So I would've agreed with you even a month ago, but then I was informed of the Rootclaim debate over the origins of Covid19 with $100,000 at stake. And oh boy, did that debate (and Daniel Filan's helpful coverage!) change my mind on the likelihood of the lab-leak hypothesis. Franky, this is the minimum standard we should've held as to the inquiry of such an important topic as a society. Regardless, it change my mind from about 70% likelihood of a lab-leak to about 1-5%. Manifold seems to agree, given the change from ~50% probability of lab-leak winning to 6%.
EDIT: To clarify, this comment was a recommendation, not an argument. Second, I didn't watch the whole debate. Instead, I watched the opening arguements, snippets of later parts of the debate, and read through Daniel's thread which made sense given the content I had watched. I apologize for not making that clear. Mea culpa. Third, the debate covers the Defuse proposal. [1]
I still recommend looking at parts of the debate (they're handily timestamped!) which consists of written, and verbal segments. Or you can wait until the condensed 2-hour version is released. Either way, the breadth of evidence considered, and the a...
Regardless, it change my mind from about 70% likelihood of a lab-leak to about 1-5%. Manifold seems to agree, given the change from ~50% probability of lab-leak winning to 6%.
Manifold updating on who will win the debate to that extent is not the same as manifold updating to that extent on the probabilty of lab-leak (which various other markets seem to roughly imply is about 50/50, though the operationalization is usually a bit rough because we may not get further evidence).
Could you please list your relevant object-level arguments for the lab-leak being unlikely?
(Posting a link to an extremely long, almost 17 hours, YouTube debate, and to bets on it based on a judgement of unknown judges, is not very helpful and doesn't itself constitute a strong counterargument to the lab-leak arguments in this post. This is similar to how pointing to the supposed "winner" of a recent AI risk debate isn't a strong argument against AI risk.)
I have only skimmed the early parts of the Rootclaim videos, and the first ~half of Daniel Filan's tweet thread about it. So it's possible this was discussed somewhere in there, but there's something major that doesn't sit right with me:
In the first month of the pandemic, I was watching the news about it. I remember that the city government of Wuhan attempted to conceal the fact that there was a pandemic. I remember Li Wenliang being punished for speaking about it. I remember that reliable tests to determine whether someone had COVID were extremely scarce. I remember the US CDC publishing a paper absurdly claiming that the attack rate was near zero, because they wouldn't count infections unless they had a positive test, and then refused to test people who hadn't travelled to Wuhan. I remember Chinese whistleblowers visiting hospitals and filming the influx of patients.
It appears to me that all evidence for the claim that the virus originated in the wet market pass through Chinese government sources. And it appears to me that those same sources were unequipped to do effective contact tracing, and executing a coverup. When a coverup was no longer possible, the incentive would have been to confidently identify an origin, even if they had no idea what the true origin was; and they could easily create the impression that it started in any place they chose, simply by focusing their attention there, since cases would be found no matter where they focused.
My impression from that is that Peter Miller is engaging in sophistry and is very good at it, and Rootclaim is very bad at debating. But I don't have 17 hours to get into the weeds of that exercise.
Edited: having skimmed the comments section on Manifold which is a lot faster than watching 17 hours of debates, it seems that Miller is just better at rationality than the Rootclaim guy. I don't see anything there to lead me to believe that WIV is unconnected to covid-19, but it looks like Miller has the better arguments and considers things from many angles.
I think this kind of gladiatorial format is bad for getting at the truth; Miller and Rootclaim should just lay out their arguments in a hierarchical form so it's easy for many eyes to spot the weak points.
I think it's less your obligation to weed through a 17 hour debate than it is Algon's obligation, who implies he watched the debate, to list here the arguments that convinced him that the lab-leak hypothesis is false.
I think it is Roko's obligation to do a better job of researching and addressing counter-arguments before making a post like this one. It contains absolutely nowhere near sufficient justification for the accusations it is leveling.
So, from my perspective there are two different issues, one epistemic, and the one game-theoretic.
