So there's this blog called Bad Science, consisting mostly of the articles that medical doctor Ben Goldacre writes for the Guardian. It's about pseudoscience, medicine and medical research. And also awesome.
The recent article was a wonderful bit of emotional whiplash, and is about as subject I think is useful to keep in mind when contemplating research. But really, I recommend reading everything.
http://www.badscience.net/2011/05/existential-angst-about-the-bigger-picture/
Also, the second-most-recent article, which should appeal to LW-types:
http://www.badscience.net/2011/05/we-should-so-blatantly-do-more-randomised-trials-on-policy/
Ben Goldacre in general is a really good writer. I remember in his most recent book when he talks about publication bias he included a study suggesting that there was a publication bias in studies about publication bias.