirals with high effectiveness against COVID-19, which reduces the rate of severe pneumonia dramatically. At that point our hardest constraint, ventilators, will get relaxed. Beds are a lot easier to deal with a shortage of.

Mid-long-term, of course, we're all hoping for a va

... (read more)

2Roko5y

This is why you need to have borders on multiple scales and cancellation of large events. If one case slips through, in a week or two they will infect a handful of new people. If you have set up a system of regional and national borders, as well as cancelled large events, you will find out about this trace the contacts and temporarily increase the strength of the lockdown in only that region. This strategy nearly worked in South Korea, but then patient 31 was a superspreader: https://graphics.reuters.com/CHINA-HEALTH-SOUTHKOREA-CLUSTERS/0100B5G33SB/index.html

7Alexander Gietelink Oldenziel5y

Just like to chime in to say that this (=' flattening the curve/ herd immunity') fundamentally doesn't work, and you don't need to have a PhD in epidemiology from Imperial College to understand this [but you might need a PhD in epidemiology to misunderstand it], just basic arithmetic and common sense. Suppose 50% of the UK (33 million people) get the virus of which 5% (~ 1.8 million people) will need serious hospitalization [conservative estimate]. The current capacity of ICU beds in the UK is something on the order of 2000 beds , depending on occupancy rates, ability to scale up et cetera. Let's be extremely optimistic and somehow the UK is able to quintuple this capacity [as far as I can tell this is unlikely]. When somebody is sick they might need care for 2 weeks. The annual hospital capacity is: 25 weeks * 10.000 beds= 250k. At the moment the capacity is nowhere that (perhaps 50-100k). You can see that 1.8 million is far larger than 100k or even 250 k. Even wildly optimistic estimates will not yield anything realistic. This assumes that the government is somehow able to control the infection spreading over a year; instead of two months. There is no reason to think they can do this without extreme (partial) lockdown measures. Controlling the R0 is extremely hard. All the mild measures seem to help only a tiny little bit. If the R0 is only a bit over 1, we still have exponential growth; and you have merely pushed timelines back a few months. Can we perhaps expose young people but lock up older people for one-two years [when the vaccin might arrive]? I find this is extremely unlikely; you need only a couple people to flout the rules to wipe out an entire nursing home. Is it worth it to (partially) lock down the entire country for a year to save maybe a hundred thousand old people? There are only two real possible approaches: 1. Let the Boomers die. If we're lucky the death rate is ~0.7 percent. When (not if) hospitals overflow this will easily triple. Wi

3Roko5y

I agree with this analysis completely. There is a strategy bifurcation: Either you lock down hard and contain/eradicate, or you just accept the losses and tell people to go on as normal, with isolation of the vulnerable. The middle path is not favorable. You take both the human damage and the economic damage.

6Pablo5y

The South Korean approach seems to be roughly as effective as the Chinese approach but significantly less costly and disruptive. SK managed to halt exponential growth and currently cases are increasing linearly at a rate of 75 or so per day. This has been achieved without lockdowns or extensive border closings. Instead, the key ingredient appears to be rapid, extensive and largely free testing, and an educational campaign that stresses the importance of hand washing and staying at home.

5Raemon5y

I'm confused about why the second strategy works better than the first strategy at killing it permanently. If you shut down everything, shouldn't everything die out faster? (Unless you have open borders and let it in again, but wouldn't that also apply in the UK case?)

[-]gwillen5y150

The first strategy leaves you with a huge population of people with no immunity to the virus, which means you have to keep holding the lid on it indefinitely or you're back to square one.

In the second strategy, everyone ends up either immune or dead, which doesn't mean the virus is gone -- it will remain endemic -- but there will be no giant flood of new cases when people resume their lives.

(Obviously it's not quite as simple as that if the virus doesn't generate durable immunity. Then you end up with something like the flu, where partial immunity keeps it vaguely tamped down with occasional flares.)

9willbradshaw5y

Clarification: you don't need everyone to be immune or dead. Just enough people that the remaining population can't sustain a continuous epidemic.

4gwillen5y

Right, yes, agreed and good point -- my understanding is that a naive epidemiological model gives a fraction of 1 - (1/R_0) of the population needing to be infected, to drive the effective value of R (new transmissions per infected person) below 1, at which point the population can no longer sustain epidemic spread.

3Lukas Finnveden5y

Isn't this exactly what "flatten the curve" is about? Because a lot of people are talking about that as a solution, including some governments. The main problem is that the curve needs to get really flat for hospitals to have time with everyone. Depending on how overwhelmed you want your hospitals to be, you could be in lock-down for several years. Some calculations in this article.

1Mmv5y

Isn't "social distancing" the in-between strategy already? I was thinking of something similar today, when questioned whether to have a friend to my house. If I followed the strictest measures, I wouldn't. But then, if nobody did and we were essentially on self-quarantine mode, then the virus wouldn't spread at all or very, very, little and we would be hovering in small numbers for months, until next fall/winter, when it could get really risky again (presuming that weather has an influence, like with flu). So doesn't the social distancing strategy want some appreciable degree of transmission, high enough to get to herd immunity in a reasonable amount of time, but slow enough to avoid a hospital crisis? Are governments just relying on the idea that some people will ignore the suggestions, and we'll get a reasonable degree of transmission over time during social distancing?

1Liam Donovan5y

I'm pretty sure that's exactly what the UK is trying to do? I'm actually pretty confident that the UK government isn't planning to have " hospitals overload and many people die from lack of hospital care. ". Even if they were sure that was the best approach (and they just didn't think of your idea?) it would be completely unfeasible politically

1syllogism5y

But why can't we eradicate the virus? Let's say China shuts down international travel, keeps doing what they're doing, and then slowly eases back up in some area, letting the people in that city comingle and go back to work, but still restricting travel in and out. Let's say they get that city back running, with no coronavirus cases after a month. At the same time...Won't they also have basically eradicated other influenza there? Even if not entirely, there should be much less cold and flu, right? So as soon as coronavirus creeps back in, it should be much easier to contain. I guess my thinking here is, if coronavirus is much more virulent than the flu, and this type of containment works to almost eliminate the coronavirus, could China...actually eradicate the flu, at the same time? If not, why not? The problem comes in from other countries. If China goes to all this effort and the US, Europe, UK etc don't, do we would end up with this weird hazmat curtain? Asian countries would join China in eradicating the disease, and Australia and New Zealand would probably join them.

2gwillen5y

I've already heard that influenza cases are down in countries that enforced social distancing / lockdowns for coronavirus. However, it really only takes one country not doing this for influenza to return to typical incidence -- there's no real reason to believe it will be eradicated. (However, the same seems true for COVID-19, so I'm not sure what to expect there.)

1syllogism5y

I agree that actually eradicating influenza feels far-fetched. But on the other hand, it's quite a lot easier to work with than COVID-19. Influenza isn't nearly as infectious, most people have immunity, and it's barely transmissible at all when the carrier is asymptomatic. Imagine you actually did have the "hazmat curtain" situation. Everyone is asked to take their temperature on the way in, and significant fines (and potential visa cancellations) are imposed if you lie. At first nearly everyone is checked to verify, but this is relaxed to spot-checks as people get used to never breaking the rule. Few enough people are getting sick that when people do report influenza symptoms, they can be tested, and contact tracing can be employed to halt the outbreak and trace it back to how it was introduced. If there are no animal reservoirs for the disease, I think that could be viable? It's expensive, but influenza is a big cost in itself, in lost productivity and other problems. The big problem I see for eradicating coronavirus will be in poorer countries --- Africa, the middle east, etc. The outbreaks there are still pretty small, but there's no real resources to address them, so the problem could grow there until it's really hard to fix.

[-]Pablo5y*380

Update: the positions are now filled. See here for the official announcement.

Help wanted: pandemic.metaculus.com project lead

The high interest and proliferation of questions on the novel coronavirus calls for dedicated attention, which led to the formation of pandemic.metaculus.com. Managing it, though, is straining Metaculus's very limited staff and community moderator team. Contingent on acquisition of funding (which Metaculus is working to secure), Metaculus is looking to bring onboard someone to help manage this project. Components would include:

Managing the pandemic site and question series as a sort of "editor in chief" working with the community moderators (as Tamay does now for Metaculus in general.)
Helping build data products and analyses out of the questions and results.

The above indicates a range of skills including pretty strong understanding of Metaculus, and data analysis capability. Science background would be great, and huge bonus for actual medical knowledge. This is probably a part-time role but full-ish time is also imaginable depending upon the person, the duration, and funding.

If you're interested, please send a note and CV to jobs@metaculus.com.

[-]jimrandomh5y360

If this news article is accurate, masks will not be scarce for much longer. That article claims that China is now producing masks at 116M/day, a 12x increase compared to the start of February (5 weeks ago), and that they will export them. This is in addition to mask production in other countries.

I am not sure whether, when combined with production in other countries, this satisfies the entire world demand. But masks aren't complicated objects and aren't made of scarce materials, and this is pretty strong evidence that production can be scaled up even further, if necessary.

In a few weeks, a number of public figures may find themselves doing an awkward about-face from "masks don't work and no one should wear them" to "masks do work and they are mandatory".

(If you are able to buy masks for less than $1/each through ordinary channels, it means the shortage has abated, and you can buy them without worrying about depriving health care workers of those supplies, but you shouldn't stock up on more than you need in the short term until the price has been low for at least a few weeks.)

[-]Bird Concept5y100

In a few weeks, a number of public figures may find themselves doing an awkward about-face from "masks don't work and no one should wear them" to "masks do work and they are mandatory".

I want to record and reward how this prediction seems to be correct: https://www.washingtonpost.com/health/2020/04/02/coronavirus-facemasks-policyreversal/

1agc5y

I wonder if China will direct the masks to politically friendly countries, or let the free marker decide.

3Emiya5y

They'd likely ship them out to everyone as fast as they can, this is their chance to regain political points after this disaster. They already helped out Italy by donating medical supplies and enough people on the social medias are starting to regard them with a better opinion than other European countries, so as a political move is hugely effective.

2jmh5y

I would think that would be the smart thing and the right thing. I suspect it also the thing they will do. That said, they have also already publicly stated (reported a few days back) they will offer that type of support "for those participating in their belt and road" initiative and I didn't notice (but did not read closely) if they mentioned nonparticipating countries and where they would stand. Might be more about prioritization in the line.

[-]jimrandomh5y350

I heard a rumor of someone in the Bay area claiming to work in the intelligence community, to be terminally ill, and to have received an experimental COVID-19 vaccine. I think this rumor is false with respect to the specific person, but do note that "military officers with preexisting terminal illnesses who volunteer" is a group that may actually exist, and that at least one drug company claims to have shipped vaccines for a phase 1 trial on Feb 24.

This raises the question: if you're well resourced, desperate, competent, and in possession of expendable military volunteers, how long does development for a vaccine actually take?

Given a candidate vaccine, you need to do three things: find out if confers immunity (and how much immunity), find out if it causes side effects severe enough to not be worth it, and scale up production.

All three of these can be done in parallel. If you have expendable volunteers, you don't need to start with an animal model; you can just give them the vaccine, and see whether they suffer side effects. Testing efficacy can be done in parallel, with the same volunteers, and takes about three weeks--you give the vaccine, wait a week, expose to virus, then wait i

... (read more)

5Ŀady Jade Beacham5y

For me, that fits my model of what the US intelligence agencies used to do during the cold war times, and we have unclassified documents about proactive, unethical experimentation they did - like Operation Sea Spray and MK Ultra. I don't know if the 2020 US intelligence community is up to the same task. I get the impression that capability and competence have fallen there, although it's hard to know since so much is classified. But judging by the fact that we have had several elections disrupted by pretty predictable cyberattacks without visible countermeasures, my estimation of their competence has fallen. On the other hand, here's an article about a UK laboratory infecting people with a non-covid coronavirus to help with vaccine research.

2Adam Zerner5y

But the space of possible vaccines is very large, I assume. So even with a ton of human testing that only takes three weeks, maybe this still doesn't help much?

4jimrandomh5y

In principle, with enough resources, multiple vaccines could be tested this way in parallel. Not that there are that many vaccine candidates to try, as far as I know; but if there were some software that bulk-generated candidate molecules, it could be done, in principle. The limiting input is mobilized resources, not time.

2ChristianKl5y

We have the genome of the virus. All the surface proteins of the virus are candidate molecules.

2Adam Zerner5y

Yeah, if you could reduce the space of possible vaccines to a smaller set of plausible ones, that certainly makes sense. This makes me wonder, why not just let people volunteer to test risky treatments in general? Because there'd be bad actors who try weird shit willy nilly and misrepresent it to people as more plausible than it really is, such that the harm done to people outweighs the advancements in knowledge? But what if you remove the profit motive and only give this power to government researchers? Would they have too many career-y incentives to be too aggressive?

2ChristianKl5y

Human trials are much more expensive then trials in mice. If you can already rule out a drug by giving it to mice you save a lot of money that you don't have to invest into your trial with humans.

2Adam Zerner5y

True. The downside would be that animal testing is slower, which is I think why jimrandomh was proposing human testing.

2ChristianKl5y

Speed is not an important variable for government researchers outside of a situation like this where you need a fast response to a pandemic. Speed matters a bit more for big pharma where it matters if you have one additional year of patent protection for your drug if you develop a year faster but even there the cost tradeoffs are in favor of doing animal testing.

2ChristianKl5y

It seems to me much more likely that the Chinese are doing human trials that skip animal testing then that the US intelligence community does that. Terminally ill patients don't make good subjects for clinical trials. If you run such a project outside of the reach of the FDA, it seems like a slight against the FDA. It's not a step in which companies that produce vaccines and that want to have good relationships with the FDA want to make. On the other hand the Chinese government has plenty of people in their prisons that they consider expandable and willing to sacrifice for the greater good. They should also have less institutional resistance to it

2jimrandomh5y

The "terminally ill" bit was part of the (probably false) rumor that I heard. Preexisting illness definitely screws with the safety-testing aspect, but there are also illnesses don't interfere with the efficacy testing. I agree that a competent agency uses healthy people for this if they could. If experimenting on healthy people wasn't possible or worth it, one possibility would be to do an efficacy trial on unhealthy people and a safety study on animals in parallel.

2ChristianKl5y

I have the impression that you ignore the institutional issues that are at play. The intelligence community can't simply deploy a vaccine on their own. They need buy in from the FDA.

[-]jimrandomh5y180

Legally speak, yes they would. Practically speaking, however, the FDA has no enforcement power over secret programs in the intelligence community.

I think a lot of people are seriously overestimating the FDA's actual power, and that's causing pretty severe problems. Consider for example this tweet (and a long series like it) by the mayor of NYC, begging the FDA for approvals. While there is no legal precedent to refer to, it's extremely implausible that the FDA could ever get or enforce a judgment of the city of New York for actions taken during a state of emergency, when the FDA itself caused that emergency with culpable negligence.

0ChristianKl5y

The FDA has no power to stop the intelligence community running tests on patients but they do have the power to declare the results of the tests as not being enough to prove the resulting vaccines safe. Do you really think that you have a better idea of the institutional power of the various players then the mayor of NYC? The FDA has a lot of relationships that allow it to exert power that are distinct from direct legal tools.

1Original_Seeing5y

There are some articles today about people trying out a drug called remdesivir https://www.washingtonpost.com/business/economy/the-best-hope-for-coronavirus-treatment-is-an-experimental-drug-that-fizzled-against-ebola/2020/03/10/8a9e8cd4-5fe8-11ea-b29b-9db42f7803a7_story.html

-3eternaltraveler5y

In general vaccines are very easy to make. You grow the virus you want to vaccinate against, kill or weaken it, and inject it, often with an adjuvant. Viral illnesses that don't have vaccines today are the exception where it turns out that doesn't work and it's more challenging. These difficult ones are what all vaccine research today is focused on, so people think making vaccines is hard. It usually isn't. Small pox, measles, mumps, rubella, chicken pox, and polio are all gone. Flu is 4 new viruses we make brand new vaccines for every year.

[-]Matthew Barnett5y330

Are the economic forecasts still too sunny?

(Warning: Long comment)

Two weeks ago Wei Dai released his financial statement on his bet that the coronavirus would negatively impact the stock market. Since then (at the time of writing) the S&P has dropped another 9%. This move has been considered by many to be definitive evidence against the efficient market hypothesis, given that the epistemic situation with respect to the coronavirus has apparently not changed much in weeks (at least to a first approximation).

One hypothesis for why the stock market reacted as it did seems to be that people are failing to take exponential growth of the virus into account, and thus make overly optimistic predictions. This parallels Ray Kurzweil's observations of how people view technological progress,

When people think of a future period, they intuitively assume that the current rate of progress will continue for future periods. However, careful consideration of the pace of technology shows that the rate of progress is not constant, but it is human nature to adapt to the changing pace, so the intuitive view is that the pace will continue at the current rate. [...] From the mathematician’s

... (read more)

[-]Vaniver5y140

The idea that smart investors don't understand exponential curves is absurd on its face

I don't think this is necessarily absurd or false. Like, this is what Black Swan Farming was about.

I think people in finance are used to exponential curves with doubling times of 20 years, and this doesn't give them much of an edge when it comes to doubling times of 2 days. Like, even in semiconductor manufacturing, the progress of Moore's Law over someone's 40-year career corresponds to about a month of viral growth at that rate.