From the epistemic perspective, I would like to know (as part of a general interest in truth) what the true source of the pandemic was.
From the game-theoretic perspective, I think we have sufficiently convincing evidence that someone attempted to cover up the possibility that they were the source of the pandemic. (I think Roko's post doesn't include as much evidence as it could: he points to the Lancet article but not the part of it that's calling lab leak a conspiracy theory, he doesn't point to the released email discussions, etc.) I think the right strategy is to assume guilt in the presence of a coverup, because then someone who is genuinely uncertain as to whether or not they caused the issue is incentivized to cooperate with investigations instead of obstruct them.
That is, even if further investigation shows that COVID did not originate from WIV, I still think it's a colossal crime to have dismissed the possibility of a lab leak and have fudged the evidence (or, at the very least, conflicted the investigations).
I think it's also pretty obvious that the social consensus is against lab leak not because all the experts have watched the 17 hour rootclaim debate, but because it was manufactured, which makes me pretty unsympathetic to the "researching and addressing counter-arguments" claim; it reminds me of the courtier's reply.
I honestly think most people who hear about this debate are underestimating how much they'd enjoy watching it.
I often listen to podcasts and audiobooks while working on intellectually non-demanding tasks and playing games. Putting this debate on a second monitor instead felt like a significant step up from that. Books are too often bloated with filler as authors struggle to stretch a simple idea into 8-20 hours, and even the best podcast hosts aren't usually willing or able to challenge their guests' ideas with any kind of rigor. By contrast, everything in this debate felt vital and interesting, and no ideas were left unchallenged. The tactic you'll often see in normal-length debates where one side makes too many claims for the other side to address doesn't work in a debate this long, and the length also gives a serious advantage to rigor over dull rhetorical grandstanding- compared to something like the Intelligence Squared debates, it's night and day.
When it was over, I badly wanted more, and spent some time looking for other recordings of extremely long debates on interesting topics- unsuccessfully, as it turned out.
So, while I wouldn't be willing to pay anyone to watch this debate, I certainly would be willing to contribute a small amount to a fund sponsoring other debates of this type.
This is written in a sensationalist style that I find frustrating - especially because in the intro I was beginning to get interested in how you were going to dive into the mechanics of manufactured consensus. I agree that it seems plausible it's a lab leak. However, I would have expected you, of all people, to want to reserve "crime of the century" for a different group of scientists. Small downvote for unnecessarily political-emotionally charged writing, especially when trying to counter existing political-emotionally charged writing. I agree that the intro describes accurately a large part of why I am having this reaction in the way I am, and that ducking under manufactured consensus to discuss this is useful - but I actually think that if we're going to be trying to discuss under manufactured consensus, that it's more and not less important to avoid sensationalism, in order to honor the emotions of people who will feel threatened by thinking they're going to be the odd one out. I mean, like, the ratio of that problem on lesswrong is somewhat reduced, but it's not zero. In any case, I agree that if gain of function research was the cause, it's one of the worst crimes of the past century so far, and that it is plausible. After all, manufactured consensus occurs even when something is true, because outside of certain kinds of scientific communities people have a significant amount of trouble being predictively calibrated at all. Even when they are observing things directly, their views about them tend to be an oversimplified over-weighted consensus.
I am quite aware of the severity of the harm done by the virus, and if that was caused by gain of function research, that's obviously terrible and an atrocity on the scale of the worst ones of the past century, compare eg colonial starvation of india, holocaust, holodomor, etc. However, I think discussing it in a way that explicitly invites the readers to give themselves time to evaluate the evidence piece by piece will produce better reactions in people who subscribe to consensus. If you simply want to push false consensus in the other direction, sensationalism is appropriate; otherwise, it is not effective.
edit: Roko's reply seems to me to have missed the point, but he's absolutely correct, it's just not related to my point; so, strong agree vote, no karma vote.
I heard about a practice that people perform the work for which they ask the grant - before the application.
First, because why not to cover my expenditures?
The second reason is that if the biggest part of the work for the grant is already performed, it is much easy to be sure that the idea will work and much clear what actually write in the grant. Your grant application will look great if it will based on already performed work.
Thus the grant may describe the work they already performed.
How do we know that this DEFUSE proposal really exists? I've seen some pay-walled articles from (to me) reputable news sources, but they are pay-walled so I couldn't read them fully. The beginning of one says they were released by some DRASTIC group I've never heard of. I would appreciate if you could provide some more direct evidence.
Thank you for answering, I'm sure this will convince a big fraction of the audience!
Maybe, as an European I'm missing some crucial context, but I'm most interested in the pieces of metadata proving the authenticity of the document. I can also make various official-seeming pdfs. (Also, I'm kinda leery of opening pdfs) Do you have, for example, some tweet by Daszak trying to explain the proposal (which would imply that even he accepts its existence) ? (or a conspicuous refusal to answer questions about it or at least a Sharon Lerner tweet confirming that she did upload this pdf)
https://twitter.com/PeterDaszak/status/1636155765185564680
"Peter Daszak @PeterDaszak Exactly. In fact the DEFUSE grant proposal was based on 10+ yrs of research on CoVs in the lab & in nature, which is why it accurately targeted the viral groups most likely to emerge. But conspiracists should also remember that this was a 'proposal', not a 'grant'."
A historical analogy might be the assassination of Bardiya, who was the king of Persia and the son of Cyrus the Great. Darius, who led the assassination, claimed that the man he killed was an impostor who used magic powers to resemble the son of Cyrus. As Darius became the next king of Persia, everyone was brute forced into accepting his narrative of the assassination.
Zhao Gao was contemplating treason but was afraid the other officials would not heed his commands, so he decided to test them first. He brought a deer and presented it to the Second Emperor but called it a horse. The Second Emperor laughed and said, "Is the chancellor perhaps mistaken, calling a deer a horse?" Then the emperor questioned those around him. Some remained silent, while some, hoping to ingratiate themselves with Zhao Gao, said it was a horse, and others said it was a deer. Zhao Gao secretly arranged for all those who said it was a deer to be brought before the law and had them executed instantly. Thereafter the officials were all terrified of Zhao Gao. Zhao Gao gained military power as a result of that. (tr. Watson 1993:70)
From Wikipedia.
Small nitpick:
Then in late 2019, a novel coronavirus that spreads rapidly through humans, that has a Furin Cleavage Site, appears in... Wuhan... thousands of miles away from the bat caves in Southern China where the closest natural variants live, and only a few miles from Wuhan Institute of Virology
I don't think it's thousands of miles away. The caves where RaTG13 (one of Covids closest relatives and the same virus that was sampled by the Wuhan institute of virology) was first discovered are in Mojiang Hani Autonomous County, Yunnan, about 930 miles away (you can check on Google maps).
Separately, the bat populations being far away makes sense in the context of "natural origin" theory, which purports that the virus didn't jump straight from bats but passed first through an intermediate (pangolin or what have you) before jumping to humans. That the bat population isn't in Wuhan doesn't necessarily make it less likely to be natural origin. This might not have been what you implied (though it's how I read it).
In the case of SARS CoV-1, the first case we know of appeared in Foshan. However, the most likely originating bat population reside in a cave 1,000km away (621 miles)
A...
Isn't the fact that it's the largest wet market in central China relevant here? Surely that greatly increases the chance of it travelling to Wuhan specifically in a zoonotic origin scenario, because animals are brought there from all around.
It doesn't directly strengthen the lab leak theory: P(emergence at Wuhan & caves distant | leak) is pretty similar to P(emergence at Wuhan & caves nearby | leak).
It does greatly weaken the natural origin theory: P(emergence at Wuhan & caves distant | natural) << P(emergence at Wuhan & caves nearby | natural).
If those are the only credible alternatives, then it greatly increases the posterior odds of the lab leak hypothesis.