Startup finance people do work with stuff at roughly the same scale, and correspondingly freaked out much more.

The sheer insanity of such a prediction should give you an idea of how uncertain this whole thing still is.

I don't think this is crazy, once you consider healthcare system failure. What does the world look like if no one receives medical care for any condition besides a COVID infection for the next three months?

3romeostevensit5y

I don't have a strong stance either way but I think there are some interesting points for the other side. Let's say this is on the order of a ww2 number of deaths. Look at the impact of ww2 on the economy. Except with the present situation there's no need to halt international trading, and none of the productive assets get bombed. This still leaves a lot of room on the side of it being worse than many of these sunny projections, but what I want to point at is that it is also really common to drastically underestimate how bad things can look locally and still have trends mostly do alright due to the enormous differences of scale between what it takes for things to look bad and what it takes for things to be bad everywhere.

[-]AlexSchell5y*330

This blog post argues that the now popular idea of "flattening the curve", in the sense that most people get exposed but slowly enough to not overwhelm the health care system, is not feasible. The result is that we'll either achieve containment or at least widespread regional health care system collapse (and maybe Wei Dai's global health care collapse outcome). I haven't spent much time modeling this yet, but tentatively it looks like flattening the curve requires very precise fine-tuning of R0 to stay on a path very close to 1 for at least several months, which seems impossible to pull off.

It feels to me now that flattening the curve is just a nice graphic without anyone checking the math, but I am confused that many informed-seeming experts are promoting the idea. Anything I'm missing?

ETA: I made an epidemic + hospitalization model (Google Sheets), it sure looks like the usual flatten-the-curve chart is a comforting fiction. Peak hospital bed demand in the uncontrolled epidemic scenario is usually drawn at 2-3x hospital capacity. I'm getting 25x and the chart looks a lot less reassuring. My shakiest assumptions are hospitalization / intensive ca... (read more)

[-]paulfchristiano5y220

Disclaimer: I don't know if this is right, I'm reasoning entirely from first principles.

If there is dispersion in R0, then there would likely be some places where the virus survives even if you take draconian measures. If you later relax those draconian measures, it will begin spreading in the larger population again at the same rate as before.

In particular, if the number of cases is currently decreasing overall most places, then soon most of the cases will be in regions or communities where containment was less successful and so the number of cases will stop decreasing.

If it's infeasible to literally stamp it out everywhere (which I've heard), then you basically want to either delay long enough to have a vaccine or have people get sick at the largest rate that the health care system can handle.

5Sammy Martin5y

South Korea, Singapore, Italy The UK. We're running an interesting experiment to see which approach works. One potential benefit is that the world will be able to observe which of the two strategies is viable and switch between them, at least theoretically. Practically, switching from 'suppress/contain' to 'flatten curve' seems a lot more feasible than the alternative of trying to suppress after not taking tough measures, as the UK will have to do if its strategy means cases grow out of control. South Korea could still try to use curve-flattening as a backup plan. However, for the reason given in the blog post, suppression will be a viable backup even if switching from curve-flattening to suppression is intrinsically harder than the other way round.

5AlexSchell5y

Still seems to me like you should be able to isolate those problem areas from the rest of the country. Then even if you can't contain the epidemic inside, you spare most of the country (for the moment). But I think we mostly agree. A scenario that seems increasingly likely to me is that governments will intervene in increasingly strict ways until we get very close to true containment (before ~15% of the world is infected), and then will loosen movement restrictions in more-contained areas while playing whack-a-mole with a sequence of localized outbreaks for 1-2 years until a vaccine is ready.

2Roko5y

Borders, travel restrictions, cancellation of large events, contact tracing and testing will solve this. Borders are necessary precisely because of this dispersion issue.

[-]gwillen5y120

That's an interesting question that seems like it ought to be able to be checked numerically.

I made an attempt using this simulator of the fairly-naive "SIR" model of disease transmission:

http://www.public.asu.edu/~hnesse/classes/sir.html?Alpha=0.3&Beta=0.07&initialS=1000&initialI=100&initialR=0&iters=50

Note that this simulator appears to be someone's class project. However, its behavior seems to track more or less with what I'd expect. But I'd love for someone with more experience to reproduce this relatively simple model and check it.

You can read about the model at https://en.wikipedia.org/wiki/Compartmental_models_in_epidemiology#The_SIR_model .

I have limited confidence that I've understood it correctly, so take this for what it's worth. It looks to me the time step used in this simulator is one day. So the gamma parameter (rate of recovery per unit time) should be (Wikpedia says) 1/D where D is the duration of the disease. (For transmission modeling purposes, this should be the infectious duration, not the duration of symptoms.) I chose gamma=0.7, meaning D ~= 14 days, semi-arbitrarily, based on https://www.medrxiv.org/content/10.1101/2020.03.05.20030502v1 (

... (read more)

[-]AlexSchell5y110

Thanks for pointing me in this direction. I think the key worry highlighted in the post is that the health care system gets overwhelmed with even just a few percent of the population being infected. So even if we can bring peak infections down by a factor of 2-4 by slowing transmission, the health care system is still going to be creamed at the peak.

I've now built a discrete-time, Bay Area version of the SIR model (+ hospitalization) in this Google sheet. I assume 20% of infections need hospitalization, of which 20% need intensive care, and use raw bed-to-population ratios (non-COVID utilization vs stretching capacity should roughly cancel out). Hospital bed availability at peak infections is 4% (25x over capacity) in the uncontrolled beta=0.25 scenario and only improves to 10% (10x over capacity) in the "controlled" beta=0.14 scenario. Even if my hospitalization/ICU numbers are too high by a factor of 5 the "controlled" scenario still looks pretty terrible. Any feedback on the model assumptions would be super useful.

5gwillen5y

I haven't checked your models quantitatively, but qualitatively I absolutely believe you that the options here are "bad" and "really really bad", and that neither one of them gets us down to where we need to be. The difference between 4% and 10% could still save a lot of lives; at that level it may be close to 1:1 (every bed freed up is a life saved), since only the most critical cases will be getting beds at that point. But you're right that this is clearly not adequate, and the graphic showing the flatter curve as peaking under the capacity line is pretty misleading. (There are versions of the graphic which don't, but they appear to have been memetically outcompeted by those that do.) I think it's still true that "flattening the curve" will save lives, potentially a lot of lives, so even if the graphic might be a bit misleading as to the possibility of flattening it below the critical threshold, I think it's still a reasonable meme to promote. But really the ultimate goal has to be reducing R below 1, which will arguably flatten the curve, just not quite in the way the meme seems to be trying to get at. I don't want to steer too close to dark side epistemology here, but if the meme gets people to stay inside, cancel their parties, and wash their fucking hands... it's hard for me to be too against it, and I think it's probably true enough?

4AlexSchell5y

I don't know how other people react. I took the epidemic fairly seriously but my initial reaction to the meme was one of reassurance/complacency - OK so I can't avoid eventual exposure anymore, but at least things will proceed in a somewhat orderly fashion if we cancel big events, wash hands, stop touching our face, etc. I feel like this is the sort of attitude that contributes to, and allows the public to accept, decisions like the capitulation in Sacramento. The mental image of mitigation is "basically trying to mitigate the risk to those who are most at risk: the elderly and those with chronic underlying conditions". The reality is that we'll be forced to let all the old and sick die in hospital parking lots. It seems to me fairly likely that the public will ultimately accept the Hubei-style lockdowns that will result in containment, but this meme probably is responsible for delaying that moment by at least a few days :(

[-]Raemon5y100

I saw the meme as mostly targeting people who were currently even more complacent "eh, there's nothing we can do, so fuck it", and getting them to instead go "okay, there's stuff that's actually worth doing."

4AlexSchell5y

You're probably right.

3WilliamKiely5y

Alex, I'm looking at your spreadsheet and I don't understand where you got these bold numbers from. It looks like you tweaked your sheet a bit since writing this comment, but still I can't figure out what you are looking at when you say 25x and 10x over capacity. Could you explain?

4AlexSchell5y

Yeah I got better hospitalization/ICU rates from Bucky and upped beta to 0.3 in uncontrolled scenario to make a point on Twitter. Hospital/ICU bed availability % is graphed in each scenario tab, by overcapacity I mean the inverse of availability. Alternatively take ratio of peak to line in the Charts tab. Looks like ~15x and 5x now for hospital beds.

[-]Wei Dai5y100

That's a really interesting blog post, and it made me update (towards the idea that containment efforts in most countries will keep ramping up until containment actually succeeds). How did you come across it? I've been following Twitter, a couple of FB groups, and Reddit, and it didn't get linked by any of the posts I saw.

It feels to me now that flattening the curve is just a nice graphic without anyone checking the math, but I am confused that many informed-seeming experts are promoting the idea. Anything I’m missing?

I'm wondering this too.

3AlexSchell5y

Don't recall how I ended up seeing it, but it was through this tweet by the author: https://twitter.com/DanielFalush/status/1236918870780198912 (ETA: Razib Khan RT'd him)

2Sammy Martin5y

Perhaps the numbers work out better when you include cocooning of populations that disproportionately make use of hospital resources

5Unnamed5y

I think each little bit of curve flattening makes things a little less bad (since a smaller number of cases are beyond capacity, and a little more time is created to prepare), but the graphs tend to draw the "capacity" line unrealistically high. This graph is more realistic than many since the flattened curve still peaks above the capacity line, but it still paints too rosy a picture.

4Bucky5y

Nice model. For hospitalisation / intensive care, the original data from China had 14% "severe" and 5%"critical" cases. These are percentages of diagnosed cases so you would need to modify these with the diagnosis rate. For the Diamond Princess about 50% of cases were asymptomatic so that is likely an upper limit on diagnosis rate. Ascertainment rates from these papers are highly variable so an actual number here is hard to estimate. That suggests hospitalisation is probably no more than 10% and intensive care no more than 2.5%. These numbers are a bit lower than your model but not enough to get us out of the woods.

4Sammy Martin5y

From the blog post: I have heard '5-15%' and '20%' and '12%' for hospitalization/'no-treatment fatality' rates, with a trend that the newer estimates tend to be lower. The initial figure from China was a blood-curdling 20%, as you said, while a current projection based on evidence from real overwhelmed healthcare systems is a merely very bad 3-5%. This is lower by a larger factor than most of the reductions to the CFR that account for undocumented cases - perhaps indicating there are more undocumented cases than those corrections imply? Also, of relevance to the UK's strategy (cocooning older people from infection), how does this breakdown by age? This poster has estimated that young, male, no pre-existing condition have 1/4th the risk of hospitalization (assuming a 50/50 chance that the intersection of age-30/no-pre-existing condition has a much lower risk than either alone) - which means if older and vulnerable people can be 'cocooned', the actual rate of hospitalization can be slashed again by a factor of 4 to something bearable, around 1%, if you take 4% as the baseline. (note that the corrections in this paper for delay to death and underreporting skew the death rates even more strongly towards older patients, with the fatality rate among 20-29 barely changing after adjustment but the fatality rates among 60+ doubling). That means you could surf a wave of a few hundred thousand people having the virus at a time and still provide adequate ICU space. With some expansion in capacity, that could be even higher.

4AlexSchell5y

Thanks for digging these up! I updated the model. Still terrible.

3jmh5y

I'm wondering why you are also coming up with a LOT more hospitalization than even cases reported in China. In early April, if I'm readying this right, you are expecting the Bay area to need over 80,000 hospital beds for COVID-19 for the uncontrolled case (I assume that is merely a comparison scenario) and then after 3 months, say starting July, in the controlled scenario about 81,000 hospital beds will be needed. Then things keep going up. That seems like something is missing there. Why would the Bay area really expect to see such drastically higher impact than China as a whole? Using your 20%, 20% assumption and saying China is at 85,000 now, the total demand for hospital beds would have been 20,400 over the entire December - March time period.

4AlexSchell5y

China locked down Wuhan at ~500 confirmed cases and many other Hubei cities the next day, which immediately lowered transmission (see Chart 7 here) to R0 below 1. This is very far from the uncontrolled scenario and still overloaded the health care system. This is much of the point of the post I linked -- the degree of hospital overload in an uncontrolled scenario is so high that even huge reductions in transmission don't realistically avoid overload if R0 stays above 1.

1jmh5y

I do get that point, and do think it is one that is well made. At the same time, I find the numbers produced a bit on the high side. Clearly the 20,400 number being within existing capacity for the Bay area completely ignores current patients unrelated to COVID-19. But perhaps under a regime of social distancing, containment and isolation of both known cases and by the more concerned both the speed of growth and the total number your model is producing would be much closer to manageable.

3jmh5y

I think it might also be worth considering hospital beds -- to some extent -- is not a fixed quantity to can expand as demand increases. Consider using hotels or other (these days rather vacant) building/structures. That's basically what China has done here (and in other cases with their "legos" 10 day to build hospitals -- rejected the concept of what a hospital is and how fixed the supply is. Just as an assumption check, was your hospital bed/ICU bed value an average for, say the USA, or some other country level metric or an average of the local hospital to service area metric?

2AlexSchell5y

I used overall US numbers. I didn't consider capacity expansion but also didn't take out already-occupied beds, as I think both are roughly on the order of 2-5x in opposite directions. The only Bay Area-specific numbers are population and day 0 infected (I assumed ~10x confirmed cases).

1zby5y

It worked in 1918: https://qz.com/1816060/a-chart-of-the-1918-spanish-flu-shows-why-social-distancing-works/

2AlexSchell5y

I should have made it clearer I don't deny we can literally flatten the curve, but rather the idea that Unclear to me how well St Louis did on the health care system front. Also, the pairing of Philadelphia and St Louis is a bit convenient if you consider the raw scatterplot (panel C bottom left - ETA Philadelphia is the dot closest to Pittsburgh per this table).

[-]Pablo5y300

I think it would be valuable to compile a list of estimates of basic epidemiological parameters of the coronavirus, such as incubation rate, doubling times, probability of symptomatic infections, delay from disease onset to death, probability of death among symptomatics, and so on. I find that my inability to model various scenarios accurately is often due to uncertainty about one or more of these parameters (uncertainty relative to what I suspect current expert knowledge to be, which is of course also uncertain to a considerable degree).

[-]Bucky5y180

For current expert knowledge, this list of values from lots of different papers might be helpful.

2Pablo5y

Wonderful, thank you so much.

[-]kdbscott5y120

Did you end up finding one besides the MIDAS network, or develop your own? I'm assembling a parameter doc for inputs to a rough model that accounts for ventilator & hospital bed capacity, since it seems like we're lacking that.

I encourage folks to add parameters w/ citations to the doc, I'll be active on it for the next few days.
If anyone knows of models that incorporate actual healthcare capacity, please share!

6Pablo5y

Thanks for putting this list together. I stopped looking after Bucky supplied the link to the MIDAS network list, since it seemed so comprehensive. For models that incorporate actual healthcare capacity, see this thread. One limitation of the models I've seen is that they fail to account for growth in such capacity. China responded to the realization that they didn't have enough hospitals by quickly building more hospitals. Maybe Western countries are less competent than China and it will take them longer to build the needed capacity. But it seems implausible that they will be so incompetent that capacity-building efforts will not make a significant difference.

5Eli Tyre5y

Having a list of of values of interest, with estimates and citations for each, would be great. But in addition, I gotta say, this seems like just about a perfect use-case for prediction markets: we have a bunch of individual, well operationalized scalars, for which accurate estimates that incorporate all of the existing information are of high value. Is anyone in a position to set up, or to subsidize, a market on these values?

4habryka5y

I second this.

2romeostevensit5y

And to start compiling a list of common problems with the parameter estimates being used. Eg I am seeing some models extrapolate naively from the fact that most cases are coming from the least controlled places with the widest uncertainty bars.

1rocurley5y

I'm also very interested in this. Here are some numbers I've been using: * Ratio of confirmed to unconfirmed cases (USA): 34 (50%), or 5 (5%) to 94 (95%) This is based on https://twitter.com/trvrb/status/1234589598652784642 , which estimated the true number of coronavirus cases in Seattle (as of 2020-03-01). I divided that by the number of confirmed cases in Seattle at that time. * Doubling time (USA): 4 ish (which I'm treating as 2 (5%) to 7 (95%). https://en.wikipedia.org/wiki/Template:2019–20_coronavirus_outbreak_data/WHO_situation_reports is how I'm getting 4ish. There are papers that estimate higher: https://www.nejm.org/doi/full/10.1056/NEJMoa2001316 gives 7, for example, but that appears to be in Wuhan post-containment.

3jmh5y

South China Morning Post had a story line a day or so back where Chinese experts were suggesting a 10 fold increase every 19 days. Interestingly the rate seems to be about double that if you look at the last 19 days. I did not look past the totals but suspect that is highly dominated by South Korea (seems to be slowing), Italy and Iran (these two do not seem to be slowing). Might also be interesting to put a latitude metric in as well -- while I have a "sense" that more equatorial areas have a lower incident (and may be spread rate) I've not seen that data plotted anywhere.

[-]Spiracular5y*270

Paper on some of nCOV's mutations

Incidentally, also strong evidence against it being a lab-strain. It's a wild strain.