If you're interested in the first principles/psychological dynamics that this phenomenon is downstream of is Social Status, well described in Simler's Social Status: Down the Rabbit Hole, and tendency towards excessive self-importance (and the equilibria where we excessively anticipate that excessive tendency in others), described in Carnegie and Gull's post Win friends and influence people: the bombshell.
My model of the US Natsec community's secret activities indicates that they would engage in ambitious suppression of information about lab leak hypothesis, regardless of whether it was true, or their imagining of the odds that it was true or false. This is because:
1) such information, if public, would damage US-China relations, regardless of whether or not it was true. Failing to suppress this information incentivises information operations by third parties who benefit from destabilizing US-China diplomacy, potentially including Russians, North Koreans, or war hawks within the Natsec comminity itself who profit off of worsening US-China relations.
2) Compartmentalization and funding turf wars within the Natsec community can cause information asymmetry and lack of trust between agen...
Since a few people have mentioned the Miller/Rootclaim debate:
My hourly rate is $200. I will accept a donation of $5000 to sit down and watch the entire Miller/Rootclaim debate (17 hours of video content plus various supporting materials) and write a 2000 word piece describing how I updated on it and why.
Anyone can feel free to message me if they want to go ahead and fund this.
I would be very interested to see a broader version of this post that incorporates what I think to be the solution to this sort of hivemind thinking (Modern Heresies by @rogersbacon) and the way in which this is engineered generally (covered by AI Safety is dropping the ball on clown attacks by @trevor). Let me know if that's not your interest; I'd be happy to write it.
The post titled "Most experts believe COVID-19 was probably not a lab leak" is on the frontpage yet this post while being newer and having more karma is not. Looking into it, it's because this post does not have the frontpage tag: it is a personal blogpost.
...Personal Blogposts are posts that don't fit LessWrong's Frontpage Guidelines. They get less visibility by default. The frontpage guidelines are:
- Timelessness. Will people still care about this in 5 years?
- Avoid political topics. They're important to discuss sometimes, but we try to avoid it on
Mod here: most of the team were away over the weekend so we just didn't get around to processing this for personal vs frontpage yet. (All posts start as personal until approved to frontpage.) About to make a decision in this morning's moderation review session, as we do for all other new posts.
This isn't anywhere near the only example of this happening. It's just one of the few large examples where it's possible to find enough evidence that people won't just dismiss you as crazy.
I recall seeing most of this evidence before. It was dumbed on chan boards years ago. They even hacked the Wuhan lab, WHO, and Bill gates, and posted the files for everyone to see. I think some research data was included along with "evidence" of human engineering, but I would have to access illegal data and be competent enough to judge its validity in order to conf...
I appreciate you writing this post! I was curious about the evidence for lab leak, but was too lazy to investigate on my won.
You point out COVID-19 is the only sarbecovirus with furin cleavage site. But couldn't it have evolved by switching host from some other species? According to Nature, "viruses more often evolve by jumping from one host species to another than by remaining within a particular species."
So the general prevalence of furin cleavage sites seems relevant too. Did anyone look into what that is?
But gain of function is a new invention - it only really started in 2011 and funding was banned in 2014, then the moratorium was lifted in 2017. The 2011-2014 period had little or no coronavirus gain of function work as far as I am aware. So coronavirus gain of function from a lab could only have occurred after say 2010 and was most likely after 2017 when it had the combination of technology and funding.
Ralph Baric's lab was doing work that he thought would fall under the gain-of-function ban in 2014. He published the paper where Fauci said in front ...
... and we're supposed to believe that this is a coincidence? For the love of Bayes! How many times do you have to rerun history for a naturally occurring virus to randomly appear outside the lab that's studying it at the exact time they are studying it? I think it's at least 1000:1 against.
When I was thinking about this question earlier, I was imagining explaining my reasons to various different people (I think that imagining their response sometimes allows me to come up with counterarguments that otherwise I wouldn't think of). One of the things I w...
A bit off-topic, but one of my favourite positions is the "which cultural mores could allow this to happen?" angle. To get a feel for that you've got to think about what role vaccines play. They're part of health infrastructure and a matter of economic security, so enemy nations work hard to undermine these systems. An outbreak of measles and a load of blindness in the West would be great news for, say, Russia, so they spend to attack Western vaccination programmes. We do similar things like ship heroin from Afghanistan into Russia, while China floods West...
The LessWrong Review runs every year to select the posts that have most stood the test of time. This post is not yet eligible for review, but will be at the end of 2025. The top fifty or so posts are featured prominently on the site throughout the year.
Hopefully, the review is better than karma at judging enduring value. If we have accurate prediction markets on the review results, maybe we can have better incentives on LessWrong today. Will this post make the top fifty?
People often parse information through an epistemic consensus filter. They do not ask "is this true", they ask "will others be OK with me thinking this is true". This makes them very malleable to brute force manufactured consensus; if every screen they look at says the same thing they will adopt that position because their brain interprets it as everyone in the tribe believing it.
- Anon, 4Chan, slightly edited
Ordinary people who haven't spent years of their lives thinking about rationality and epistemology don't form beliefs by impartially tallying up evidence like a Bayesian reasoner. Whilst there is a lot of variation, my impression is that the majority of humans we share this Earth with use a completely different algorithm for vetting potential beliefs: they just believe some average of what everyone and everything around them believes, especially what they see on screens, newspapers and "respectable", "mainstream" websites.
This is a great algorithm from the point of view of the individual human. If the mainstream is wrong, well, "nobody got fired for buying IBM", as they say - you won't be personally singled out for being wrong if everyone else is also wrong. If the mainstream is right, you're also right. Win-win.
The problem with the "copy other people's beliefs" algorithm is that it is vulnerable to false information cascades. And when a small but powerful adversarial group controls the seed point for many people's beliefs (such as being able to control the scientific process to output chosen falsehoods), you can end up with an entire society believing an absurd falsehood that happens to be very convenient for that small, powerful adversarial subgroup.
DEFUSING your concerns
This is not a theoretical concern; I believe that brute-force manufactured consensus by the perpetrators is the cause of a lack of action to properly investigate and prosecute what I believe is the crime of the century: a group of scientists who I believe committed the equivalent of a modern holocaust (either deliberately or accidentally) are going to get away with it. For those who are not aware, the death toll of Covid-19 is estimated at between 19 million and 35 million.
Covid-19 likely came from a known lab (Wuhan Institute of Virology), was likely created by a known group of people (Peter Daszak & friends) acting against best practices and willing to lie about their safety standards to get the job done. In my opinion this amounts morally to a crime against humanity.
And the evidence keeps piling up - just this January, a freedom of information request surfaced a grant proposal dated 2018 with Daszak's name on it called Project DEFUSE, with essentially a recipe for making covid-19 at Wuhan Institute of Virology, including unique technical details like the Furin Cleavage Site and the BsmBI enzyme. Note the date - 3/27/2018.
Wait, there's more. Here, Peter Daszak tells other investigators that once they get funded by DARPA, they can do this work to make the novel coronavirus bond to the human ACE2 receptor in... Wuhan, China. Wow. Remember, this is in 2018! Now, DARPA refused to fund this proposal (perhaps they thought that this kind of research was too dangerous?) but this is hardly exculpatory. Daszak et al had the plan to make covid-19 in 2018, all they needed was funding, which they may simply have gotten from somewhere else.
So, Daszak & friends plan to create a novel coronavirus engineered to infect human cells with a Furin Cleavage Site in Wuhan, starting in mid-2018. Then in late 2019, a novel coronavirus that spreads rapidly through humans, that has a Furin Cleavage Site, appears in... Wuhan... thousands of miles away from the bat caves in Southern China where the closest natural variants live, and only a few miles from Wuhan Institute of Virology
... and we're supposed to believe that this is a coincidence? For the love of Bayes! How many times do you have to rerun history for a naturally occurring virus to randomly appear outside the lab that's studying it at the exact time they are studying it? I think it's at least 1000:1 against.