Closest related viruses: bats and Malayan pangolins

Mutation Descriptions

Polybasic Cleavage Sites (PCS): They seem to have something to do with increased rates of cell-cell fusion (increased rate of virus-induced XL multi-nucleated cells). Mutations generating PCS have been seen in Influenza strains to increase their pathogenicity, and they had similar effects in a few other viruses. So it's not exactly increasing virus-cell fusion, it's actually... increasing the rate at which infected cells glom into nearby cells. Fused cells are called syncytia.

O-linked glycans : Are theorized (with uncertainty) to help the virions masquerade as mucin, so hiding from the immune system. (Mutation unlikely to evolve in a lab on a petri dish)

Arguments strongly in favor of it being a wild strain

It's not that similar to one of the known lab-strains, so it probably was wild
The "polybasic cleavage site" and "O-linked glycans" mutations would have required a very human-like ACE-protein binding site, so basically only human or ferret cells
O-linked glycans are usually evolved as an immune defense, which isn't something cell cultures do.

(Just following the recommendation to move this out of shortform so it can be tagged later.)

8Spiracular5y

Chinese virology researcher released something claiming it SARS-2 might even be genetically-manipulated after all? ZC45 and/or ZXC21 backbone. Claims that the RaTG13 genome was a concocted cover-up. After assessing, I'm not really convinced of the GMO claims, but the RaTG13 story seems to have something weird going on. https://zenodo.org/record/4028830#.X2EJo5NKj0v See here for my further thoughts on this. EDIT: After assessing, I'm not finding the GMO claims convincing. The RaTG13 story does seem to have something weird going on, and there's several people and papers that note weird inconsistencies (See the further thoughts, I don't have a simple explanation.).

4Spiracular5y

Additional little bit that reminded me of that cell-cell fusion trait... another paper described the SARS-CoV-2 autopsy results, and included this: Translation: The paper-thin, high-surface-area (for gas exchange) cells wrapping your lung balloons (the pneumocytes in your alveoli) fuse together with each other into an ineffectual, clumpy mess with a way lower surface-area-to-volume ratio. These are fragile cells to begin with; they don't even replicate themselves (other cells have to replace them when they break). They don't seem to be producing virus themselves, but they do seem to be getting badly screwed up by things the virus is doing.

3ChristianKl5y

What exactly does "lab-strain" mean here? Does it means a strain with a already published sequence?

[-]Spiracular5y*100

More specifically:

It was not genetically modified for use as a bioweapon
- The mutations don't resemble other well-known and well-characterized pathogenicity mutations too closely, in sequence or location
It probably wasn't cultured as cell-culture in a lab-setting for an extended period
The virus was not notable to science prior to this event

Or in other words, it doesn't look planned. Its most recent mutations look much more like a "natural variation let it jump species" sort of situation.

This doesn't address situations like, for example, "dead bats with a wild-type virus being left near a bunch of ferrets or pangolins," or something to that effect.

(ETA: Or... accidental release like this is still possible.)

1Spiracular5y

Despite the virus being characterized in pangolins, after looking into this, I now think it is basically incorrect to think of this as primarily a "pangolin virus." The pangolins were a dying canary in a coal mine, and probably caught it from something else that serves as the real reservoir species for this nCOV precursor*. See: further explanation here

[-]Slava Matyukhin5y240

Two facts:

HCoV-OC43 (one of human coronaviruses causing common cold) can generate cross-reactive antibodies against SARS.
Immunity to HCoV-OC43 appears to wane appreciably within one year.

Here's the paper which mentions both of these facts. (The actual paper is not important, I expect these facts to be well-known to coronavirus researchers, if the paper itself is not terribly mistaken and if I haven't misread anything.)

Even if cross-immunity is mild, won't it make sense to intentionally infect people with HCoV-OC43? Downside seems quite small compared to the number of deaths, and intuitively it seems that "mild cross-immunity" = "less severe SARS-CoV-2 cases", which is extremely valuable.

I notice I'm confused, since these facts should be well-known to pretty much everyone who's working on the vaccine. What's the explanation for why it's not a good idea?

Possible explanations, but I'm probably missing something:

Vaccines which cause the actual illness are considered unethical. (Probably not? I don't expect humanity to be that stupid.)
Mass-producing HCoV-OC43 virus is too hard for some reason. (Possible? I don't know much about vaccine production, and I'm clueless about whether

... (read more)

6Elizabeth5y

There's speculation that having acquired immunity to similar viruses leads to worse outcomes with COVID-19, and that's why children don't have many symptoms. This is still highly speculative, I won't be surprised if it turns out to be something totally different, but it would make me nervous about this plan.

4Slava Matyukhin5y

Okay, SARS-CoV-2 is pretty different from SARS-2003 ("~76% amino acid identity in the spike protein"), this might be the reason it won't work. OTOH, I don't know how different HCoV-OC43 is from both SARS strains.

3Spiracular5y

Similar to the thing Elizabeth mentioned, I'm concerned about the possibility of antibody-dependent enhancement wherein an imperfect antibody match actually worsens the course of the infection. I've tried to look into this. My results weren't conclusive, but I think it's a very real possibility for this virus, and fairly likely to slow vaccine development due to the added testing it neccessitates. I opened a question on it here.

2gwillen5y

I would also like to know the answer to this. One thing I'm not sure about: how hard is it to get your hands on HCoV-OC43? With high confidence and in quantities suitable for pretty much guaranteeing to give someone a cold / some immunity? (Do excessive quantities lead to a more severe cold?) This does really seem like something someone should be working on. Probably someone is, somewhere... EDIT: Here is one paper on the consequences of HCoV-OC43 infection: https://www.ncbi.nlm.nih.gov/pubmed/23337903 Among other things: "Recent studies have suggested [that human coronaviruses] can cause severe lower respiratory tract illnesses in children." and "In our population, HCoV-OC43 infections generally caused upper respiratory tract infection, but can be associated with lower respiratory tract infection especially in those coinfected with other respiratory viruses." So safety might be in question. EDIT 2: Scihub link: https://sci-hub.tw/10.1097/INF.0b013e3182812787 EDIT 3: I would really love for someone who knows things to take a look at this paper actually, and help interpret it. It is only studying children, and notes that "HCoV-OC43 infections tend to occur before 2 years of age" (does that mean adults can't get it? or they aren't exposed to it much? Does exposing them to it generate a useful immune response?), and also that, among the children selected for the study, children with HCoV-OC43 had better outcomes than controls (but I have no idea how to normalize this for statistical issues; the subjects were children who tested positive for HCoV-OC43, whereas the controls were children who were tested for respiratory viruses but were negative for HCoV-OC43.)

[-]Eli Tyre5y230

This paper is well worth a read, according to me. Given that we have all kinds of problems doing testing for COVID-19 in the US, the authors do an analysis of the ratio of people seeking medical help for flu-like symptoms, but testing negative for the flu, to people testing positive (compared to previous flu seasons). The idea being that if COVID-19 is spreading, we should be seeing increases in flu symptoms relative to flu diagnoses.

However, I'm confused about Arizona. (See figure 4 in the paper). It looks like its score on this axis has been 2 to 3 standard deviations from the mean for the decade since November.

What's going on?

Hypotheses:

The Flu season in Arizona was so bad this year that the number of people who came in with flu symptoms skyrocketed, relative to other kinds of ailments, and even though most of those people did test positive for the flu, the wILI term swamped the (1 − proportion of tests positive for influenza), for an overall much higher than usual ILI-.

Is that mathematically plausible?

There was some other flu-like non-flu that was spreading in Arizona since November.
The flu diagnosis process spontaneously failed this season, producing orders

... (read more)

4Elizabeth5y

Based on figure 4, this would predict that the midwest would have a worse epidemic than the pacific NW right now, and twitter reports from hospitals don't seem to bear that out.

[-]Elizabeth5y190

Why are we prioritizing testing the sickest people? AFAIK diagnosis doesn't change what care is given, so it's irrelevant to them. Testing people who might be sick and take high impact action based on the results (e.g. medic deciding whether to go to work) seems higher impact.

Possible explanations: sickest people get the most positives and that's important for contact tracing, I am wrong about how it affects care (in particular it might affect if you get an isolation room or no)

2gwillen5y

My assumption has been that the primary purpose of testing is for contact tracing. I would suspect that probably don't have enough tests at this point to usefully test everybody who is ill and yet still planning to go to work, even just people with healthcare jobs -- I'm assuming that someone who is ill, but still thinking about going to work at their healthcare job, is probably not very sick, in which case most of those tests would end up negatives, on people who just have colds/flu.

1syllogism5y

Most tests you carry out on anyone else will be negative, so even if you think there's an 80-90% chance the patient is COVID-19 positive, you still get more information from running those tests than the lower symptomatic people. Also, it does change all sorts of decisions. It probably changes what precautions the healthcare workers need to take, and it lets you tell the person's family to self-isolate. Otherwise the husband is in critical condition, and the wife might be a week behind, so she's in the waiting room making everyone sick.

2gwillen5y

Hm, can you say more about information? I believe you should get the most direct information (in the information-theoretic sense) out of running tests where the outcome is most in doubt (i.e. where your prior is approximately 50%, although I think this might budge a bit depending on the FP/FN rates of the test if they are different.) You also get information about their contacts -- if their contacts have a lower-than-50% base rate of exposure, then it seems like you get more of that "secondary information" from a positive than from a negative. (I'm not too confident about that, but certainly at worst it's equal, right?)

1Original_Seeing5y

An accurate count of how many people are infected may be a highest priority. Since the virus has exponential growth, the difference between a known count of 10 infected vs 100 infected is massive in terms of policy decisions. Undercounting is extremely dangerous to the entire population. This could change once the number of infected patients gets very high, but we may not have seen numbers high enough to justify that anywhere outside of China yet.

[-]gwillen5y180

Several counties in California are now advising people not to bother self-quarantining at home after COVID-19 exposure unless they get symptoms. This seems wildly irresponsible to me. I understand not wanting to use valuable health system resources on people who are unlikely to have the virus, but home self-quarantine does not cost the health system anything now, and it is likely to save the health system a lot of cases later. Right?

https://www.sacbee.com/news/local/health-and-medicine/article241047391.html

This seems in particular very much at odds with Italy's striking decision to lock down the entire country, including whole regions with no known exposures.

Any thoughts?

2Elizabeth5y

Reading between the lines, it sounds like they're no longer contact tracing. I would interpret this to mean they're not tracking down people to recommend that they, specifically, self-isolate, but it's not a blanket recommendation not to self-isolate. They also don't seem to recommending that, but it's not clear they ever did.

2gwillen5y

I think that would have been a very reasonable thing, but no, it is a blanket recommendation that self-quarantine for known exposure is not required (at least for Sacramento County): https://www.saccounty.net/news/latest-news/Pages/County-Announces-New-Mitigation-Efforts-COVID-19.aspx "With the shift from containment to mitigation, it is no longer necessary for someone who has been in contact with someone with COVID-19 to quarantine for 14 days. This applies to the general public, as well as health care workers and first responders. However, if they develop respiratory symptoms, they should stay home in order to protect those who are well. "

[-]gwillen5y160

What are the issues involved in receiving delivery food during this pandemic?

Can one safely receive and eat delivery food as follows: Avoid contact with the deliveryperson (have them leave it outside), carefully dispose of the packaging in the same way you would for a package delivery, then take the delivered food and reheat it in the oven for a time/cooking temp that will kill the virus?

The respiratory viruses as a family do not appear very resistant to heat (as compared to e.g. some of the foodborne illnesses.) From https://www.quora.com/At-what-temperature-does-the-cold-virus-die/answer/Thomas-Basterfield (I didn't check the citations yet), it seems like 70C for 25 minutes will kill most respiratory viruses thoroughly. This is such a low temperature that I wonder if hot food is inherently inhospitable to them even without the reheating step. My oven dial doesn't even go that low. (Getting the center of the food to this temperature could be challenging without using a higher oven temperature, but you really only need to do the surface; the center has already been cooked, and any relevant contamination will be on the surface from post-cooking handling.)

(There is also a mention of

... (read more)

[-]Steven Byrnes5y110

I like the discussion in Food Safety and Coronavirus: A Comprehensive Guide. Note that the author has a conflict of interest, but I don't think he let it affect the article.

3gwillen5y

Thanks, I believe that article is great advice and I fully endorse it -- I saw it a few days ago but never came back here and updated my comment.

4Raemon5y

FWIW I think this'd make a good top-level question post.

4gwillen5y

Thanks, will maybe do that today, it's on the queue.

4Raemon5y

My preliminary look gave me a similar "huh, is cooked food just totally fine?" reaction, but I don't trust myself to have enough context to know the answer.

[-]Roko5y150

An review of Ferguson et al's paper by Nassim Taleb has come out: https://necsi.edu/review-of-ferguson-et-al-impact-of-non-pharmaceutical-interventions

I think this document contains the essential strategy for quickly bringing covid-19 under control. I'll call it "Containment and Eradication":

1. Close national borders

2. Reduce R0 below 1 using a thorough lock-down, social distancing, testing, contact tracing and hygiene

3. Once the outbreak is quite small and testing capacity is decent, aim to drive the number of infected individuals as close to 0 as possible

4. Test aggressively and wait a couple of weeks

5. Gradually return people to mostly-normal life, but with large gatherings cancelled for the foreseeable future due to the possibility of super-spreader events, and international travel mostly cancelled.

6. Keep borders fully closed to until we have a vaccine, or at least impose long quarantine periods on travelers.

Approaches to covid-19 that involve getting a large number of people infected to build herd immunity and minimize the damage along the way are far inferior to this. The Ferguson et al analysis showed us just how messy that would get, but I think it wa... (read more)

[-]habryka5y140

As part of the LessWrong Coronavirus Link Database, I am publishing a daily update post with all the new links we are adding each day that we ranked a 3 or above in our importance rankings. Here are all the links we added over the weekend.

Guides/FAQs/Intros

Coronavirus: Why you must act now (medium post)

Summary and call to action, one of the best summaries I've found, focuses more on policy-interventions than on individual actions, but is still good at giving you an overview

UpToDate: Coronavirus Overview

UpToDate very frequently has the best overviews over many crucial medical topics. Geared towards a more professional medical audience.

Letter to loved ones asking to take CV seriously

Well written, compassionate explanation of why this is worse than what we've seen before and need to take this seriously. A few pointers on where to get started

Early February 80,000 hours episode on Coronavirus (1h 18min)

Long episode on coronavirus. Includes all the basic information, and discussion of big-picture implications

Spread & Prevention

Masks help prevent infection in schoolchildren:

In a group of 10,524 Japanese schoolchildren, masks and vaccination decreased the chance of catching

... (read more)

[-]jefftk5y140

How useful is it to heat your house to 75F+? To heavily humidify your house?

3jp5y

Why not ask this as a question post?

3Ŀady Jade Beacham5y

Do you expect transmission to occur within your house? From a guest? Or at a grocery store or outside contact? Seems like it would only help in the in-house case. I expect this to be pretty far down the list of useful interventions

3gwillen5y

If you get delivery, or shop at a grocery store but avoid coming near the people there, a significant part of your risk may be from contamination of objects you bring home. In that case this question seems important.

[-]Jayson_Virissimo5y140

I’ve been keeping notes on corona virus risk reduction tactics and turned some of them into a webpage to share with my family and friends. The idea to to make them as quickly actionable/understandable as possible. This is the pretty version, but you can contribute here.

I'm very interested in critical feedback, including if any of these tactics are likely to be harmful/ineffective or if I'm missing anything high-value/low-cost.

8ChristianKl5y

I consider my copper wrapped stick to be a high-value/low-cost option. It allows me to open door handles/light switches without having to touch them with my hands.

[-]PeterMcCluskey5y130

A new paper: Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study says that vaccination for tuberculosis has a potentially large effect on COVID-19 problems. This explains some of the strange differences between countries. That's bad news for the U.S. (which hasn't required the vaccine), good news for some countries.

4gwillen5y

That's extremely interesting. I would love to see someone in our community who I trust to be good at statistics redo the analysis, since all the data is public. Apparently there are already multiple trials underway, though: https://www.sciencemag.org/news/2020/03/can-century-old-tb-vaccine-steel-immune-system-against-new-coronavirus . The Science article came out before the paper, so I wonder where the idea struck first. Apparently the broader pro-immune effects of the BCG vaccine for tuberculosis have been known or suspected for a long time; see e.g https://www.ncbi.nlm.nih.gov/pubmed/31055165 "Non-specific effects of BCG vaccine on viral infections", http://sci-hub.tw/10.1016/j.cmi.2019.04.020, which is a fucking wild read and I highly recommend reading the whole paper.

1zby5y

It is also a hope in type 1 diabetes: https://www.google.com/search?q=bcg+diabetes - this is really unexpected stuff.

[-]Steven Byrnes5y130

I'm still trying to understand how COVID-19 actually spreads. (Related to my recent question on touching-vs-breathing.) Based largely on this article, my current very-low-confidence belief (in decreasing order of importance):

Top transmission risk: Being near (2 meters) someone coughing ... or talking! Talking emits droplets / aerosols too. Is that the key to the pre-symptomatic transmission we know is happening? Hmm.
Second transmission risk: Air in or around public restrooms. Apparently a SARS carrier with diarrhea was a super-spreader, infecting people 200 meters away!! That same link also discusses evidence that COVID-19 virus is found around bathrooms.
Last transmission risk: Touching contaminated surfaces then my face. While I am ranking this at the bottom, it could still be important, and I continue to take the same gung-ho precautions as when I formerly thought this was the primary thing to be thinking about.

Again, very low confidence in all this. Thoughts?

[-]Jan_Kulveit5y130

We are looking for forecasters/"estimators" to help with estimating various COVID-19 parameters, such as number of infected cases, which will go into epidemic modelling, augmenting unreliable reported data. Ideally the end product should be the results of the modelling presented in a good web UI. If you would be interested in helping, reply privately.

Q&A: How does it compare to Metaculus? In a few important ways.

1. the estimates are not the end product, but an input to epidemic modelling software

2. in our UX, we want to clearly communicate the results of the epidemic are not pre-determined, but depend on actions humanity will take

3. we want to expose more of the uncertainties and underlying dynamic, as opposed to static forecasts

9ChristianKl5y

Have you thought about cooperating with Metaculus?

[-]Joel Chan5y120

Read the Imperial College COVID-19 Response Team report tonight. https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-COVID19-NPI-modelling-16-03-2020.pdf

The numbers are quite starkly grim, based on an epidemiological simulation model. They conclude that mitigation strategies (only isolating symptomatic people, social distancing only at-risk people) will at best reduce the load on the healthcare system to "only" 8x current surge capacity in UK/US, leading to estimated 1.1M deaths from COVID-19 alone (i.e., not considering possible deaths from other causes due to an overloaded healthcare system). Instead, suppression strategies (everyone socially isolating) need to be followed for 12-18 months to ensure that the load from COVID-19 stays within surge capacity, minimizing total deaths to the low hundreds of thousands, and buying time for a vaccine / treatment to help beat back a second epidemic after relaxing suppression measures.

I am curious about a few assumptions in their model (wish it was open-sourced!), and how this might change the estimate.

1) They assume a fixed ICU capacity (where I think the main limit is ventilato... (read more)

3Vaniver5y

My understanding is that the treatment requires significant monitoring and skill; the ventilation is often invasive (they have to get the tube into your lung, rather than just into your mouth). But for a while people have been suggesting compartmentalizing the medical system further. If you just want someone to be a 'ventilator nurse', able to intubate a patient and then manage a ventilator for that patient, could you do that with a 30-day training program? Seems likely and worthwhile, but will require some sort of emergency legislation to authorize in most places, and some rapid development of curricula and testing. Similarly, expanding production runs into legal issues. You may have heard about the volunteers who 3D printed ICU valves; they asked the company for blueprints, and the company threatened to sue for the IP violation. You might also have heard about the patent troll who sued the makers of a COVID19 test for infringement; they dropped the case once it was public that the use was a COVID19 test. It seems like a potentially sensible government action here is to nationalize (or otherwise force licensing) of technology that's useful in a disaster, with the government paying for the IP after-the-fact based on actual usage out of the overall disaster response fund. But in general, our 'peacetime' standards for medical devices are very high. If you want to take your toaster factory (or w/e) and start spitting out ventilators instead, there's a lengthy approval process because this is complicated stuff with many ways things can go wrong. When the alternative is nothing, it's probably good to have rush jobs available, but there's nothing in place (that I'm aware of) to allow this sort of rapid ramping.

4leggi5y

For intubation: * The patient is usually sedated/unconscious. (drugs need to be administered) * correct insertion of endotracheal tube ( endo ~ inside trachea = windpipe) The first hard part is getting the tube past the vocal cords in the larynx. This requires the correct positioning of the patient to be able to see the vocal cords. (fibreoptic scope sometimes necessary) and to align structures for easier insertion. Laryngospasm where the vocal cords come together to block the airway is a major concern. (the vocal cords coming together is a normal part of swallowing to prevent things going into the airways and contacting the cords will induce a spasm.) This can be reduced by using a local anaesthetic spray on the cords - essential if the patient is conscious (a rare situation). Correct placement of the endotracheal tube is critical. It must be within the trachea, above the carina (where the trachea splits into the main bronchi and definitely not into a lung). If the tube goes into a bronchus it means one lung gets air, the other doesn't. A bad intubation is worse than no intubation. For ventilation: * Fancy equipment or * Someone squeezing a ventilation bag. (+ oxygen supplementation) But ultimately, nurses/EMTs/medical students can be trained to do all this in a few days. If someone's competent and confident and has adequate back-up in-case of issues.

5Vaniver5y

I think we might want to be in the world where we train a substantial fraction of the recently unemployed, or the National Guard, or whoever to do this, which requires starting from a lower point than nurses/EMTs/medical students.

3leggi5y

There's a big difference between the process of intubation and maintaining a patient once intubated. Someone with no prior knowledge of anatomy and physiology intubating patients (even after intense training) would increase the risks to patients. A mistake could be fatal. Time is a crucial factor - less than 4 minutes to correct an issue (brain needing oxygen). Sedation/paralytic drugs need to be given. Dangerous in themselves. (an old saying re intravenous anaesthetics - dead easy, easily dead) Adequate supervision/ back-up would be essential. Aptitude of the trainee would also be very important. No room for getting stressed. 1st rule emergency medicine - breathe. Better for the more experienced to intubate and then training people on ventilator management / how to squeeze a bag at the right pressure and timing (when ventilators aren't available).

1leggi5y

Tracheal intubation in the ICU: Life saving or life threatening?

[-]Omid5y120

I'm a nurse in an at risk area. Should I shave my long hair like the Chinese nurses were doing?

[-]ChristianKl5y120

I know that a roommate of a friend if coughing regularly according to my friend. I'm living in Berlin. How likely is it that the roommate is having COVID-19 based on the available information? How careful should I be interacting with that friend?

[-]ignoranceprior5y110

Epidemiologist Behind Highly-Cited Coronavirus Model Admits He Was Wrong, Drastically Revises Model (archive)

Epidemiologist Neil Ferguson, who created the highly-cited Imperial College London coronavirus model, which has been cited by organizations like The New York Times and has been instrumental in governmental policy decision-making, offered a massive revision to his model on Wednesday.

Ferguson’s model projected 2.2 million dead people in the United States and 500,000 in the U.K. from COVID-19 if no action were taken to slow the virus and blunt its curve.

However, after just one day of ordered lockdowns in the U.K., Ferguson has changed his tune, revealing that far more people likely have the virus than his team figured. Now, the epidemiologist predicts, hospitals will be just fine taking on COVID-19 patients and estimates 20,000 or far fewer people will die from the virus itself or from its agitation of other ailments.

Ferguson thus dropped his prediction from 500,000 dead to 20,000.

Author and former New York Times reporter Alex Berenson broke down the bombshell report via Twitter on Thursday morning (view Twitter thread below).

“This is a remarkable turn from Neil

... (read more)

7Wei Dai5y

https://twitter.com/lookner/status/1243201734538821634

1Lukas Finnveden5y

That article is based on a twitter thread that is based on this article that is based on the parliamentary hearing that Wei Dai linked. The twitter thread distorted the article a lot, and seems to be mostly speculation.

[-]jefftk5y*110

I have a lot of hand sanitizer I bought for a dance weekend that is now cancelled. What should I do with it?

EDIT: I gave some to an immunocompromised friend, some to friends who have critical jobs, and the rest to a food pantry

5Gunnar_Zarncke5y

Keep them until you more clearly see what the best possible or most urgent immediate use turns out to be.

5ChristianKl5y

How about donating them to nearby retirement home?

2Elizabeth5y

Too bad ebay is no longer an option.

1FactorialCode5y

Facebook marketplace?

1agc5y

Put them on a table at work or school with a sign saying "fee - take one".

2jefftk5y

I mean, I can definitely distribute them randomly. I'm trying to figure out if there's something better to do with them. (They're also gallons, so a bit tricky to distribute)

2Ŀady Jade Beacham5y

If you are going to donate them I would suggest local hospitals or urgent cares might put them to best use. I wish we had managed to get some hand sanitizer, we only managed to find travel sized ones before shtf.

[-]jimrandomh5y100

Health care settings are likely to already be well supplied, and to be picky about which kind of hand sanitizer they use (even if it's just about getting an internal approval).

[-]Elizabeth5y100

I was feeling rudderless trying to do actionable CV research without a grounding in its basic science, so I took a step back to build a foundation. These are the top sources that were useful to me:

Medical Microbiology Chapter 57: Coronaviruses (less technical of the two, although still aimed at biologists)
Coronaviruses: An Overview of Their Replication and Pathogenesis

These have also been added to the links DB

[-]IL5y100

What's the best way to convince skeptics of the severity of COVID? I keep seeing people saying it's just a slightly worse flu, or that car accidents kill a lot more people, and so on. I want some short text or image that illustrates just how serious this is.

I found this heartbreaking testimony from an Italian ICU doctor: https://twitter.com/silviast9/status/1236933818654896129

But I guess skeptics will want a more authoritative source.

8Steven Byrnes5y

A nice figure is that 1 person infected with COVID-19 requires (I think) 100x the hospital capacity of 1 person infected with the flu - 30x likelier to need hospitalization, and they stay there 3x longer if they do (you'll have to check these figures, but it's something like that I think...). Then that connects to the nightmarish Italian hospital situation you mention, and the fact that the death rate is dramatically higher without available hospital beds, including for young healthy people.

5Lukas Finnveden5y

Angela Merkel says that 60-70% of Germany is likely to be infected. That's useful if people believe that it won't infect that many. Example source, though you can google for others. If they're willing to believe a redditor's summary, this one says that WHO says that 20% of infected people needed hospital treatment for weeks. (If they want primary sources, maybe you could find those claims in the links / somewhere else.) Putting together 1 and 2 (and generalising from Germany to whatever country they're in), they ought to be convinced that it's pretty severe.

4jdfaben5y

It is now literally not true that car accidents kill more people, in either the UK or Italy, and won't be true in the US in about a week. I've found the time-delayed log graphs like this one pretty convincing: https://images.app.goo.gl/iKrfzw9Wt7hAqkVB6

4gwillen5y

For today, I have been directing people to this chart of Italian intensive care hospitalizations and deaths, 2020 COVID-19 vs 2018-2019 flu season: https://twitter.com/DellAnnaLuca/status/1236805732525207552 (Source: http://www.biotecnologi.org/ecco-perche-il-coronavirus-non-e-una-semplice-influenza/) As well as this news story about Italy banning all public gatherings across the whole country: https://www.bbc.com/news/world-europe-51810673 Plus the fact the the stock market is down >10% over the last week...

1Ofer5y

Maybe citing the CDC:

[-]TurnTrout5y100

Should poly people consider stopping intimate contact (hugs+) at some point? The network structure of polyamorous relationships might make people particularly vulnerable.

5MaxCarpendale5y

Having all partners isolate together is maybe another option for small polecules who all get along well.

3Ŀady Jade Beacham5y

From the WHO report on China, most infection clusters they found were family clusters. This may be applicable to your thinking on this.

4jimrandomh5y

Something is weird about that 3-10% secondary attack rate number. The study isn't published yet, so I don't know what exactly they're measuring, but I'm pretty confident that people who share a household and hug each other will transmit at much greater than 10% probability.

6gwillen5y

This is a fairly late update, but closing the loop on this: I believe the 3-10% number ended up being the secondary attack rate among households where the infected person was isolated after diagnosis. So that's an estimate of the rate of transmission during extended close contact before symptoms/diagnosis, not after, which makes more sense. I assume that extended close contact with a symptomatic infected person will result in very likely transmission.

2gwillen5y

Keep in mind that there may be substantial variation in the amount of viral shedding for infected people (there are superspreaders, presumably there are also subspreaders), as well as in the susceptibility of people to the virus (presumably there is some cross-immunity for people who have had a coronavirus-type common cold recently, for example.) So the transmission rate among household members can't necessarily be estimated from the per-contact rate assuming each contact is an independent chance of transmission.

[-]Isnasene5y90

[Epistemic Status: It's easy to be fooled by randomness in the coronavirus data but the data and narrative below make sense to me. Overall, I'm about 70% confident in the actual claim. ]

Iran's recent worldometer data serves case study demonstrating relationship between sufficient testing and case-fatality rate. After a 16 day long plateau (Mar 06-22) in daily new cases which may have seemed reassuring, we've seen five days (Mar 24-28) of roughly linear rise. We could anticipate this by noticing that in a similar time frame (Mar 07-19),... (read more)

[-]DanielFilan5y90

Metaculus has extended the Li Wenliang prize series - win $$$ as well as internet points by forecasting the course of the COVID-19 pandemic!

4DanielFilan5y

And the prize money for the second installment has increased since I wrote this comment!

[-]Ben Pace5y80

Today will always be the day that, for one hour, Facebook removed all posts/comments that had links to any of The Atlantic, Medium, and LessWrong. Because we're just that big and important.

(The issue is now fixed.)

[-]PeterMcCluskey5y80

Here's some perspective on U.S. stock market reactions to bad news (of nonfinancial origins):

1918 Spanish Flu: -10% in slightly over 5 weeks?
1940 Fall of France: -25% in slightly over 2 weeks
1942 Pearl Harbor: -11% in slightly over 3 weeks
2001 9/11: -12% in less than 2 weeks
2020 COVID-19: -26% in 3 weeks (so far?)

These numbers are based on closing values for the S&P500 (for 1918: the DJIA), from the day before the obvious start of the crash, to an obvious low point where it stabilized. Note that the reaction to the 1918 flu is confusing, maybe

... (read more)

5maia5y

Complete speculation here: Our economy in 1918 was based much more on agriculture and industry, whereas now it is much more based on services, aka people going to work, which they now can't do, and also much larger. So perhaps the coronavirus will, in fact, destroy more real value than the Spanish flu was able to, even as a percentage of the market.

2romeostevensit5y

>Maybe the U.S. and European markets had reflected a much safer world than anyone at the time of prior disasters had expected? that's part of what super low rates/yield imply right? That people expect a very stable world. Higher multiples are flimsier in the face of new evidence.

2FactorialCode5y

There are probably many factors that make this different now than before. However, I suspect that markets today are just smarter than back then. As a result, they react much quicker to information than before. I don't think you can estimate the drop magnitude by the looking solely at the rate of decrease.

[-]SoerenMind5y*80

1/13 people have Asthma. How much worse off are we?

4SoerenMind5y

Data point: There were no asthma patients among a group of 140 hospitalized COVID-19 cases in Wuhan. But nobody had other allergic diseases either. No hay fever? Seems curious.

9jefftk5y

Allergies and asthma are rare in China and other poorer countries. The standard explanation I'vev head is https://en.wikipedia.org/wiki/Hygiene_hypothesis

7Elizabeth5y

That group also was only 1.4% smoker, while china-normal in 2015 was 27.7% (almost all of whom were men). I wonder if people worried they'd get worse care if they admitted to respiratory co-morbidities?

1SoerenMind5y

Right now I expect they just used hospital admission forms. If I was self-reporting 5 pages of medical history while I'm critically ill I'd probably skip some fields. Interesting that they did find high rates of diabetes etc though.

[-]Chris S5y*80

Here's a credible-seeming claim from a computational biologist that, if COVID-19 is like other coronaviruses, long term immunity is unlikely. I imagine this also means a vaccine is unlikely.

If true, this changes everything. Does this mean we are all going to be working from home for the rest of our lives? Or will we accept a world where there is an endemic disease that we get for 3 weeks every year?

4gwillen5y

I think this doesn't quite change everything, for the following reasons: * Even if long-term immunity is unlikely, short-term immunity will push this back towards the flu category, where most people are not getting it acutely at the same time. This will significantly improve the healthcare situation vs what we're seeing in the pandemic phase. * Diseases evolve towards increased spread, which usually involves evolving towards reduced lethality / severity. If this becomes endemic it's likely to do the same. * If it turns out that this does become a severe endemic disease, there will be a lot of pressure on the development of a vaccine, much more so than has been true for human coronaviruses in the past (when they were much closer to being mostly a nuisance, and included in the general "common cold" category.) Even if long-term immunity is unlikely, we can still improve the situation like we currently do with influenza, giving people periodic boosters based on the current circulating strains.

7Chris Hibbert5y

Diseases normally evolve toward increased spread by reducing lethality because they don't have a superpower like Covid2019's ability to spread while the carrier is asymptomatic. I don't think there's much evolutionary pressure on this disease toward lower severity. Even if we do a good job of enforcing shelter-in-place in populous areas, there will be hidden reservoirs until we reduce the number of new cases in connected communities all the way to zero. The normal evolutionary pressure works because there's some variation between different strains, and whichever variant can reach the most people comes to dominate. With a normal infection, once everyone is aware, you can quarantine people with evident symptoms and thus squelch the spread. Any variant that has milder symptoms has a better chance of spreading and becoming dominant. Covid2019 already has the ability to escape surveillance if there's any of it in the population, so a less lethal variant doesn't have a selective advantage.

5Elizabeth5y

My understanding is that asymptomatic spread is pretty common.

4Chris S5y

That's a good answer, and consistent with this very good article by Johns Hopkins epidemiologist Justin Lessler. He makes many of the same points you make, and adds that there will likely also be partial immunity even within individuals. (At least, I suppose, if we aren't facing antibody-dependent enhancement.)

[-]gwillen5y80

A friend of mine (who lives in the SF Bay Area, currently somewhat of a coronavirus hotspot) posted to Facebook that he hasn't been feeling well recently and he thinks he might be sick (and was having trouble focusing at work yesterday). I posted the following; I don't know him well enough to know how he'll take it, but we'll see. I feel like we're still at a point on the curve where this kind of individual outreach can potentially have substantial value, so I'm offering it as perhaps a template for other people to use.

Yikes, good luck -- I hope you feel

... (read more)

[-]Eli Tyre5y80

Does anyone have updated figures on the fatality rate for different age groups, compared to the ones posted in this comment?

I imagine that that table is mostly based on data from the early outbreak in China, which may or may not generalize well to say, my parents.

1Christoph Richter5y

https://www.tableau.com/about/blog/2020/3/covid-19-resources-data-viz-best-practices This provides a more detailed overview of the china data. Specially, most patients have been ill before. As Cadiovascular conditions mostly are with elderly persons this makes them a high risk group.

[-]ignoranceprior5y70

Questions about buying chloroquine:

1. Is it better to buy hydroxychloroquine or regular chloroquine? The studies I've found suggest hydroxychloroquine is safer and more potent, but it is a bit more expensive.

2. How many days worth of the drug is it reasonable to buy per person?

3. How much should someone take per day and how should the dosage be timed?

4. Can someone confirm that the products you can find on reliablerxpharmacy.com when searching for "Lariago" (500 mg chloroquine as phos) and "OXCQ" (200 mg Hydroxychloroquine Sulfate) are the right things to buy? If not, is there any other reputable or semi-reputable source that sells the right product?

2johnlawrenceaspden5y

That's the right stuff I think (chloroquine phosphate, very bitter tasting), would you say that reliablerxpharmacy is a good and trustworthy source? (not for chloroquine, for meds generally without a prescription)

[-]TobyBartels5y70

Hi, I haven’t posted in a while, and I hope that people are still reading new comments in this thread, because I need an answer fast, and this is the best place that I know to get a good one. (Well, second best. I posted to SSC first.)

My parents, age 70, live in Lincoln NE (population 285 thousand, no reported cases of Covid-19 yet, 17 reported cases in the State, schools just closed and are preparing to go online). They pretty much run their bridge club, most of whose members are in their 70s but generally in good health. The club has an event planned f

... (read more)

9Elizabeth5y

Here is what I wrote my dad in attempt to get him to close up the church of which he is an elder, in a similarly sized city. My dad is a statistician and 30% prepper, so this was more about giving him evidence to take to others than convincing him: I didn't think of this at the time, but in retrospect it would have been helpful to suggest replacements for an in-person service. I'll bet it is easier to convince your parents' friends to switch to online bridge with voice chat than to give it up entirely.

4TobyBartels5y

I have good news and bad news. The bad news is that the game went on last night as planned. The good news is that my parents won't be attending any more large games. The bad news is that there are still going to be more large games, at least one tonight. Although it's mostly the same population every time.

[-]TobyBartels5y160

The club is now closed until further notice.

4Elizabeth5y

Asked a general version of the question here

4TobyBartels5y

Previous versions of this question: https://slatestarcodex.com/2020/03/11/open-thread-149-25/#comment-865412 https://slatestarcodex.com/2020/03/15/open-thread-149-5/#comment-865535

[-]Bucky5y70

I have created the top two graphs of my previous post on outbreak speeds as interactive versions here (thanks to Ruby for helping with getting this uploaded). The labels on the right are clickable to remove or add countries (double click selects only that country or all countries). The buttons at the top change the y-axis (annoyingly the y-axis range buttons auto-set to a linear scale) and the slider at the bottom zooms the x-axis.

[-]MaxCarpendale5y70

We started an effective altruist coronavirus discussion group on Facebook and there are a lot of posts in it. The link is here if you're interested.

[-]James_Miller5y70

From a friend who is a microbiologist Phd "Oh and drink plenty of water. My lab group discovered that humans and cows partially rid their body of viruses (at least adenovirus) through their urine. "

4romeostevensit5y

It also apparently helps with lessening the spread from the mouth/throat to the respiratory tract making it more likely to stay mild.

[-]Raemon5y70

I recommend people write covid-19 things here rather than in shortform, because soon we'll have tagging properly implemented for posts, but not for shortform, and it'll be easier to find all coronavirus related commentary if it's here.

[-]jimmy5y60

The one situation where an entire, closed population was tested was the Diamond Princess cruise ship and its quarantine passengers. The case fatality rate there was 1.0%, but this was a largely elderly population, in which the death rate from Covid-19 is much higher.

Projecting the Diamond Princess mortality rate onto the age structure of the U.S. population, the death rate among people infected with Covid-19 would be 0.125%.

John Ioannidis is making an interesting (and reassuring, if true) claim here. Has anyone looked at the demographics and done the compa... (read more)

[-]Lukas_Gloor5y*180

This can't be right. I've looked into Diamond cruise studies and some stay at 1% even after adjusting for age (they factor in that more people might have died in the meantime – even though that didn't happen so far, admittedly – and the unadjusted number is 1% at least already; makes you wonder whether elderly cruise goers are healthier than their stay-at-home cohorts). I've found this study which, after doing some adjustment steps I don't understand but find dubious (maybe they double adjusted something by accident?), ends up estimating 0.5% for China's total outbreak. You might think this makes the 0.125% figure mentioned by Joannidis somewhat plausible, because China's outbreak had a majority of cases in Hubei where patients didn't all have access to hospital care. This is likely to drive up the fatality rate. However, the study didn't account for that. They just implicitly assumed that people who got sick on the cruise ship had the same prospects as people who got sick in China. And they may or may not have halved their estimates in some dubious way too. So, 0.5% seems like an absolute lower bound here, and more li... (read more)

3jimmy5y

Yeah, the 1/8th multiplier sounded hard to believe. A 1/2 multiplier based on demographic correction sounds a lot more plausible, and it's nice to have confirmation that someone else actually did the math. Thanks for finding/sharing it!

3Lukas_Gloor5y

I should flag that I didn't do the math for age correction. I only got this from another Diamond cruise study where the age correction provided a smaller update (and I didn't really like other things about that study). So, I think it could be valuable to investigate this claim more: (But even if this point was right, there's still South Korea to explain.)

3Lukas_Gloor5y

Reading the Ioannidis article, it seems to say that he did his own calculations, and he doesn't show them. Okay. I'm curious about this, so I'm going to try a ballparking estimate myself. Tl;dr I intially arrived at a result that suggested 0.125% was way off, but then found better info on the cruise ship's age distribution and had to revise my judgment. I now find it debatable whether 0.125% is defensible or not, but it's not "way off." My own estimate would be more in the ballpark of 0.3%, but I don't anymore consider the cruise ship to be evidence for IFR estimates at 0.5% or higher. Update March 24th: In the couple of days, 3 new patients who had tested positive on the Diamond Princess have died. In addition, the Wikipedia article has been edited to list another death that previously hadn't been included. So total deaths per confirmed cases on the Diamond Princess are now 11 / 700 instead of 7 / 700. All my calculations below are based on the older, outdated numbers. To get the most updated estimates, just multiply the results below by 11/7. --- Note that I have never done age adjustments for anything, so I have no idea what the proper methdology would be. I'm just curious to see if 0.125% is potentially reasonable rather than (as my current intuition suggests) very dubious. From this paper, I found the following info: At the end of the outbreak, roughly 700 people had tested positive. I'm going to assume that the 66 patients not yet in the above statistics fall into age categories in the same proportion. So a bit more than two thirds of the 66 patients get added to the 476 figure for people aged 60 and older. With this adjustment, we have 700 diagnosed cases, of which an estimated 525 patients were aged 60 and older. Of those 700 diagnosed cases, 7 people died. 525 out of 700 corresponds to 75%. (I'm going to mostly ignore the death risk for people below age 60 for the analysis below, because it will be negligible given that people older than that anyway

1ErickBall5y

You found an age distribution for the infected population on the Diamond Princess, but you're using it as if it's the age distribution for everyone on the ship. Older people are more likely to get infected, so the infected population in the US will lean older as well--closer to the distribution on the ship. To do a good age adjustment we need to know the ages of the people on the ship who were not infected.

1Lukas_Gloor5y

Interesting! Do you think this is established? I haven't looked into this, but my guess would have been that the risk is similar because young people are less scared of the virus. But yeah, good point about further adjustments being needed to get the best estimate.

2ErickBall5y

Hmm, maybe you're right. The South Korean distribution of cases by age here suggests that it's actually most common by far among people in their twenties, and the larger number of confirmed cases among older people is a statistical artifact resulting from test criteria. The data do look a bit suspicious though.

3jimmy5y

Right, I got that it was them doing the math correction not you. Still, they did the math and give an age breakdown of the passengers and a crude sanity check gives a number within about 30% of what they report.

7Roko5y

I don't think the view in that piece here is consistent with what happened in Lombardia in Italy, but I haven't seen a detailed numerical argument against it.

9Lukas_Gloor5y

I also thought that in Lombardia, the estimates given by Ioannidis are rapidly trending toward coming in contradiction with SIR models. :( Lombardia has a population of 11 million people and 2,500 reported deaths. Some doctors are raising alarm that many deaths are going undetected because people are dying at a rate that's 4 times higher than the same month last year. In addition, the death counts always lags behind because some people are sick for a long time before they die (though maybe this start to be the case less strongly in conditions of extreme hospital overstrain). All of this suggests that an estimate of 10,000 deaths for Lombardia alone might soon prove to be accurate. But according to the IFR provided by Ioannidis, this would correspond to an expected 8 million people infected (72% of the population). I don't understand SIR models well enough to calculate what the R0 would have to be for 72% of a population to get infected. I suspect that Covid-19's R0 is high enough to be consistent with this, but it wouldn't leave a lot of room for estimation errors. That said, I think the above calculation is naive, so the argument doesn't work (at least not in this crude form). If hospitals become as overwhelmed as they are in Italy, I'm sure that even someone with Ioannidis' view would expect the IFR for Lombardy to become a lot higher than 0.125% because a lot of people aren't getting life-saving hospital attention. So, this means that Lombardy isn't necessarily a knockdown argument against Ioannidis's estimate in the same way South Korea is. However, I think Ioannidis's estimate would have counterintuitive implications for the percentage of people infected in Lombardy. It would have to be in the double digits already at the very least. The most trustworthy estimate I saw about Wuhan suggested that only 5% of its population had the virus. However, there's some disagreement about this, and the people who tend to argue for an unusually low IFR also tend to argue t

[-]qirlib5y60

Does this thread welcome asking for highly personalized advice? I'm stuck with a few possible action options and the explanation is quite lengthy and the answers will probably be relevant to very few. I can't decide whether this thread is only about posting globally useful things or not.

6Elizabeth5y

That would be discouraged in a top level post but is exactly the kind of thing this post is for.

4Raemon5y

Oddly specific advice is fine.

[-]RedMan5y60

In the usa, much of the workforce is paycheck to paycheck and does not have paid leave or short term disability, and health issues are a common cause for bankruptcy. So the following is applicable to a lot of people who probably are not in this (rationalist/lesswrong) community:

If you don't work, you don't get paid, so you don't make rent. If you get quarantined by the state after a positive test, you don't go to work, you don't get paid, and you don't make rent. If you don't make rent, you probably will not have a place to live. If you end up in the h

... (read more)

[-]James_Miller5y60

I have been taking NAC (n-acetylcysteine) as a supplement for a while. You can (still) buy it on Amazon. From an Elsevier press release "The authors draw attention to several randomized clinical studies in humans that have found that over the counter supplements such as n-acetylcysteine (NAC), which is used to treat acetaminophen poisoning and is also used as a mucus thinner to help reduce bronchitis exacerbations, and elderberry extracts, have evidence for shortening the duration of influenza by about two to four days and reducing the se... (read more)

[-]Raemon5y60

I'm particularly interested in people sharing models / spreadsheets that they're currently working through here. (Posting them as top level posts is also fine, but I thought it might be good to encourage more "thinking out loud" in quantitative ways, even while you're still fleshing a model out and still have a lot of open questions about it)

9rocurley5y

Here's my bay area hospital capacity model: https://www.getguesstimate.com/models/15278

5Pablo5y

Here's a basic SIR model created by Metaculus user Isinlor. (I haven't looked at it, so don't interpret this comment as an endorsement.)

4Pablo5y

Buck's tentative Guesstimate model of Wei Dai's "hospital crowding" catastrophic scenario. Many folks have already seen his comment, but I'm posting a link to it for completeness.

4Pablo5y

Daniel Filan's Guesstimate model on whether he should stay home for work. Many folks have already seen his comment, but I'm posting a link to it for completeness.

3Lukas Trötzmüller5y

When to cancel events due to Coronavirus? Calculations by Linch Zhang [1], I've put them into a Guesstimate with some slight changes and adaptions for Austria [2] [1] https://docs.google.com/document/d/1A0jcxj4n0BvNt_jMunHT5WSsAKFzuVJJyaaqcK9Z1HU/edit# [2] https://www.getguesstimate.com/models/15367

3Lukas Trötzmüller5y

Dating during Coronavirus: What's the risk of going on a date with a random new person at the height of an outbreak? https://www.getguesstimate.com/models/15381 Under my assumptions, if 1 in 7700 people gets newly infected every day, it translates to an infection risk of 0.2% per encounter (range of 0.45% - 0.053%). Feedback welcome.

3Tobias H5y

Here's a tool to estimate how badly hospitals will be overfilled in your community. http://scratch.neherlab.org/ It's by Richard Neher and colleagues and an early stage tool. Might nevertheless be interesting to play around with. Here's the source and some explanations about the underlying model: https://twitter.com/richardneher/status/1236980631789359104

3ErickBall5y

Unfortunately it doesn't let you modify the assumptions about disease severity or number of undetected cases. It assumes that the majority of cases have been undetected (which seems questionable) and that 4.31% of cases are severe (which seems low even if the majority are undetected). It gives a case fatality rate of 0.97%, which doesn't seem to depend on any of the other parameters. In their baseline scenario (for a small Swiss city with good infection control) 0.26% of the population dies. With no infection control this goes up to 0.76% of the population dying, with no change in the CFR. If you also increase the length of a hospital stay from 10 days to 20 days, the total number of deaths actually decreases slightly because the spread is slower. So while the graph is a nice way to see how long hospitals will be overwhelmed in different scenarios, it doesn't show you anything useful about how this affects outcomes. I would love to be able to add in some parameters for fatality rate for severe and critical cases with/without a hospital bed.

6cousin_it5y

Sad laugh. I'm in Switzerland, we have exponential growth and there's no infection control to speak of. They just told people with non-severe symptoms to not bother getting tested. Schools are open. Haven't seen even one person wearing a mask.

2Pablo5y

Another basic SIR model, which considers impacts on hospital capacity (and resulting deaths) from infection controls of various degrees.

2Eli Tyre5y

Coronavirus automatic tracking and population modeling v.2

2Pablo5y

The Medium article that Wei Dai cited in his comment links to an "open-source model". I haven't examined it closely, though I did notice that some of the formulas are weirdly constructed (e.g. using INDIRECT rather than absolute cell references) and that some of the assumed parameters are overly pessimistic (e.g. a 3.4% CFR).

[-]Steven Byrnes5y50

I'm still pondering the implications of transmission being mainly about air, not touching. What interventions does that suggest? Besides the obvious things (opening windows, HVAC filters etc, masks & goggles), one thing I thought of is ... perfume!

We could all encourage everyone to wear perfume / cologne when they leave their home, and if anyone can smell anyone else, then they know you're not sufficiently well physically-distanced (too close or not enough air circulation).

Assuming this would work, I'm not sure how to get it to take off. Maybe an unusu

... (read more)

[-]Wei Dai5y50

Suppose one of the drugs under investigation for COVID-19 effectively reduces its morbidity and mortality. For simplicity let's say that it quickly and completely cures 90% (or X%) of patients but does nothing to the remaining 10%, and we manage to scale up manufacturing enough to be able to treat everyone with the drug. Would the major developed countries then decide to relax the current mitigation/suppression policies and let the pandemic run its course (thereby accepting the morbidity/mortality of the refractory 10%) in order to revive their economies? What do you think the threshold for X would be for the major developed countries to do this?

2romeostevensit5y

I feel like there's wet spaghetti code at both ends of this? On one side we have economic impact projections that vary about an order of magnitude and the other we have expected death projections that vary over 1-2 orders of magnitude.

[-]madhatter5y50

Someone on Hacker News had the idea of putting COVID patients on an airplane to increase air pressure (which is part of how ventilators work, due to Fick's law of diffusion).

Could this genuinely work?

2Chris Hibbert5y

Airplanes pressurize to levels that aren't as high pressure as being on the ground, I'm pretty sure. They're trying to reduce the consequences of being at altitude, not increase above sea level.

[-]DanielFilan5y50

The New York Times heavily implies that many sick package delivery workers are feeling pressured to show up to work despite their illness.

[-]FactorialCode5y50

A sneak peak at the coming economic impact:

Google trends: How to file for unemployment.

https://trends.google.com/trends/explore?date=today 3-m&geo=US&q=how to file unemployment

[-]Joel Chan5y50

Many have probably seen the threads (e.g., here and here, and this Medium post by Yishan Wong) about how massively scaled up testing is the key to threading the needle between economic collapse (long-term suppression tactics) and unacceptably high mortality (mitigation only, or worse, doing nothing). Aggressive and scaled up testing infrastructure is the key enabler for contact tracing, which appears to be the cornerstone of the South Korea model, which notably does not rely on draconian suppression tactics like lockdown, and they are currently the only ot... (read more)

[-]sprague5y50

Is somebody keeping track of the "what if we're wrong and it turns out this is another Y2K" scenario? Social distancing, closing borders, heightened awareness and preventative measures -- seems like a lot is happening that could make this way less scary, at least in the US, than most of the mainstream scenarios.

I'm not interested in the hearing from denier-types who think this is "just another flu", but rather the thoughtful people who have specific testable predictions that would demonstrate this is more social contagion than most of us suspect.

9Vaniver5y

That is, a combination of "prevention work successfully means no big disasters" and "absence of prevention work doesn't cause any major disasters"? I think that cat is already out of the bag on the latter one; people might end up disagreeing on whether it was better to be in Iran or Wuhan, but they won't be able to disagree that the lockdown in Wuhan had an effect. I think there will be variation in what sorts of social distancing happen, which we should be able to back out data on, and similarly demonstrate that social distancing had an effect. (I expect it'll be smaller than many people hope it'll be, but it'll still be noticeable.) Like, we could see the effect in 1918 influenza data, and we have a much better ability now to track how people come into contact with each other. [I expect the main thing to happen is that people take insufficient protective measures, which makes them look like a waste, or we get stuff like "ah look, extensive social distancing meant the peak happened two weeks later!", which is of unclear value compared to the costs.]

-1sprague5y

Those arguments make sense, but for example what if despite our best modeling, the cases just start to decline and then the whole thing just disappears in a month? At what point would we have to seriously re-evaluate everything we know about this virus? Say new cases plunge 90% next week? 50%? Scenario planners try to think of every possible alternative, including those that seem far-fetched. I'm trying to figure out what the positive alternatives would look like.

[-]Vaniver5y250

From A Technical Explanation of Technical Explanation:

How would I explain the event of my left arm being replaced by a blue tentacle? The answer is that I wouldn’t. It isn’t going to happen.

If a miracle happens, then a miracle happens. I'm not holding my breath.

The ways in which I do expect Vaniver_2021 to look back at Vaniver_2020 and think "yeah, he was worried about that but it didn't turn out to be relevant" are various unknowns about the virus that might be fine or might be bad. For example, we don't know how bad surface transmission will be, but that's a big factor in what sort of isolation protocols you need to have. We don't know whether existing anti-virals will be effective. We don't know how long immunity will last, but that's a big factor in whether or not 'herd immunity' strategies will work, and how valuable it is to not catch it. We don't know how big a deal antibody-dependent enhancement will be, or how that will interact with the duration of immunity. We don't know what long-term effects of infection (think fatigue, disability, infertility, etc.) look like. We don't know how long people are infectious before they show noticeable symptoms.

For all of those things, I

... (read more)

6TobyBartels5y

I thought that we were right about Y2K, people spent a lot of time preparing for it, and their hard work saved us all. Is that wrong? (I understand if you just link to somewhere else and don't clutter up your thread any further with this digression.)

4Vaniver5y

According to some as summarized by wikipedia, there's not all that much evidence that people who didn't prepare were bitten by it, or that fixing ahead of time was cheaper / better than fix-on-failure.

1sprague5y

I mean Y2K in the sense of lots of fretting about something that turns out not to happen, whether because of significant preparation or from just being wrong about the urgency. I realize it doesn't seem likely, but in the spirit of humility before humanity's collective ignorance, how might we know we were wrong? Like, clearly nobody's expecting US cases to suddenly level off and then disappear, but what if that happens anyway? At what point would we say we were just totally wrong?

[-]ErickBall5y50

Ohio health official estimates 100,000 people in state have coronavirus:

https://thehill.com/policy/healthcare/487329-ohio-health-official-estimates-100000-people-in-state-have-coronavirus

This sounds crazy, but I don't understand the methodology so I'm not sure... Do people think it's plausible?

[-]Elizabeth5y100

I can't rule it out, but it doesn't sound like this estimate was arrived at through sound practice.

8ErickBall5y

Follow-up: Trevor Bedford has also debunked the claim in this twitter thread, saying that by the time Wuhan had 100,000 infections there were 1000 severe cases and 300 deaths. For Ohio to be in that state now the disease would have had to be spreading there since about mid-December.

6Michael McLaren5y

This ^...Another way to spot check the "100000 cases" estimate without knowing the Wuhan numbers is to consider that that would imply roughly 1e5 / (2^4) = 6250 cases 3 weeks ago (the typical delay between infection and death; assuming 6 day doubling time), which corresponds to 31-125 deaths by today for a case fatality rate in the interval of [0.005, 0.02]. That would be for Ohio alone. As of March 13, the US CDC is only reporting 36 deaths for the country as a whole (source; though reported as 47 deaths here) and Ohio is currently reporting 0 deaths (source). Not to say that this is a definitive argument against there being 100000 cases in Ohio, but it does suggest that this estimate wasn't based on current understanding of the virus and its spread. Update: On March 13 Trevor Bedford also tweeted a rough estimate of 10K-40K cases nationally.

4gwillen5y

I hope that there is some actual epidemiology going on behind the scenes here that is being oversimplified for the press, but there's nothing in the article to really indicate that the estimate has anything meaningful behind it...

3Davis_Kingsley5y

I believe it's obviously wrong and the stated methodology makes no sense. The fact that community transmission is occurring does not by any means mean that 1% of the population is affected. It's possible there's some other information that justifies this but I would be *extremely* surprised if it were actually the case that 100k people are infected in Ohio right now.

3Bird Concept5y

If this was the case it ought to be visible indirectly through its effect on Ohio's healthcare system. I haven't heard of such reports (and I do follow the situation fairly closely), but I haven't looked for them either.

1Lennard Iosif5y

Adding to this - what impact would this have on Wei Dai's estimates on mortality rates skyrocketing if health systems are overburdened? If significant portions of the population already have the illness, then would that imply a significantly lower mortality rate than expected? Or could this simply be a leading indicator that we are closer to the peak than we originally thought?

[-]AlexSchell5y50

How should I disinfect objects with complex surfaces (e.g. box cutters, door knobs) if I don't have access to alcohol? Is brushing with soap likely to be sufficient or should one just avoid touching these objects for a few days if they're possibly contaminated?

3Original_Seeing5y

https://www.journalofhospitalinfection.com/article/S0195-6701(20)30046-3/fulltext#sec3.1 lists a lot of different disinfectants. 3-4 is decent. 4+ is good. Do you have any disinfectants at all?

3AlexSchell5y

Thanks! I didn't realize how effective bleach is. I recently moved and didn't get around to stocking up on any alcohol until it was out of stock in most places. I am expecting a shipment of industrial ethanol (still available, just don't ingest/get on your skin) but the bleach will arrive sooner. Thanks again.

1Original_Seeing5y

Depends on what kind of bleach it is, but many chemicals commonly called bleaches are very strong. Hydrogen Peroxide is broad-spectrum and very effective.

4AlexSchell5y

I meant sodium hypochlorite

6jefftk5y

I wrote something looking into bleach: https://www.lesswrong.com/posts/QJfiKwicwTXYMzJ7q/bleach Summary: it's extremely concentrated, and a highly recommended disinfectant, but it's also dangerous and you need to be careful with it in specific ways

[-]rmoehn5y50

How about an app that trains you not to touch your face?

Point your phone's camera or a webcam at yourself while you're working. The app produces a beep whenever you move your hand near your face.

Technically feasible, I'd say. Someone familiar with iOS/Android computer vision APIs should be able to put it together in a few days.

[-]Elizabeth5y120

It exists.

2Raemon5y

OMG this is amazing.

2Raemon5y

Geez it makes my CPU freak out tho.

1rmoehn5y

Splendid!

[-]Shmi5y50

I wish I didn't have to see the deluge of coronaposts in my feed or under Latest Posts.

4Ben Pace5y

One of the reasons this thread exists is for that content to go here instead :)

4Raemon5y

Yeah. We're working on a tag filter, hopefully will be ready soon.

[-]Alexei5y40

My wife's doctor said chloroquine (a treatment for malaria) was shown to be very promising in treating COVID-19. I guess it's public now as well: https://www.wired.com/story/an-old-malaria-drug-may-fight-covid-19-and-silicon-valleys-into-it/

3zby5y

This is interesting subject - can we do here better than official science? As I understand the situation now there are still no good trials on this. There is one Italian trial that was heavily criticized: https://news.ycombinator.com/item?id=22662103 , and one Chinese that has not been published yet: http://www.chictr.org.cn/showprojen.aspx?proj=48880 - and some older ones for SARS https://www.ncbi.nlm.nih.gov/pubmed/15351731?dopt=Abstract But maybe soon we'll have better data: https://www.sciencemag.org/news/2020/03/who-launches-global-megatrial-four-most-promising-coronavirus-treatments I think official science should be pretty good on this one unless we find some mismatching incentives like in Inadequate Equilibria

[-]romeostevensit5y40

Subway use in New York is only down 20%. And mask use is rare. How is NY not completely screwed?

2romeostevensit5y

update: https://www.governor.ny.gov/news/governor-cuomo-signs-executive-order-mandating-businesses-require-office-personnel-decrease He's still basically claiming over reaction but at least this is something major.

[-]DanielFilan5y40

How much should COVID-19 update me about the risks from pandemics?

5Kaj_Sotala5y

That probably depends on what your pre-COVID-19 model was? If I rephrase the question as "how much should COVID-19 update expert models about risks from pandemics", then my impression is that things have proceeded roughly in line with the pre-existing models. The response procedures that are now being activated in several countries are based on plans that were originally made as a reaction to previous diseases such as SARS. My own update is that although there has been some feet-dragging, overall the national responses have felt stronger and faster than I would have anticipated. The next time that there is a pandemic, such a response should hopefully be more routine and competent, so this makes me more optimistic about our ability to deal with future pandemics.

2ChristianKl5y

LessWrong censi did frequently list pandemics as concern for the annihilation of the human race for many participants. To me this episode suggests that as a group we were right to be more concerned then the average person on the street. I would expect the crisis to increase public funding of pandemic intervention a lot, so the objective risk will go down in comparison towards pre-COVID-19. I think it makes sense to go from the previous majority opinion that pandemics are the biggest x-risk to consider AI risk the biggest x-risk with pandemics at the second place.

4DanielFilan5y

Presumably COVID-19 should update me on natural pandemics happening more frequently than I would have otherwise thought though, right?

2ChristianKl5y

Of course it's Bayesian evidence for natural pandemics happening more frequently, but the size of the update depends on your previous model. People who think that climate change is a more serious threat then pandemics should likely update towards pandemics being more serious but I don't think that includes most of our community. There's a chance that calling this a natural pandemic in the way an earthquake or a supervulano eruption is natural is also misleading. There's a good chance that this pandemic was acciendently created by the human institution of a wild animal market in China. Xi's China seems authoritarian enough to shut down those markets in the future. Our preparedness towards pandemics was really screwed up. This cricis will affect the public psychy like 9/11 and we will do a lot to get future safety.

[-]Ben Pace5y40

I thought I'd share the steps my housemates and I have taken to be safe from the coronavirus, just to spread info about what people are doing. I'd be interested in others saying some things that they've done. This isn't exhaustive, I've almost certainly forgotten some things. (Note that we live in Berkeley, California, US.)

We don't meet anyone from outside the house / go to work / go shopping, and generally stay in the house/garden. Some housemates take walks / go for a run, keeping 6 feet away from people at all times.
If anyone thinks there's a need to le

... (read more)

[-]K2msmith5y40

Write or message your local county public health department to include a history of the number of new cases per day not just the current total on their covid-19 website. Growth rate is just as important as the current state.

1Chris Hibbert5y

I've been following the daily numbers from California, Washington state, and New York, on covid2019.app, which were extremely informative, but they stopped reporting by state as of two days ago. Anyone know of a good source for daily state level new case data? Summary: CA, WA, and NY had all reached 100 reported daily new cases by 3/14. Up to 3/19, neither CA, nor WA had broken through 200 new cases, but on 3/18, NY reported 1709 new cases, and on 3/19 they had 1069. The state level data is not available at the moment (when the site was working better, it said state level would be available), and even the regional data is broken in the current download.

3PeterMcCluskey5y

I use https://en.wikipedia.org/wiki/Template:2019–20_coronavirus_pandemic_data/United_States_medical_cases

4Chris Hibbert5y

Thanks, Peter! very helpful. Update on the data: NY is now adding 5000 new cases per day. WA is above 200, and CA above 250. No one looks like they're stopped the growth in new cases. A slow exponential is still exponential.

4Unnamed5y

Keep in mind that the trend in the number of confirmed cases only provides hints about the trend in new infections. The number of confirmed cases is highly dependent on the amount of testing, and increases in testing capacity will tend to lead to more confirmed cases. Also, there is a substantial delay between when a person is infected and when they test positive, typically somewhere in the range of 1-2 weeks (with the length of the delay also depending on the testing regime).

[-]DanielFilan5y40

Anybody know the rough cost-benefit tradeoff of donating blood products a doubling or two from now? [EDIT: this place is not packed, but there are people there, and I'm obviously in contact with the nurses]

[-]Chris Hibbert5y120

The donor centers are probably the cleanest place you can visit outside an ICU. Their standard hygiene practices are superb and have been so since the HIV epidemic decades ago. (I've been giving blood routinely for at least 35 years.) Even if someone were to visit who had been exposed, there's little chance they could transfer it to anything that would transfer it to you. The one opportunity you have to be close to other people who aren't being extremely cautious at all times is in the canteen for your mandatory 20 minute break after donating, and unless the donor center is extremely crowded, you'll be able to maintain a 6 foot separation and not touch anything that isn't freshly removed from packaging for your use.

I donated platelets a week ago. I stopped donating whole blood ~ a year ago after noticing that it impacted my ability to exercise (blood oxygenation, presumably) for a few weeks after donating. Now that I'm sheltering-in-place and not getting any of my usual aerobic exercise, I'm considering giving whole blood once I've passed the waiting period.

[-]Alexander Mont5y40

I'm currently in an apartment in Washington, DC living with one other family member. I have decided that I want to self-quarantine completely (i.e. no leaving the apartment, deliveries only), and the other person is saying that they are willing to mostly quarantine (i.e. work from home, no trips to the store, etc.) but they aren't willing to refuse to go outside.- they want some fresh air. Is there a good way of modeling the risk associated with just going outside and walking around? And of the family member then giving it to me? I do have anothe... (read more)

[-]habryka5y130

At our group house we decided that going out on walks is fine, as long as you stay more than 6-feet away from people. I am not sure whether that's feasible where you are, where we are it's feasible, but only at times of the day that tend to have less people around.

3Raemon5y

One house is doing group "night runs" where they go out jogging together at midnight.

1Chris Hibbert5y

Going outside for solo exercise (walking, jogging, Tai Chi) is pretty safe. I'm not absolutely positive that tennis or volleyball (multi-player sports, but with shared contact with the ball) or ultimate frisbee or basketball (close proximity, occasional contact) are as safe. The SF Bay area shelter in place order encouraged going on walks or hiking, and that seems sensible to me.

[-]Unnamed5y40

Here's a method to try to estimate the number of cases in a region which I haven't seen calculations of:

1. Identify the places which have the best testing regimes

2. Try to estimate what fraction of cases are identified in those places, potentially along with other variables like how long from infection until the case is identified

3. Use those numbers to extrapolate to other places, based on other similarities between those places besides # of confirmed cases (e.g., number of deaths, or rate of infection in travelers coming from that place, or hos... (read more)

2Unnamed5y

This paper looks at cases which were confirmed in Shenzhen (Guangdong, China) Jan 14 - Feb 12, which is while coronavirus was being brought under control there (by the end of the study the cases had fallen to less than 1/3 of their peak). I suspect that they qualify for point 1, a place with an unusually good testing regime. The paper reports that "Cases detected through symptom-based surveillance were confirmed on average 5.5 days (95% CI 5.0, 5.9) after symptom onset (Figure 3, Table S2); compared to 3.2 days (95% CI 2.6,3.7) in those detected by contact-based surveillance", and also that the median incubation period was 4.8 days from infection to symptom onset (in the smaller sample where both of those dates were known). Adding 5.5+4.8, that implies that an average of 10.3 days passed between when a person became infected and when they tested positive for cases detected based on symptoms, and 8.0 days for those detected by contact tracing. Since the paper reports that 77% of cases were detected through symptom-based surveillance, that gives an overall average of 9.8 days. (And this is only for the cases that were detected; it's not adjusting at all for people who were infected by never got a positive test.) That means that in places where testing is as good as it was in Shenzhen, then the number of positive tests is telling us about the number of infections 9.8 days ago. If the number of cases in that region is doubling every 4 days, then that's 2.4 doublings, so the number of confirmed cases would only be 18% of the actual number of cases due to the delay in testing (again, without factoring in people who never got tested). (With a 3 day doubling period it would be 10%, with a 5 day doubling period 26%.) So in places that don't have a good testing regime it would be significantly less than that.

[-]Sherrinford5y40

Here is a summary of an ebook about the economics of the Coronavirus:

http://conversableeconomist.blogspot.com/2020/03/some-coronavirus-economics.html

It also contains this figure:

https://1.bp.blogspot.com/-OZM_DUZq8eI/Xmj2kbpt57I/AAAAAAAAKQ4/Viik1kZDuZEalcQ2zP-yKYVgwcbh1kgZgCLcBGAsYHQ/s400/coronavirus%2B1.jpg

[-]ChristianKl5y40

I have the impression that there are a lot of windows in public transportation that currently aren't opened due to it being cold outside.

It's likely beneficial to get to a state where all the windows in public transportation that can be opened are actually opened.

There might be a high value in pushing that meme as it's an easy intervention.

[-]vidro35y40

Is it anticipated that COVID-19 will have more estimated cases than the seasonal flu? Would appreciate a link to supporting info.

Is R0 the best way of measuring contagiousness?

5justin_dan5y

Someone on Reddit linked to this preprint paper arguing that the other moments of the secondary infection curve (variance, skewness, kurtosis) can overwhelm the mean (i.e., the R0) in predicting the number of people ultimately infected. With a high variance, right-skewed, high kurtosis curve (loosely, with relatively few "super-infectors" bringing up the average), there are more chances for the outbreak to stochastically die out before those super-infectors get their chance to keep things going. The authors conclude that "higher moments of the distribution of secondary cases can lead a disease with a lower R0 to more easily invade a population and to reach a larger final outbreak size than a disease with a higher R0. " I'm not positioned to evaluate all of their arguments, but their reasoning based on the models they provided made sense as far as I could tell, using some assumptions that seemed fairly reasonable to this layperson. The practical consequence of this is that effective contact tracing in the early stages of an outbreak (before too many so-called "community spread" cases) would provide invaluable epidemiological data.

4vidro35y

honestly have no idea what that all means. thanks for trying though.

1justin_dan5y

R0 tells you how many others each person infects on average. So R0 is in one sense the measure of contagiousness--it just tells you how contagious people with the disease are on average. Consider two different diseases with the same R0, let's say R0 = 2. So each person on average infects 2 others. For the first disease, almost all patients infect exactly two others, but for the second, plenty infect two, many infect one, and a much smaller number infect 10 or even more others. So the average is the same, but the distribution is very different. Given some other assumptions, this paper shows that diseases more like disease one will end up infecting many more people in the end than diseases like disease two, even though they have the same R0. So it is important to understand the distribution of secondary infections in addition to the average when predicting the final outbreak size. Contact tracing (seeing who people with the disease came in contact with and checking to see whether they end up getting infected) allows epidemiologists to do that.

4Elizabeth5y

R0 is not a great way of measuring contagiousness. For example, Ebola has an R0 of 1.5-2, and Influenza 1.1, but obviously many more people catch Influenza than Ebola. I don't know if this is the cause of the problem with these particular numbers, but in general, R0 is very much a compound function of disease and environment, and therefor doesn't tell you much about how contagious something will be if you change behavior.

[-]jmh5y30

Two related "wild" ideas, as I think we probably have the basic technology and knowledge but probably not something we can quite do now.

My understanding is that the virus is attacking the ACE2 molecules. These actually form a gateway between the interior of the cell and the external environment.

If so, in theory, we might be able to create a number of artificial "bodies" -- thinking just a lipid bilayer sack with some ACE2 elements attached. Any virus that binds with that will "infect" the dummy cell but have no way of replica... (read more)

1leggi5y

This is very interesting information. I was wondering (but not enough to actually research it) why diabetes mellitus (DM) was a bigger risk factor of severe disease than I would have associated with the "normal" increased risk with infections in patients with DM. A quick search led me to this article in the Lancet.

1jmh5y

I believe there was also an issue related to glucose levels as well, which then results in worse infection outcomes with this virus. I just came across the following that might be of interest as well: https://www.eurekalert.org/pub_releases/2020-02/msa-arc022620.php That was from late February and I've not seen anything providing any update on the trials they were starting. Not sure if that is working as I was thinking, a decoy to get the virus to bind with something other then the cell and so neutralizing it.

[-]streawkceur5y30

Are there statistics/tables listing not only infections, but also not-infections with circumstances (X was quarantined because of contact with Y, but turned out to be negative)? This might help to assess the risk associated with certain situations (quickly buying something in a store, conversation in open air with distance, in a closed room etc.)

[-]AlexSchell5y30

This looks sketchy to say the least (e.g all citations are self citations), but seems worth doing a very shallow dive into or pointing out if clearly flawed: claim that yogurt can prevent secondary bacterial pneumonia in COVID-19 patients. The argument seems to at least imply that secondary bacterial pneumonia leading to cytokine storm is a common pathway to fatal cases.

(H/t Rob Wiblin on Twitter)

1leggi5y

Some quick thoughts if anyone wants to do a dive: The article is talking about "live" yoghurt i.e. cultured milk with no other additives. The main bacteria to culture milk into yogurt are: Lactobacillus bulgaricus (Lactobacillus delbrueckii subsp. bulgaricus) and Streptococcus thermophilus. In what countries do people eat a lot of natural live yoghurt? (per capita not overall amounts). Bulgaria (a clue in the name of the first bacterium) Russia? Greece? Spring to mind. Local knowledge would help here. What are the demographics of those populations? (total population, % of old folks most likely to suffer severe disease) What's the COVID19 situation in these places? The link says: I would want to see some evidence for this statement for instance levels of secondary infections being tested/confirmed/reported. (and the use of antibiotics as prophylactic or therapeutic agents - could antibiotics making things worse in some cases by killing of the good bacteria too????

[-]Iwein5y30

Is there any information on how exactly the testing process works? I'm trying to determine whether pool testing could be worthwhile. Test 10 samples at the same time to confirm if they're all negative. If not, test them all separately. At worst that's 11 tests to confirm postivie cases for 10 people, yet only one to clear 10. There's a million variables like expected infection saturation, grouping by symptoms/likelihood of infection, cost of the tests, duration of testing, number of test stations(is this even a bottle neck that needs a solution?) and of co

... (read more)

[-]micpie5y30

Interesting comment on a (maybe) new symptom, i.e., loss of smell and taste for several days, of a COVID-19 infection in an interview of a MD with focus on Virology in Germany:

Google translation of the interesting part:

"Almost all infected people we interviewed, and this applies to a good two thirds, described a loss of smell and taste lasting several days. It goes so far that a mother could not smell the full diaper of her child. Others could no longer smell their shampoo, and food began to taste bland. We cannot yet tell exactly when these symptoms ... (read more)

[-]Richard Meadows5y30

I am suspicious of the general advice against non-frontline health workers using masks (i.e. that anything short of a properly-fitted N95 mask is not only useless, but possibly does more harm than good). This air filter company claims that not only are masks a lot better than nothing; even home-made masks bodged out of cotton t-shirts or pillowcases catch 50-60% of virus-sized particles. Or as Naval suggested on Twitter, "billions of Asians aren't wrong."

I don't know whether this is correct, but am leaning towards wearing a mask in publ... (read more)

2Raemon5y

See previous discussion here: https://www.lesswrong.com/posts/7K8fSFTnpfN4EBuZ8/how-useful-are-masks-during-an-epidemic

1Richard Meadows5y

Cool, thanks. Still seems v. inconclusive... if anyone has more info, please chime in on that thread!

[-]streawkceur5y30

Are there attempts to build an app that tracks everyone by GPS, and notifies all possible contacts (and people having been in the same supermarket etc.) when someone develops a cough?

It seems to me that, with a majority of people using such an app, the R0 could easily be pushed below 1 without too many restrictions. I think this could even work when using the app is on a voluntary basis - I guess that people making wrong statements in such an app and getting someone sick amounts to negligent assault in many countries.

I don't believe the claims that 60% of

... (read more)

2gwillen5y

There are at least two attempts I'm aware of to do almost exactly this, surely more that I'm not aware of, plus some attempts to do other modeling (like, using people's tracks from fitness apps, so they don't have to install a new app.) I think it's going to be really unlikely to get enough people to use something like this to be useful, but I'd love to be wrong. If you want to help I'm happy to direct you to them.

3streawkceur5y

I actually think it is plausible that governments and/or Facebook do this, and it becomes widely enough adopted. A community-level risk score would already be helpful ("based on estimates in your locality, the risk of contracting the virus when taking a bus is X now...) for individuals.

2gwillen5y

Yeah, I think something at the government (or google/facebook) level would be a lot more effective. (Of course, people might have some qualms. China already did it, of course, and it's mandatory -- but that's China.)

[-]jp5y30

Does anyone want to venture a guess for the true number of cases in the Bay Area right now?

I just some rough back-of-the-envelope calculations, following the method here. Currently there are 2 deaths in the Bay Area. I keep his time-till-death rate of 17.3 days, but substitute a doubling time of 3 days, based on Our World in Data's US number. I get 2*100*exp(17.3*.231) ≈ 11,000, or about 2/1000 bay area residents. Super non-robust number, take with several grains of salt.

(.231 is the rate I get when solving for r in the exponential growth funct... (read more)

8kdbscott5y

I've been a bit confused about doubling rate. First, I noticed that many numbers (e.g. Wikipedia) are calculating how long it took to double, instead of projecting forward using e.g. yesterday's increase. Early on this led to misleading numbers, but recently the US has been steady around 2-3 days using both methods. However, I'm guessing that raw doubling rates depend a lot on testing, and that the US should expect to have a faster-than-actual doubling rate until our testing catches up. So I lean towards Trevor's number of 5 days.

[-]mako yass5y*30

It had not occurred to me that there were any obvious companies a person could invest in to benefit from (and contribute to and accelerate) the response to the pandemic, but https://www.lesswrong.com/posts/yuyvosHTgjDR4giPZ/why-don-t-singularitarians-bet-on-the-creation-of-agi-by mentions the videoconferencing software Zoom. It does seem to be the best videoconferencing software, from what I've heard. It's rare that I've ever had an international internet call from new zealand as stable as the ones I had on Zoom.

Any other industries a perso... (read more)

[-]Alexander Mont5y30

Hi, I have another few questions I'm interested in to help understand my own risks from the virus:

What's a good estimate for the percentage of the US population infected, right now?
What is the likelihood of transmission inside the home (i.e. if one of my family members gets it, what's the chance that I will get it?) What things can we do in the household to reduce this probability?
I'm concerned about the possibility that if I get it, there won't be hospital beds available. Would it make sense to, at the first sign of symptoms, get

... (read more)

3ErickBall5y

Please do not get on a plane if you have symptoms. If you are in a high risk category and/or very scared, you could go to Singapore preemptively, since they've already shown they can control their outbreak.

2Ben Pace5y

My current working assumption is that if you share a living space and/or a bathroom with someone who gets it, you will get it within a few days. If you want to reduce the probability, make sure you don't use any common spaces or bathrooms.

[-]Original_Seeing5y30

A strong preventative measure I haven't been hearing people talk about in general is constant cleaning of commonly touched surfaces. In workplaces and homes, this may be more valuable than encouraging people to wash their hands very often.

The Coronavirus can persist on steel, metal, wood, and plastic for up to 4 days according to the link below. Cleaning surfaces several times per day with an appropriate cleaning agent would therefore be highly valuable to implement.

There's not much point in constantly washing your hands if your office/home&apos... (read more)

[-]Eli Tyre5y30

Can we estimate what level of the disease will overtax US hospitals?

This page says that three are 924,107 "Total Staffed Beds in All U.S. Hospitals." Is that a good estimate of overall hospital capacity?

Does that mean that if/when ~ 1,000,000 people in the US have symptomatic cases, the hospital system will be at capacity?

3Michael McLaren5y

Comments on hospital capacity models from other threads in this post: * https://www.lesswrong.com/posts/ACyGvQchWzGjGkKgS/coronavirus-open-thread#GXpQihDMgRA7EfgYS * https://www.lesswrong.com/posts/ACyGvQchWzGjGkKgS/coronavirus-open-thread#jC7CGd7KuuwLu5FT5 * https://www.lesswrong.com/posts/ACyGvQchWzGjGkKgS/coronavirus-open-thread#mYxKedFDALDS8v2S8 Other models / estimates: * http://www.centerforhealthsecurity.org/cbn/2020/cbnreport-03132020.html * https://medium.com/@trentmc0/when-does-hospital-capacity-get-overwhelmed-in-usa-germany-a06cf2835f89 * https://www.nytimes.com/interactive/2020/03/13/opinion/coronavirus-trump-response.html

3Michael McLaren5y

This preprint from Marc Lipsitch and colleagues is relevant, Li R, Rivers C, Tan Q, Murray MB, Toner E, Lipsitch M. 2020. The Demand for Inpatient and ICU Beds for COVID-19 in the US: Lessons From Chinese Cities. https://dash.harvard.edu/handle/1/42599304 See their Figure 1 where they plot the hospitalization rate during the Wuhan epidemic against US hospital bed capacity to give an idea of how quickly the US would be overloaded in a "Wuhan-like outbreak". They consider ICU beds (2.8 per 10000 adults), empty ICU beds (31.8% of all ICU beds), and what they call "US inpatient beds in community hospitals" (29.7 per 10000 adults). The sum of ICU and community beds comes out to ~850000 based on an adult US population of 240 million, which isn't too far off from your 924107 number. Two things to keep in mind for working through your question about the implications of 10^6 (concurrent) cases (I see these are reiterating points Mark already made): On the one hand, most symptomatic cases will not need hospitalization. On the other hand, most hospital beds are occupied (~70% of ICU beds, which roughly agrees with Mark's 66% estimate for overall beds), so the number of available beds is much less than the total number of staffed beds. I've heard it suggested that today's declared national state of emergency and associated funding may enable things like FEMA building field hospitals to extend hospital bed capacity. Edit: see also this blog post by author Eric Toner about the above preprint, http://www.centerforhealthsecurity.org/cbn/2020/cbnreport-03132020.html

2Mark Xu5y

Based on googling "hospital occupancy rates", about 66% of beds are already in use on any given day. Doctors I've talked to have said that extremely busy days result in near or over 100% capacity. I expect that there is going to be gradual overload as COVID spreads through various communities, e.g. we're starting to see Washington hospitals starting to be overloaded A rough estimate: there are ~333k empty hospital beds, a doubling time of 4 days, 300 new cases today, 0.2 percent of patients hospitalized and 14 days per hospitalization. Thus we want to solve for k such that ∑k+14n=k0.2∗300∗2(k/4)>333,000, giving k > 34, so hospitals will be overloaded in 34 days. This estimate assumes that patients are distributed uniformly throughout all hospitals, so it's more of an upper bound given unchecked exponential growth. Edit: Rob Wiblin provides an estimate (on FB) of 15k new cases in the US every day, giving k > 11.5. I haven't thought much about 15k new cases, but it seems far more correct than 300.

[-]Josh Jacobson5y30

It seems plausible to me that the copper tape approach many LWers have adopted is counter-productive in at least some cases. The logic for this is:

1. In the pictures I've seen, and with my own applications of copper tape, to the surfaces we seem to touch most often (e.g. doorknobs, light switches) applications of it have created a number of small creases, bumps, ridges, and/or folds.

2. Copper does not seem to have nearly as strong an effect on surfaces as does wiping them with disinfectant.

3. Wiping them with disinfectant seems likely to be a lot less effective on surfaces that aren't smooth (bumps, ridges, etc.) due to the difficulty in wiping all parts of the surface.

Thoughts?

[-]gwillen5y110

I think the problem with this is the burden of wiping down surfaces often enough to be effective. Copper appears to take a few hours to effectively render the virus undetectable (according to https://www.statnews.com/2020/03/09/people-shed-high-levels-of-coronavirus-study-finds-but-most-are-likely-not-infectious-after-recovery-begins/, just out today.) So to get the same effect from wipes, I would presumably need to fully wipe down all those surfaces every few hours at least, and I would need to not run out of wipes.

I think for high-touch surfaces in widely-shared environments (e.g. offices), probably disinfecting every few hours or more often is a good idea, and better than the passive benefits of copper. At home I think copper is likely to win out, unless your house is really on the ball about disinfecting things.

2habryka5y

I've also considered this. I think there is some chance of this being the case, and I think we should take it seriously. I've been considering sanding down all of the surfaces we covered with copper tape with sandpaper, to make sure they are actually smooth. I do disagree with this though: My current sense is that wiping them down with disinfectant works totally fine, since at least the disinfectant we use is pretty wet and seems to get into creases and bumps just fine.

1Original_Seeing5y

A downside of using copper may be that exposing it to disinfectants could lead to a decrease in its efficacy. Ethanol is listed specifically. Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067274/#r1 The claimed exception to this is "a 1% nonionic detergent solution".

[-]Sherrinford5y30

My impression is that some Fermi estimate approaches assume that exponential growth indeed goes on until it hits the wall of 100%. Exponential growth is represented by ds/s = x, where s is the stock (here of infected people) and x is a constant. To my intuition, logistic growth ds/s = y (1-s) is almost as simple and it has the feature of a built-in limit. Of course both models imply 100% infection rates, but the second one asymptotically. The logistic model in this specification has highest absolute growth when 50% are infected, then lower (but still positive) growth because, e.g., infected people meet more who already infected.

Sorry if this is already common knowledge.

[-]Gurkenglas5y30

Should we be buying something like oxygen concentrator/medical ventilator futures? This might make money and increase production. I'm not sure how to go about it, though.

[-]Ivan Denker5y30

Assuming kids catch and spread the virus without sickening much, and that immunity among previously ill adults is robust, I would send my kids to a summer camp with immune counselors and lots of spit swapping (bobbing for apples, spin the bottle, being kids).

Any plausible way to use the mildness of illness in kids to develop herd immunity more quickly, rather than having them return home to parents and grandparents every day with deadly sniffles from the viral reservoir that is school?

2TobyBartels5y

Everybody says that immunity to coronaviruses is not robust (although we don't know yet about this specific one).

[-]Adam Zerner5y20

Is it possible that there are different viruses we're dealing with here? It just doesn't make sense to me that we're seeing such varying death rates, eg. Italy vs South Korea. The difference in medical quality doesn't seem like it can explain it.

2Elizabeth5y

There are already different strains identified, seems plausible some are worse than others.

1leggi5y

The current tests are looking for the presence of a specific virus - looking at the genome using RT-PCR technology so the answer is no. (eek at being so definite) PCR (polymerase chain reaction) is a DNA amplification technique but Coronavirus is RNA so reverse-transcriptase (RT) is used to make a DNA 'template' from the RNA. Some info. from Cambridge and Glasgow Universities regarding Covid-19 Genomics UK Consortium - A project to map how COVID-19 spreads and behaves by using whole genome sequencing will show if the virus is mutating. Consider the demographics of the populations. Age, concurrent disease, levels of smoking, air pollution etc... Levels of testing/recording/reporting.... (hope this makes some sense - written in a rush)

[-]Alexei5y20

A random thought: If the virus doesn't survive well in high temperatures would going to a sauna help treat it?

4Vaniver5y

This abstract says "Sauna takers should avoid bathing during acute respiratory infections." I haven't read the paper to figure out why they think that.

3Alexei5y

The whole abstract: So I think they're specifically talking about bathing; while the sauna (dry air) is actually good. I can't find the entire paper but if someone send me a link, I'll look more into it.

[-]willbradshaw5y20

Last month, NIAID RML released an album of SEM and TEM images of SARS-CoV-2. This includes the multi-coloured image everybody is using but also a lot of other very striking images. Check it out!

[-]James_Miller5y20

Consider getting a humidifier in case someone in your household gets COVID-19, because high humidity might reduce the transmission of the virus.

[-]Vanessa Kosoy5y20

I remember reading some speculation that Zinc supplements and (separate speculation) garlic supplements might have some beneficial effect against COVID19, but can't find the source. Anyone knows what's the status on that?

[-]Gunnar_Zarncke5y20

I have seen quite a bit of advice here or elsewhere but not so much what people actually do. I'd like to post a poll but unfortunately that is no longer possible. But maybe you can comment here what you do.

In the spirit of this question I have written this on my FB page:

https://www.facebook.com/gunnar.zarncke/posts/1142992466050982

[-]Leon Lang5y20

Is there anything precise known about the distribution over the severity of symptoms I should expect as a 20-30 year old? I'm in that age-group, that's why I'm interested.

So, what I'd like to know specifically, conditional on being infected, is:

How likely would I be asymptomatic?
How likely would I have symptoms not more severe than the common cold?
How likely would symptoms comparable in severity to the flu (being mostly in the bed for maybe 2 weeks but nothing more)?
How likely would I have mild to moderate pneumonia with which I could s

... (read more)

[-]TurnTrout5y20

My roommate tested positive for type A flu. Does this mean he is unlikely to have COVID?

4habryka5y

Comorbidity is low, from what I remember, so I do think a positive non-COVID case is pretty indicative and should revert your risk-estimate relatively close to population level (I think, probably a factor of two higher or so, would be my random guess). Though I would strongly recommend continuing to measure fever and ideally use one of those oxygen-level measurement thingies that would allow you to notice if things get really bad and you should definitely go to a hospital.

2James_Miller5y

Greg Cochran told me in one of our podcasts that having the flu probably provides protection against getting COVID19 because having the flu activates your immune system.

[-]ChristianKl5y20

It's a mystery for me why https://www.lesswrong.com/posts/aqTwwvBv84rjqKvnk/why-isn-t-increasing-ventilation-of-public-spaces-part-of hasn't received any votes. It seems to me a very crucial question which a lot of possible upside if we get it right and get the information out about a easy to implement beneficial intervention.

4Raemon5y

I think the answer is most likely "there's just tons of coronavirus content right now and it's hard for people to keep track of it all." I'm hoping in the nearish future we can do some retrospective organizing of the existing questions and try to prioritize them.

[-]Liron5y20

This seems like a good time to sign up you and your loved ones for cryonics

4DanielFilan5y

FWIW I suspect cryonics orgs may not have capacity to handle the increased case load over the next few months.

2TurnTrout5y

Doesn't directly answer this concern, but: I just called the Cryonics Institute, and they said that CI and Suspended Animation both plan to continue offering services during the pandemic.

2DanielFilan5y

Although I'd love to be proven wrong about this.

[-]cata5y20

Here's a preprint published on March 10th testing how long coronavirus can last on a variety of surfaces.

[-]Gunnar_Zarncke5y20

This is an interesting timeline of people in different countries (or speaking different languages) looking for information on the corona virus - based on Wikipedia view stats:

https://towardsdatascience.com/coronavirus-interest-inwikipedia-by-language-1b3e6562040d

[-]streawkceur5y10

EDIT: The South Korean press releases contain a chart somewhat like the one I wanted, see e.g. https://www.cdc.go.kr/board/board.es?mid=a30402000000&bid=0030

I am looking for a better overview of imported cases by country of origin in East Asian countries.

EDIT: I remembered incorrectly, the following is wrong. In particular, I recall a statistic according to which a significant number of imported cases in South Korea in one day ~1-2 weeks ago came from China (~12, vs ~40 Europeans).

If this is true, this would seem to me like strong evidence that China i

... (read more)

[-]syllogism5y10

Does COVID-19 have a long "incubation period" because we don't have any immunity to it?

This is a "makes sense to me" idea I merely thought of, and I have 0 medical expertise. So this is probably dumb, but now that I've thought of it I keep wondering whether it's true.

My thinking is that the early symptom onset we feel when we get a cold or flu is partly down to our immune system responding, which causes inflammation etc. With the novel coronavirus, the immune system isn't responding early on, and the infection itself will be in the slow ramp stage of its exponential growth, so the infection is already well established by the time you start to feel it.

[-]ignoranceprior5y10

Does anyone have thoughts on the recent Oxford study that claims that only a very small minority of infections lead to hospitalization or death, and that >50% of the UK population is already infected?

https://www.dropbox.com/s/oxmu2rwsnhi9j9c/Draft-COVID-19-Model%20%2813%29.pdf

[-]Wei Dai5y120

Does anyone have thoughts on the recent Oxford study that claims that only a very small minority of infections lead to hospitalization or death, and that >50% of the UK population is already infected?

https://twitter.com/CT_Bergstrom/status/1242611599405277184

6[anonymous]5y

' Imagine if I were to write a paper about a thought experiment: "Could evolution work if animals didn't die?" Well, the equivalent @FT headline would read "We may be immortal—UW study." It's that bad. '

5[anonymous]5y

My thought can be summed up with the word "bullshit". The numbers required for that high an infection rate are orders of magnitude off what we know from the Diamond Princess data alone.

[-]leggi5y10

Covid-19 Genomics UK Consortium - A project to map how COVID-19 spreads and behaves by using whole genome sequencing.

Some info. from Cambridge and Glasgow Universities (UK government/NHS many other UK universities involved too).

[-]leggi5y*10

I've just stumbled across this press report:

A man has died and his wife is under critical care after the couple, both in their 60s, ingested chloroquine phosphate, an additive commonly used at aquariums to clean fish tanks. Within thirty minutes of ingestion, the couple experienced immediate effects requiring admittance to a nearby Banner Health hospital.

No mention of how much they ingested.

Chloroquine phosphate for fish-tanks, not human grade.

But a little knowledge without understanding can be a dangerous thing ...

[-]zby5y10

A meta question - can we find areas with mismatched incentives (à la https://equilibriabook.com/ ), and biases, where the applying the rational thinking methodology would have high leverage? What can LessWrong do better than official science?

3ChristianKl5y

I don't think that there's a single "rational thinking methodology". We have a bunch of different tools. While the current FDA works at allow Moderna to do their human trials very early, it seems the same isn't true for the EMA and CureVac who advises CureVac to do their first human trial only in early summer. Getting the public to be angry at the EMA for giving advice that delays a potential vaccine might be a point of high leverage. There seems to be a strong need to get the educated public informed about the vaccine development business, so that we can exert public pressure on making it faster at the right points. https://www.lesswrong.com/posts/SQDKMFmJToYqhZT5d/mrna-vaccine-development-for-covid-19 https://www.covid-watch.org/ for not privacy violating smart phone contact tracing is high leverage that might not get enough support from existing institutions. Quantified Self has many points where the existing institutions aren't yet focused enough. https://www.lesswrong.com/posts/6kj6cbcsMQFt4ntd9/using-the-quantified-self-paradigma-for-covid-19

[-]zby5y10

Favipiravir - I have not seen this yet here, but it looks actually even more promising than chloroquine: https://en.wikipedia.org/wiki/Favipiravir

Reduction from 11 to 4 median days of treatment.

[-]jmh5y10

Looks like the OurWorldinData has a graph showing a decrease in the total number of reported new cases for the world. Obviously, one observations is nearly meaningless but might be a sign that the curve is starting to flatten.

[-]Lucent5y10

As a child who repeatedly got tonsillitis several times a year, sometimes when totally isolated and sometimes later hearing everyone else around me also got a sore throat, I grew up confused as to why contagious disease tracking was a problem we'd given up on and accepted. No doctor was ever curious of the specific virus or bacteria which caused it. While no one case greatly affected my life, as a whole they very much did. Then again, I was also struck by the possibly false realization that many STDs which have followed us for thousands of years could be p

... (read more)

[-]DirectedEvolution5y10

I'm gathering info on anti-COVID-19 drug efforts. Here is what I've compiled so far. I've combined the number of trials in various phases with big data on expected success rates for drugs in those phases to forecast an 80% probability that at least one drug currently in phase 1-3 testing will be approved. Because trial efforts are unusual, I've used the following categories in my model:

0: pre-trial (not factored into probability of success)

1: new drug in early testing

2: approved drug being tested against COVID-19

3: official phase 3 tria... (read more)

[This comment is no longer endorsed by its author]Reply

[-]Liam Donovan5y10

Is this the right kind of copper tape for keeping surfaces virus-free? I'm concerned because it doesn't seem to have sharp edges, which I've heard is a big issue with the right kind of tape

https://smile.amazon.co.uk/Selected-Repellent-Copper-Conductive-Adhesive/dp/B07TV26465/

2jimmy5y

Yes, that looks right. The edges of any thin tape are going to be sharp, it's just that copper is strong enough to hold that geometry instead of folding easily before it cuts you.

1Liam Donovan5y

Well that's why I was concerned that this tape doesn't have sharp edges!

2jimmy5y

I'm not sure what makes you think it doesn't have sharp edges. In order to not have sharp edges it would need to be a bar, not flexible tape.

[-]willbradshaw5y*10

I'm working on a document / series of posts about coronavirus biology – viral structure, replication cycle, that sort of thing. This is mostly for my own education but I figure it's also a useful exercise to make the result public in a presentable form. I'm posting this here (a) as a commitment device to get something out in the next week or so, and (b) to see if anyone has any questions they'd like answered in this area that I could look into.

Currently I'm mainly learning about coronavirus biology in general, expect to switch to COVID19 specifically in a couple of days.

1sprague5y

check out: http://virological.org/uploads/short-url/z0cOhZzme3C6HtlcOcE61uMwJmU.pdf

3willbradshaw5y

Thanks but I'm not asking for sources. I have lots of sources already.

1zby5y

The best article for an interested lay person I have seen is this The Economist article: https://www.economist.com/briefing/2020/03/12/understanding-sars-cov-2-and-the-drugs-that-might-lessen-its-power Here is an outline: https://outline.com/Ma9nV7

1willbradshaw5y

Thanks, this is a nice layman's overview. I'm not a layman, though, and I'm planning on going much deeper than this (I've spent a lot of my weekend buried in virology textbooks). From the article: "HIV and SARS-CoV-2 have about as much in common as a human and a satsuma" I wonder whether this is just journalistic flair or actually grounded in something. They don't cite their sources very well, unfortunately.

[-]benyeoh5y10

Is COVID really helping the environment? Some articles suggest there's a postive short term impact from lower air pollution, but when I looked at long term CO2 in the atmosphere there's been no impact. Would be interested in thoughts? Blog here: https://www.thendobetter.com/investing/2020/3/12/no-impact-seen-on-atmospheric-co2-in-q1-2020

[-]KevinO5y*10

Edit: apparently the cited study does say that no viable SARS-COV-2 virus was found on the copper after 4 hours.

Original comment:

Dr. Peter Hotez said on the podcast The Drive (https://peterattiamd.com/peterhotez/) that a new (March 13) paper (https://www.medrxiv.org/content/10.1101/2020.03.09.20033217v2) found that SARS-COV-2 could last for 8-24 hours on copper. If you search for "copper" in the show notes you'll find the 8-24 hour figure.

[-]qirlib5y10

Is it possible to quickly develop (within 24h) respiratory failure or breathing difficulties without having severe onset symptoms (i. e. fever, perhaps chest pain (chest congestion) or unstoppable cough)? Which symptoms exactly should be looked out for? If the possibility of suddenly going straight to blue is unavoidable, what is the distribution of how exactly physically able and mentally coherent you are likely to become when that happens?

(personalized: There's a considerable probability I'm already infected and my isolated space is located in ... (read more)

2Elizabeth5y

According to https://www.facebook.com/jeanqasaur/posts/10111638281986401 , symptoms are often not sudden onset, but my impression is it can get worse quite suddenly, as the virus moves from upper to lower respiratory system. The primary way to know if things are getting serious is shortness of breath, but, uh, that seems really bad to wait for if you need to walk a mile to get help. This is really speculative on my part, but: this might be a good candidate for a pulse/ox meter. Normally I think they aren't very useful because you can go by symptoms, but it might (might) be useful in your case, if you can monitor frequently enough to catch a dropping oxygen concentration before it interferes with your breathing (I do not know if the meters are accurate enough to do this).

3ErickBall5y

Hopefully someone more knowledgeable can weigh in, but in the meantime I want to sound a note of caution on this: my experience with pulse oximeters is that by the time it drops noticeably below normal, you are already quite sick and walking a mile may not be practical. The point of the pulse ox is more to be able to quantify your symptoms so that you can have a specific threshold for when you should seek emergency treatment. I don't believe it's a leading indicator and so it may not be helpful for this situation.

[-]jmh5y10

Drive through screening test? Would they be good for the USA and EU?

[-]jmh5y10

Just looked at a link for a Vox article that popped up when I launched my browser. Nice chart but would be interesting to know some thing about the model parameters (and I think the graph is illustrative not anything factual or based on some model CDC has) that would be required to achieve the image, and some sense about how close both USA and EU are to achieving the parameter values.

I thought the interesting thing about is was that the goal is not really about reducing the number of infections. That is not really a narrative that is in the public media at this time -- or I'm missing it.

2AlexSchell5y

I made a model that tries to replicate the chart, see here.

1jmh5y

Thanks. BTW, have you thought about putting an average recovery/dies period in, perhaps differing based on hospital bed or ICU and look at how those parameters might shift things a bit? Might even be good to model the time between infection and need for medical care (be that bed or ICU). Or are those implicit in your beta and gamma values?

[-]Josh Jacobson5y10

Take someone in the U.S. who is heavily immunocompromised, such that their risk of death from any infection beyond a mild cold averages to 15%, and assume that their risk of death from coronavirus is 100%. Assume they've been employing social distancing tactics as a result for some time.

Is there available information or projections on whether the total risk for this person has increased or decreased as a result of coronavirus?

A key assumption/the reason it may have decreased is that we could expect that the prevalence of all other diseases is falling due to the social distancing tactics being employed for coronavirus.

[-]vidro35y10

1) are we going to create some super-bacteria by using a ton of hand sanitizer and wipes?

2) Is this report of 40-70% infection rate world-wide reputable, realistic, useful?

https://thehill.com/changing-america/well-being/prevention-cures/482794-officials-say-the-cdc-is-preparing-for

In my view we don't know what percentage of infections result in a) symptoms, b) serious symptoms. It's pretty easy to take those estimates coupled with current death rates and get a result of 100million deaths due to COVID-19. That seems super extreme and unlikely to m... (read more)

5TobyBartels5y

1. Alcohol and bleach are both extremely common in our current environment, so if it's possible to create these superbugs, then we should already be doing it, although this could speed up the process. And quick Google searches tell me that nothing is evolving resistance to bleach; but we are indeed creating alcohol-resistant superbugs that are starting to infest hospitals. So those may get worse.

[-]Thomas5y-10

CROSSPOST from my blog:

https://protokol2020.wordpress.com/2020/03/27/covid-19-a-view-to-a-kill

The R0 factor for this illness, which denotes the average number of people infected by a carrier, isn't a constant, it's a function of time. R0 = R0 (time). In fact, it's a function of more parameters and not just time. For example, if quarantined, R0 should be close to 0. There are many unknown factors here, of course, some even known. Some push this now well known R0 term bellow 1, others above 1. It's all about reducing R0 below 1, and the ... (read more)

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