From Twitter:
There are >800 known sarbecoviruses. Only one--SARS-CoV-2--contains a furin cleavage site, as planned for insertion in EcoHealth DEFUSE proposal (P<0.002)
So not only is there a coincidence of timing and location, but also the virus has unique functional parts that occur in no other natural sarbecoviruses?
And they even got the WHO (World Health Organization) to allow them to investigate their own potential crime scene.
How are they getting away with this?
It seems that when Daszak, Fauci and others in the pro-gain-of-function virology community realized that covid-19 might be their own work escaping from the lab, they embarked upon a strategy of Brute Force Manufactured Consensus. They needed people to believe that covid-19 didn't come from their lab, so they just started manufacturing that consensus. And it worked!
Daszak and Fauci organized a letter in The Lancet which condemned any discussion of the possibility that covid-19 might be a lab leak as a "conspiracy theory". Daszak's name appears as one of the authors. That letter and the aura of officialness granted to it by The Lancet guided the mainstream media to denounce lab-origin theories as conspiracy theories, and that in turn caused most social media sites to ban any content discussing that, and even permanently delete people's social media profiles in some cases.
By 2022, things had calmed down a bit and people started to question whether there was a conflict of interests whereby the authors of the Lancet Letter which claimed that covid-19 Lab Leak theories were silly conspiracy theories might be part of an actual conspiracy to cover up the fact that covid-19 had escaped from their lab. Yikes!
But since then there have been further rounds of Brute Force Manufactured Consensus; for example a NYT article based on a paper by Worobey said that new evidence suggests that covid-19 started in Raccoon Dogs in a wildlife meat market. There are two problems with this: one, it's still an unlikely coincidence that a natural spillover event would just happen to occur right on the doorstep on WIV and right at the point in time when the Daszak/Ecohealth group was working on making a humanized coronavirus. Second, these papers have various fatal flaws, such as drawing heatmaps based on biased sampling - essentially they went and looked for covid-19 RNA around the raccoon dogs and they found it. But they didn't look as much elsewhere - obviously if you look more in one place, you'll find more in that place! But these downgrades to the credibility of the Worobey paper have not been widely reported on.
My personal breaking point on this is that yesterday, 2nd Feb 2024, The Global Catastrophic Risks institute released a report which found that in a survey of 162 "experts", about 80% of them thought that covid-19 had a natural origin.
However, about 80% of these "experts" said that they had not heard of the DEFUSE grant from 2018 that I just showed you above. You know, the one with Daszak's name on it, pictures of flappy bats and a step-by-step recipe for how to make covid-19.
So it seems that Brute Force Manufactured Consensus works on most (but not all) "experts" too. I mean, why wouldn't it? Some guy in 2024 working on his own little subfield of virology or epidemiology has no particular reason to deviate from the New York Times orthodoxy, and this is probably why only 22% of the experts said they had heard of DEFUSE but 33% said they had heard of Hanlen et al, 2022 - which is a fake study that doesn't exist and was inserted to check whether respondents were paying attention.
Now that public attention is off covid-19, the people responsible for it are mounting a perpetual delay-and-denial operation. UNC-Chapel Hill is in the process of hiding key documents which could contain further evidence about covid-19's origins right now. Scientists like Joseph Osmundson seem to think that killing 20 million people with an engineered virus is something to joke about and not take seriously, for example:
Small exchanges like this show the power of social consensus. If you can manufacture the right social consensus, control the key nodes in our social epistemology-plex, you can get away with just about anything and nobody will care, except a few very determined contrarians. But I will not go gentle into that good night.
EDIT, Afterthoughts:
Some people are claiming that there's a separate, honest case that covid-19 is probably a natural virus, so I thought I'd strengthen the Bayesian arguments against a natural origin a bit.
Here's an argument you could have made in early 2020 that covid-19 was not natural (and I did, on Metaculus). Wuhan has a population of 10 million or so, which is about 0.7% of the population of China. It is nowhere near Yunnan. Wuhan is also special with respect to dangerous biological work though, with China's first BSL-4 lab.
See also this Nature article from 2017:
If we search Google Scholar for "Coronavirus China" from 2000 to 2019, the top result is the WIV group. Granted, publicity since then may have boosted the scholar rank for WIV results more than for other groups, and Scholar doesn't allow you to easily see what the results would have been in 2019. But if we add the term "bat" to the search, Daszak, Ecohealth or WIV are included in all 8 of the top 8 results, for example in highly cited pre-2019 papers going back as far as 2007. Then there's this paper by Daszak from 2013 on coronaviruses and the ACE2 receptor which has 413 citations from before the pandemic.
Also, if we search Google limiting results to before 2019, we get various articles on WIV, Ecohealth and Daszak. There are some other groups who work on this. But the Wuhan/Ecohealth group is the most prominent by a long shot.
What are the chances that the bat coronavirus which caused a once in a century pandemic managed to navigate its way all the way from a Yunnan cave and home in on the city with the lab having the top Google hits for "Coronavirus China" and also the location of China's first BSL-4 lab? Well, that would be approximately 1 in 200, since that is the fraction of China's population in Wuhan.
We must also account for the timing here. Each year in the modern period from, say, 1970 until today has a decently large chance of human-animal transmission, perhaps with some bias towards the present due to more travel. But gain of function is a new invention - it only really started in 2011 and funding was banned in 2014, then the moratorium was lifted in 2017. The 2011-2014 period had little or no coronavirus gain of function work as far as I am aware. So coronavirus gain of function from a lab could only have occurred after say 2010 and was most likely after 2017 when it had the combination of technology and funding. This is a period of about 2 years out of the entire 1920-2020 hundred-year window. Now, we could probably discount that hundred year window down to say an equivalent of 40 years as people have become more mobile and more numerous in China over the past 100 years, on average. But that is still something like a 1 in 20 chance that the worst coronavirus pandemic of the past hundred years happened in the exact 2-year window when gain of function research was happening most aggressively, and that is independent from the location coincidence.
For a natural coronavirus century-scale pandemic spillover event to start in the specific location of the first BSL-4 lab and top Google hits for "coronavirus China", and to hit in the 2-year window of gain of function research after the funding moratorium is something like a 1 in 4000 chance; I can see this being knocked down a bit - maybe 1 in 1000 or even 1 in 500, depending on more complicated details of how natural spillovers would actually distribute in space and time. But not lower than that I think.
Another way to look at this is if gain-of-function research is safe and WIV is safe, then we'd typically expect the once-in-a-century pandemic to happen a long time before or a long time after gain-of-function research gets going, and quite a long way away from the biggest lab that does it. Perhaps it would have happened in say Xiamen in 2038.
These arguments are fairly robust to details about specific minor pieces of evidence or analyses. Whatever happens with all the minor arguments about enzymes and raccoon dogs and geospatial clustering, you still have to explain how the virus found its way to the place that got the first BSL-4 lab and the top Google hits for "Coronavirus China", and did so in slightly less than 2 years after the lifting of the moratorium on gain-of-function research. And I don't see how you can explain that other than that covid-19 escaped from WIV or a related facility in Wuhan.
Some of the more involved arguments about enzymes and stuff are pretty neat. But they are more involved, there are more places to go wrong or make a false assumption, and more places for an adversary to mess with the evidence.
One final way to look at this is imagine a time traveler appears to you in the 2000s and tells you that a massive global pandemic caused by a bat coronavirus happens at some point before 2020. If that pandemic is a natural spillover you shouldn't be able to use Google results from 2019 and Google Scholar results from 2019 to predict where and when it will occur by googling the type of virus and the host.
EDIT, AGAIN: I found one final thing in a twitter thread which is particularly damning - this Nature article from 2015: